45 players are tied for the most touchdown returns in a game, with 2 touchdown returns. The first three are Kenny Moore II on November 5, 2023, Nyheim Hines on January 8, 2023 and on December 22, 2019 and Mike Edwards on September 19, 2021.

Interpreted as:

most return touchdowns by a player in a regular-season game

	NAME	RET TD	DATE	TM		OPP	KR	KR YDS	KR AVG	KR TD	PR	PR YDS	PR AVG	PR TD
1	Kenny Moore II K. Moore II	2	11/5/2023	IND	@	CAR	0	0		0	0	0		0
2	Nyheim Hines N. Hines	2	1/8/2023	BUF	vs	NE	4	235	58.8	2	1	6	6.0	0
3	Mike Edwards M. Edwards	2	9/19/2021	TB	vs	ATL	0	0		0	0	0		0
4	Jeremy Chinn J. Chinn	2	11/29/2020	CAR	@	MIN	0	0		0	0	0		0
5	Nyheim Hines N. Hines	2	12/22/2019	IND	vs	CAR	0	0		0	3	195	65.0	2
6	Samson Ebukam S. Ebukam	2	11/19/2018	LAR	vs	KC	0	0		0	0	0		0
7	Eddie Jackson E. Jackson	2	10/22/2017	CHI	vs	CAR	0	0		0	0	0		0
8	Jeremy Ross J. Ross	2	12/8/2013	DET	@	PHI	4	172	43.0	1	2	71	35.5	1
9	Zach Brown Z. Brown	2	12/30/2012	TEN	vs	JAX	0	0		0	0	0		0
10	Darius Reynaud D. Reynaud	2	12/30/2012	TEN	vs	JAX	3	39	13.0	0	3	160	53.3	2
11	Janoris Jenkins J. Jenkins	2	11/25/2012	STL	@	ARI	0	0		0	0	0		0
12	Ted Ginn T. Ginn	2	9/11/2011	SF	vs	SEA	4	176	44.0	1	5	92	18.4	1
13	David Bowens D. Bowens	2	10/24/2010	CLE	@	NO	0	0		0	0	0		0
14	Leon Washington L. Washington	2	9/26/2010	SEA	vs	SD	4	253	63.3	2	0	0		0
15	Derrick Johnson D. Johnson	2	1/3/2010	KC	@	DEN	0	0		0	0	0		0
16	Josh Cribbs J. Cribbs	2	12/20/2009	CLE	@	KC	6	269	44.8	2	4	36	9.0	0
17	Ted Ginn T. Ginn	2	11/1/2009	MIA	@	NYJ	6	299	49.8	2	0	0		0
18	Eddie Royal E. Royal	2	10/19/2009	DEN	@	SD	5	158	31.6	1	3	77	25.7	1
19	Reggie Bush R. Bush	2	10/6/2008	NO	vs	MIN	0	0		0	5	176	35.2	2
20	Andre Davis A. Davis	2	12/30/2007	HOU	vs	JAX	5	234	46.8	2	0	0		0
21	Will Blackmon W. Blackmon	2	12/9/2007	GB	vs	OAK	0	0		0	3	63	21.0	1
22	Devin Hester D. Hester	2	11/25/2007	CHI	vs	DEN	5	151	30.2	1	5	81	16.2	1
23	Antrel Rolle A. Rolle	2	11/18/2007	ARI	@	CIN	0	0		0	0	0		0
24	Darren Sproles D. Sproles	2	11/11/2007	SD	vs	IND	3	125	41.7	1	1	45	45.0	1
25	Antonio Cromartie A. Cromartie	2	10/28/2007	SD	vs	HOU	0	0		0	0	0		0

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Results may be incomplete. StatMuse has complete game-level data for touchdown returns going back to the 1950 season.

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45 players are tied for the most touchdown returns in a game, with 2 touchdown returns. The first three are Kenny Moore II on November 5, 2023, Nyheim Hines on January 8, 2023 and on December 22, 2019 and Mike Edwards on September 19, 2021.

Interpreted as:

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