The San Francisco 49ers had their highest spread differential in a game versus the Buccaneers on October 9, 2011, with a +42-spreads differential.
| TEAM | DATE | TM | OPP | RESULT | SPREAD | ATS DIFF | O/U | O/U DIFF | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | 49ers | 10/9/2011 | -150 | vs | +130 | W 48-3 | -3 | +42 (Y) | 41.5 | +9.5 (O) | 6 | 28 | 418 | 272 | 28.6 | 100.0 | ||
| 2 | | 49ers | 12/27/1987 | vs | W 48-0 | -9.5 | +38.5 (Y) | 41 | +7 (O) | 7 | 23 | 427 | 145 | ||||||
| 3 | | 49ers | 12/14/1987 | vs | W 41-0 | -5 | +36 (Y) | 45 | -4 (U) | 5 | 20 | 331 | 263 | ||||||
| 4 | | 49ers | 10/11/1981 | vs | W 45-14 | +5 | +36 (Y) | 45 | +14 (O) | 6 | 23 | 440 | 192 | ||||||
| 5 | | 49ers | 9/7/2003 | vs | W 49-7 | -6.5 | +35.5 (Y) | 40.5 | +15.5 (O) | 5 | 23 | 391 | 127 | 50.0 | 0.0 | ||||
| 6 | | 49ers | 1/6/2002 | @ | W 38-0 | -2.5 | +35.5 (Y) | 45.5 | -7.5 (U) | 5 | 22 | 407 | 126 | 35.7 | 50.0 | ||||
| 7 | | 49ers | 12/23/1991 | vs | W 52-14 | -3.5 | +34.5 (Y) | 37.5 | +28.5 (O) | 7 | 30 | 486 | 404 | 37.5 | |||||
| 8 | | 49ers | 10/27/2019 | -209 | vs | +172 | W 51-13 | -4 | +34 (Y) | 40.5 | +23.5 (O) | 7 | 24 | 388 | 230 | 50.0 | |||
| 9 | | 49ers | 10/16/1994 | @ | W 42-3 | -5 | +34 (Y) | 46.5 | -1.5 (U) | 6 | 16 | 281 | 254 | 46.2 | 60.0 | ||||
| 10 | | 49ers | 1/15/1994 | vs | W 44-3 | -7 | +34 (Y) | 41.5 | +5.5 (O) | 6 | 25 | 413 | 194 | 45.5 | 0.0 | ||||
| 11 | | 49ers | 9/8/1983 | @ | W 48-17 | +3 | +34 (Y) | 42 | +23 (O) | 6 | 21 | 413 | 340 | ||||||
| 12 | | 49ers | 1/28/1990 | @ | W 55-10 | -11.5 | +33.5 (Y) | 47 | +18 (O) | 8 | 28 | 461 | 167 | ||||||
| 13 | | 49ers | 11/1/2018 | +115 | vs | -125 | W 34-3 | +2 | +33 (Y) | 44 | -7 (U) | 4 | 18 | 405 | 242 | 41.7 | |||
| 14 | | 49ers | 10/7/2012 | -500 | vs | +400 | W 45-3 | -10 | +32 (Y) | 45.5 | +2.5 (O) | 6 | 29 | 621 | 204 | 63.6 | 100.0 | ||
| 15 | | 49ers | 11/12/1989 | vs | W 45-3 | -10 | +32 (Y) | 43 | +5 (O) | 6 | 30 | 515 | 192 | ||||||
| 16 | | 49ers | 9/12/2016 | +125 | vs | -145 | W 28-0 | +3 | +31 (Y) | 42.5 | -14.5 (U) | 4 | 28 | 320 | 185 | 47.1 | 50.0 | ||
| 17 | | 49ers | 11/12/1995 | @ | W 38-20 | +13 | +31 (Y) | 42 | +16 (O) | 5 | 21 | 386 | 296 | 60.0 | 0.0 | ||||
| 18 | | 49ers | 11/27/1988 | @ | W 48-10 | -7 | +31 (Y) | 38.5 | +19.5 (O) | 6 | 24 | 475 | 312 | ||||||
| 19 | | 49ers | 10/22/1995 | @ | W 44-10 | -3.5 | +30.5 (Y) | 40 | +14 (O) | 6 | 17 | 257 | 355 | 41.7 | |||||
| 20 | | 49ers | 10/25/2020 | +131 | @ | -155 | W 33-6 | +3 | +30 (Y) | 44.5 | -5.5 (U) | 4 | 26 | 467 | 241 | 55.6 | |||
| 21 | | 49ers | 9/30/2012 | -215 | @ | +180 | W 34-0 | -4 | +30 (Y) | 41 | -7 (U) | 4 | 26 | 381 | 145 | 33.3 | 100.0 | ||
| 22 | | 49ers | 9/14/1998 | @ | W 45-10 | -5 | +30 (Y) | 44 | +11 (O) | 6 | 28 | 504 | 322 | 58.3 | |||||
| 23 | | 49ers | 10/28/1984 | @ | W 33-0 | -3 | +30 (Y) | 45 | -12 (U) | 4 | 23 | 472 | 206 | ||||||
| 24 | | 49ers | 11/9/1992 | @ | W 41-3 | -9 | +29 (Y) | 45 | -1 (U) | 5 | 16 | 303 | 304 | 50.0 | |||||
| 25 | | 49ers | 10/18/1992 | vs | W 56-17 | -10 | +29 (Y) | 44.5 | +28.5 (O) | 8 | 29 | 590 | 297 | 60.0 | |||||
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WASResults may be incomplete. StatMuse has complete team, game-level data for spread differentials going back to the 1979 season.
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More 49ers Stats
Team Leaders 
PASS
2,167
Purdy
RUSH
1,202
McCaffrey
REC
924
McCaffrey
Team Rankings
PPG
25.7
10th
OPP PPG
21.8
13th
RUSH YDS/G
106.9
24th
PASS YDS/G
254.0
6th
NFL 2025 Leaders
NFL 2025 Rankings
NFL Fantasy 2025
NFL 2025 Betting
NFL 2025 Standings
| AFC East | W | L | T | PCT |
|---|---|---|---|---|
 Patriots - y | 14 | 3 | 0 | .824 |
 Bills - w | 12 | 5 | 0 | .706 |
 Dolphins - e | 7 | 10 | 0 | .412 |
 Jets - e | 3 | 14 | 0 | .176 |
| AFC North | W | L | T | PCT |
 Steelers - y | 10 | 7 | 0 | .588 |
 Ravens - e | 8 | 9 | 0 | .471 |
 Bengals - e | 6 | 11 | 0 | .353 |
 Browns - e | 5 | 12 | 0 | .294 |
| AFC South | W | L | T | PCT |
 Jaguars - y | 13 | 4 | 0 | .765 |
 Texans - w | 12 | 5 | 0 | .706 |
 Colts - e | 8 | 9 | 0 | .471 |
 Titans - e | 3 | 14 | 0 | .176 |
| AFC West | W | L | T | PCT |
 Broncos - z* | 14 | 3 | 0 | .824 |
 Chargers - w | 11 | 6 | 0 | .647 |
 Chiefs - e | 6 | 11 | 0 | .353 |
 Raiders - e | 3 | 14 | 0 | .176 |
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles - y | 11 | 6 | 0 | .647 |
 Cowboys - e | 7 | 9 | 1 | .441 |
 Commanders - e | 5 | 12 | 0 | .294 |
 Giants - e | 4 | 13 | 0 | .235 |
| NFC North | W | L | T | PCT |
 Bears - y | 11 | 6 | 0 | .647 |
 Packers - w | 9 | 7 | 1 | .559 |
 Vikings - e | 9 | 8 | 0 | .529 |
 Lions - e | 9 | 8 | 0 | .529 |
| NFC South | W | L | T | PCT |
 Panthers - y | 8 | 9 | 0 | .471 |
 Buccaneers - e | 8 | 9 | 0 | .471 |
 Falcons - e | 8 | 9 | 0 | .471 |
 Saints - e | 6 | 11 | 0 | .353 |
| NFC West | W | L | T | PCT |
 Seahawks - z* | 14 | 3 | 0 | .824 |
 Rams - w | 12 | 5 | 0 | .706 |
 49ers - w | 12 | 5 | 0 | .706 |
 Cardinals - e | 3 | 14 | 0 | .176 |