Cecil Isbell had the most passing touchdowns in his last game, with 5 touchdowns against the Chicago Cardinals on November 1, 1942.

Interpreted as:

most passing touchdowns by a player last game

	NAME	TD	DATE	TM		OPP	CMP	ATT	PCT	YDS	AVG	INT	RTG	TD%	INT%	SCK	SCKY
1	Cecil Isbell C. Isbell	5	11/1/1942	GB	vs	CHC	10	21	47.6	333	15.9	1	113.6	23.8	4.8
2	Jordan Love J. Love	4	1/10/2026	GB	@	CHI	24	46	52.2	323	7.0	0	103.8	8.7	0.0	1	1
3	Mitchell Trubisky M. Trubisky	4	1/4/2026	BUF	vs	NYJ	22	29	75.9	259	8.9	0	142.1	13.8	0.0	0	0
4	Brian Sipe B. Sipe	4	12/18/1983	CLE	vs	PIT	14	22	63.6	199	9.0	0	132.4	18.2	0.0	1	3
5	Paul Governali P. Governali	4	12/7/1947	NYG	vs	WAS	12	20	60.0	255	12.8	0	143.8	20.0	0.0
6	Arnie Herber A. Herber	4	12/2/1945	NYG	vs	PHI	10	19	52.6	187	9.8	0	126.5	21.1	0.0
7	Roy McKay R. McKay	4	10/7/1945	GB	vs	DET	6	14	42.9	151	10.8	0	122.3	28.6	0.0
8	Frankie Sinkwich F. Sinkwich	4	11/19/1944	DET	vs	CHB	7	19	36.8	170	8.9	3	70.1	21.1	15.8
9	Matthew Stafford M. Stafford	3	1/25/2026	LAR	@	SEA	22	35	62.9	374	10.7	0	127.6	8.6	0.0	1	9
10	Josh Allen J. Allen	3	1/17/2026	BUF	@	DEN	25	39	64.1	283	7.3	2	90.0	7.7	5.1	3	17
11	Bo Nix B. Nix	3	1/17/2026	DEN	vs	BUF	26	46	56.5	279	6.1	1	87.1	6.5	2.2	0	0
12	Trevor Lawrence T. Lawrence	3	1/11/2026	JAX	vs	BUF	18	30	60.0	207	6.9	2	86.4	10.0	6.7	1	2
13	Joe Burrow J. Burrow	3	1/4/2026	CIN	vs	CLE	29	39	74.4	236	6.1	1	104.2	7.7	2.6	2	14
14	Lamar Jackson L. Jackson	3	1/4/2026	BAL	@	PIT	11	18	61.1	238	13.2	1	121.5	16.7	5.6	3	16
15	Kellen Moore K. Moore	3	1/3/2016	DAL	vs	WAS	33	48	68.8	435	9.1	2	100.6	6.3	4.2	4	23
16	Dick Jamieson D. Jamieson	3	10/23/1960	NYT	vs	HOU	11	16	68.8	245	15.3	0	151.0	18.8	0.0
17	Clyde LeForce C. LeForce	3	11/16/1947	DET	vs	WAS	15	24	62.5	317	13.2	2	111.1	12.5	8.3
18	Pat Coffee P. Coffee	3	12/5/1937	CHC	vs	CHB	15	33	45.5	306	9.3	2	83.6	9.1	6.1
19	Drake Maye D. Maye	2	2/8/2026	NE	vs	SEA	27	43	62.8	295	6.9	2	79.1	4.7	4.7	6	43
20	Caleb Williams C. Williams	2	1/18/2026	CHI	vs	LAR	23	42	54.8	257	6.1	3	59.3	4.8	7.1	0	0
21	Riley Leonard R. Leonard	2	1/4/2026	IND	@	HOU	21	34	61.8	270	7.9	1	94.0	5.9	2.9	1	8
22	Jacoby Brissett J. Brissett	2	1/4/2026	ARI	@	LAR	22	31	71.0	243	7.8	1	101.9	6.5	3.2	6	33
23	Jaxson Dart J. Dart	2	1/4/2026	NYG	vs	DAL	22	32	68.8	230	7.2	0	110.2	6.3	0.0	4	11
24	Tua Tagovailoa T. Tagovailoa	2	12/15/2025	MIA	@	PIT	22	28	78.6	253	9.0	1	113.2	7.1	3.6	4	31
25	Ryan Tannehill R. Tannehill	2	1/7/2024	TEN	vs	JAX	17	26	65.4	168	6.5	1	93.1	7.7	3.8	2	16

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Results may be incomplete. StatMuse has complete game-level data for passing touchdowns going back to the 1950 season.

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