Shane Matthews has the highest completion percentage by a quarterback in a game with 20+ completions against the Patriots, at 81.5 percent on December 10, 2000.

highest completion percentage by quarterback with at least 20 completions in a game vs patriots
Interpreted as:
highest completion percentage by quarterback with at least 20 completions in a regular-season game vs patriots
12/10/2000Matthews12/4/2011Orlovsky10/25/2020Garoppolo9/7/2017Smith9/22/1974Snead9/7/1997Harbaugh11/13/2008Favre10/17/2010Flacco12/20/2020Tagovailoa9/29/2014Smith11/19/1995Harbaugh9/20/2015Taylor10/1/2017Newton9/15/1991Brister11/5/1989O'Brien11/22/2020Watson11/7/2005Manning12/28/2020Allen9/27/2020Carr9/20/2020Wilson9/23/2018Stafford10/6/2013Dalton10/4/2010Henne81.581.180.080.080.078.978.877.176.976.976.976.775.975.975.975.775.775.075.075.075.074.173.7
NAMEDATETMOPPPCTCMPATTYDSAVGTDTD%INTINT%SCKSCKYRATE
Shane MatthewsShane Matthews12/10/2000CHICHIvs. NE
vs.
81.522272398.927.400.012128.2
Dan OrlovskyDan Orlovsky12/4/2011INDIND@ NE
@
81.130373539.525.412.7215113.2
Jimmy GaroppoloJimmy Garoppolo10/25/2020SFSF@ NE
@
80.0202527711.100.028.01779.5
Alex SmithAlex Smith9/7/2017KCKC@ NE
@
80.0283536810.5411.400.0316148.6
Norm SneadNorm Snead9/22/1974NYGNYGvs. NE
vs.
80.028352727.825.712.9106.2
Jim HarbaughJim Harbaugh9/7/1997INDINDvs. NE
vs.
78.930382416.300.000.052793.1
Brett FavreBrett Favre11/13/2008NYJNYJ@ NE
@
78.826332587.826.100.0323119.4
Joe FlaccoJoe Flacco10/17/2010BALBAL@ NE
@
77.127352858.125.700.037119.3
Tua TagovailoaTua Tagovailoa12/20/2020MIAMIAvs. NE
vs.
76.920261455.600.013.821273.4
Alex SmithAlex Smith9/29/2014KCKCvs. NE
vs.
76.920262489.5311.500.0212144.4
Jim HarbaughJim Harbaugh11/19/1995INDIND@ NE
@
76.920262328.927.713.800113.0
Tyrod TaylorTyrod Taylor9/20/2015BUFBUFvs. NE
vs.
76.723302428.1310.0310.085393.3
Cam NewtonCam Newton10/1/2017CARCAR@ NE
@
75.9222931610.9310.313.4212130.8
Bubby BristerBubby Brister9/15/1991PITPITvs. NE
vs.
75.922292629.013.400.0115114.4
Ken O'BrienKen O'Brien11/5/1989NYJNYJ@ NE
@
75.9222938613.326.900.0212140.4
Deshaun WatsonDeshaun Watson11/22/2020HOUHOUvs. NE
vs.
75.728373449.325.400.000121.9
Peyton ManningPeyton Manning11/7/2005INDIND@ NE
@
75.728373218.738.112.700117.1
Josh AllenJosh Allen12/28/2020BUFBUF@ NE
@
75.027363208.9411.100.000138.7
Derek CarrDerek Carr9/27/2020LVLV@ NE
@
75.024322618.226.300.0212119.4
Russell WilsonRussell Wilson9/20/2020SEASEAvs. NE
vs.
75.0212828810.3517.913.6213132.1
Matthew StaffordMatthew Stafford9/23/2018DETDETvs. NE
vs.
75.027362627.325.612.817101.9
Andy DaltonAndy Dalton10/6/2013CINCINvs. NE
vs.
74.120272127.900.013.743381.1
Chad HenneChad Henne10/4/2010MIAMIAvs. NE
vs.
73.728383058.025.337.921281.6
Steve McNairSteve McNair9/20/1998TENTEN@ NE
@
73.728382025.312.625.32872.5
Ben RoethlisbergerBen Roethlisberger12/17/2017PITPITvs. NE
vs.
73.322302819.426.713.3211110.6
Results may be incomplete. StatMuse has complete game-level data for completion percentage and completions going back to the 1950 season.

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