O.J. Simpson has the most rushing yards in a Week-1 game, with 250 yards against the Patriots on September 16, 1973.
Interpreted as:
most rushing yards by a player in a week 1 game| NAME | RUSH YDS | DATE | TM | OPP | ATT | YPC | RUSH TD | REC YDS | REC | TRG | AVG | REC TD | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | O.J. Simpson | 250 | 9/16/1973 | @ | 29 | 8.6 | 2 | 0 | 0 | 0 | ||||
| 2 |  | A. Foster | 231 | 9/12/2010 | vs | 33 | 7.0 | 3 | 7 | 1 | 1 | 7.0 | 0 | ||
| 3 | | M. Turner | 220 | 9/7/2008 | vs | 22 | 10.0 | 2 | 6 | 1 | 1 | 6.0 | 0 | ||
| 4 | | E. George | 216 | 8/31/1997 | vs | 35 | 6.2 | 1 | 0 | 0 | 0 | ||||
| 5 | | G. Rogers | 206 | 9/4/1983 | vs | 24 | 8.6 | 2 | 0 | 0 | 0 | ||||
| 6 | | G. Riggs | 202 | 9/2/1984 | @ | 35 | 5.8 | 2 | 0 | 0 | 0 | ||||
| 7 | | D. Staley | 201 | 9/3/2000 | @ | 26 | 7.7 | 1 | 61 | 4 | 7 | 15.3 | 0 | ||
| 8 | | N. Bulaich | 198 | 9/19/1971 | vs | 22 | 9.0 | 1 | 0 | 0 | 0 | ||||
| 9 |  | C. Martin | 196 | 9/12/2004 | vs | 29 | 6.8 | 1 | 7 | 3 | 3 | 2.3 | 1 | ||
| 10 | | A. Ameche | 194 | 9/25/1955 | vs | 21 | 9.2 | 1 | |||||||
| 11 |  | E. Dickerson | 193 | 9/7/1986 | @ | 38 | 5.1 | 2 | 0 | 0 | 0 | ||||
| 12 | | O. Anderson | 193 | 9/2/1979 | vs | 21 | 9.2 | 1 | 0 | 0 | 0 | ||||
| 13 | | G. Hearst | 187 | 9/6/1998 | vs | 20 | 9.4 | 2 | 38 | 2 | 19.0 | 0 | |||
| 14 |  | L. McCoy | 184 | 9/9/2013 | @ | 31 | 5.9 | 1 | 5 | 1 | 1 | 5.0 | 0 | ||
| 15 | | W. Galimore | 181 | 9/16/1962 | @ | 22 | 8.2 | 2 | 7 | 1 | 7.0 | 0 | |||
| 16 |  | A. Peterson | 180 | 9/13/2009 | @ | 25 | 7.2 | 3 | 18 | 1 | 1 | 18.0 | 0 | ||
| 17 | | C. Brown | 175 | 9/9/2007 | @ | 19 | 9.2 | 0 | 3 | 1 | 1 | 3.0 | 0 | ||
| 18 |  | M. Mack | 174 | 9/8/2019 | @ | 25 | 7.0 | 1 | 0 | 0 | 0 | 0 | |||
| 19 | | J. Jones | 174 | 9/7/1986 | @ | 36 | 4.8 | 1 | 0 | 0 | 0 | ||||
| 20 | | O.J. Simpson | 173 | 9/21/1975 | vs | 32 | 5.4 | 2 | 5 | 1 | 5.0 | 0 | |||
| 21 |  | E. Smith | 171 | 9/4/1994 | @ | 31 | 5.5 | 1 | 3 | 3 | 1.0 | 0 | |||
| 22 |  | J. Brown | 171 | 9/28/1958 | @ | 24 | 7.1 | 2 | |||||||
| 23 |  | D. Henry | 169 | 9/7/2025 | @ | 18 | 9.4 | 2 | 13 | 1 | 1 | 13.0 | 0 | ||
| 24 | | C.J. Spiller | 169 | 9/9/2012 | @ | 14 | 12.1 | 1 | 25 | 2 | 3 | 12.5 | 0 | ||
| 25 | | R. Smith | 169 | 8/31/1997 | @ | 16 | 10.6 | 1 | 5 | 1 | 5.0 | 0 | |||
TEN
STL
BAL
NYJ
CHB
RAM
WASResults may be incomplete. StatMuse has complete game-level data for rushing yards going back to the 1960 season.
More Bills Stats
Team Leaders 
PASS
3,668
Allen
RUSH
1,621
Cook
REC
719
Shakir
Team Rankings
PPG
28.3
4th
OPP PPG
21.5
12th
RUSH YDS/G
159.6
1st
PASS YDS/G
234.2
13th
NFL 2025 Leaders
NFL 2025 Rankings
NFL Fantasy 2025
NFL 2025 Betting
NFL 2025 Standings
| AFC East | W | L | T | PCT |
|---|---|---|---|---|
 Patriots - y | 14 | 3 | 0 | .824 |
 Bills - w | 12 | 5 | 0 | .706 |
 Dolphins - e | 7 | 10 | 0 | .412 |
 Jets - e | 3 | 14 | 0 | .176 |
| AFC North | W | L | T | PCT |
 Steelers - y | 10 | 7 | 0 | .588 |
 Ravens - e | 8 | 9 | 0 | .471 |
 Bengals - e | 6 | 11 | 0 | .353 |
 Browns - e | 5 | 12 | 0 | .294 |
| AFC South | W | L | T | PCT |
 Jaguars - y | 13 | 4 | 0 | .765 |
 Texans - w | 12 | 5 | 0 | .706 |
 Colts - e | 8 | 9 | 0 | .471 |
 Titans - e | 3 | 14 | 0 | .176 |
| AFC West | W | L | T | PCT |
 Broncos - z* | 14 | 3 | 0 | .824 |
 Chargers - w | 11 | 6 | 0 | .647 |
 Chiefs - e | 6 | 11 | 0 | .353 |
 Raiders - e | 3 | 14 | 0 | .176 |
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles - y | 11 | 6 | 0 | .647 |
 Cowboys - e | 7 | 9 | 1 | .441 |
 Commanders - e | 5 | 12 | 0 | .294 |
 Giants - e | 4 | 13 | 0 | .235 |
| NFC North | W | L | T | PCT |
 Bears - y | 11 | 6 | 0 | .647 |
 Packers - w | 9 | 7 | 1 | .559 |
 Vikings - e | 9 | 8 | 0 | .529 |
 Lions - e | 9 | 8 | 0 | .529 |
| NFC South | W | L | T | PCT |
 Panthers - y | 8 | 9 | 0 | .471 |
 Buccaneers - e | 8 | 9 | 0 | .471 |
 Falcons - e | 8 | 9 | 0 | .471 |
 Saints - e | 6 | 11 | 0 | .353 |
| NFC West | W | L | T | PCT |
 Seahawks - z* | 14 | 3 | 0 | .824 |
 Rams - w | 12 | 5 | 0 | .706 |
 49ers - w | 12 | 5 | 0 | .706 |
 Cardinals - e | 3 | 14 | 0 | .176 |
