The Buffalo Bills had their most all-purpose yards in a game in 2021 against the Jets on November 14, 2021, with 489 yards.
| TEAM | YDS | DATE | TM | OPP | RESULT | TD | PASS YDS | SCKY | PASS TD | RUSH YDS | RUSH TD | RET YDS | RET TD | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | Bills | 489 | 11/14/2021 | @ | W 45-17 | 6 | 366 | 16 | 2 | 139 | 4 | 40 | 0 | ||
| 2 | | Bills | 481 | 9/26/2021 | vs | W 43-21 | 5 | 359 | 0 | 4 | 122 | 1 | 26 | 0 | ||
| 3 | | Bills | 466 | 12/12/2021 | @ | L 27-33 | 3 | 308 | 15 | 2 | 173 | 1 | 38 | 0 | ||
| 4 | | Bills | 450 | 10/3/2021 | vs | W 40-0 | 4 | 256 | 5 | 2 | 199 | 2 | 44 | 0 | ||
| 5 | | Bills | 436 | 10/10/2021 | @ | W 38-20 | 5 | 315 | 0 | 3 | 121 | 1 | 11 | 1 | ||
| 6 | | Bills | 428 | 12/26/2021 | @ | W 33-21 | 4 | 314 | 0 | 3 | 114 | 1 | 83 | 0 | ||
| 7 | | Bills | 424 | 1/9/2022 | vs | W 27-10 | 3 | 254 | 0 | 2 | 170 | 1 | 28 | 0 | ||
| 8 | | Bills | 417 | 10/18/2021 | @ | L 31-34 | 3 | 353 | 18 | 3 | 82 | 0 | 83 | 0 | ||
| 9 | | Bills | 371 | 9/12/2021 | vs | L 16-23 | 1 | 270 | 16 | 1 | 117 | 0 | 144 | 0 | ||
| 10 | | Bills | 361 | 11/25/2021 | @ | W 31-6 | 4 | 260 | 12 | 4 | 113 | 0 | 84 | 0 | ||
| 11 | | Bills | 351 | 1/2/2022 | vs | W 29-15 | 4 | 120 | 2 | 0 | 233 | 4 | 83 | 0 | ||
| 12 | | Bills | 351 | 10/31/2021 | vs | W 26-11 | 3 | 249 | 0 | 2 | 102 | 1 | 62 | 0 | ||
| 13 | | Bills | 314 | 9/19/2021 | @ | W 35-0 | 5 | 179 | 8 | 2 | 143 | 3 | 33 | 0 | ||
| 14 | | Bills | 312 | 12/19/2021 | vs | W 31-14 | 4 | 210 | 17 | 3 | 119 | 1 | 80 | 0 | ||
| 15 | | Bills | 311 | 11/21/2021 | vs | L 15-41 | 2 | 228 | 8 | 2 | 91 | 0 | 138 | 0 | ||
| 16 | | Bills | 301 | 11/7/2021 | @ | L 6-9 | 0 | 264 | 35 | 0 | 72 | 0 | 129 | 0 | ||
| 17 | | Bills | 230 | 12/6/2021 | vs | L 10-14 | 1 | 145 | 14 | 1 | 99 | 0 | 35 | 0 |
NYJ
WASMore Bills Stats
Team Leaders 
PASS
3,668
Allen
RUSH
1,621
Cook
REC
719
Shakir
Team Rankings
PPG
28.3
4th
OPP PPG
21.5
12th
RUSH YDS/G
159.6
1st
PASS YDS/G
234.2
13th
NFL 2025 Leaders
NFL 2025 Rankings
NFL Fantasy 2025
NFL 2025 Betting
NFL 2025 Standings
| AFC East | W | L | T | PCT |
|---|---|---|---|---|
 Patriots - y | 14 | 3 | 0 | .824 |
 Bills - w | 12 | 5 | 0 | .706 |
 Dolphins - e | 7 | 10 | 0 | .412 |
 Jets - e | 3 | 14 | 0 | .176 |
| AFC North | W | L | T | PCT |
 Steelers - y | 10 | 7 | 0 | .588 |
 Ravens - e | 8 | 9 | 0 | .471 |
 Bengals - e | 6 | 11 | 0 | .353 |
 Browns - e | 5 | 12 | 0 | .294 |
| AFC South | W | L | T | PCT |
 Jaguars - y | 13 | 4 | 0 | .765 |
 Texans - w | 12 | 5 | 0 | .706 |
 Colts - e | 8 | 9 | 0 | .471 |
 Titans - e | 3 | 14 | 0 | .176 |
| AFC West | W | L | T | PCT |
 Broncos - z* | 14 | 3 | 0 | .824 |
 Chargers - w | 11 | 6 | 0 | .647 |
 Chiefs - e | 6 | 11 | 0 | .353 |
 Raiders - e | 3 | 14 | 0 | .176 |
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles - y | 11 | 6 | 0 | .647 |
 Cowboys - e | 7 | 9 | 1 | .441 |
 Commanders - e | 5 | 12 | 0 | .294 |
 Giants - e | 4 | 13 | 0 | .235 |
| NFC North | W | L | T | PCT |
 Bears - y | 11 | 6 | 0 | .647 |
 Packers - w | 9 | 7 | 1 | .559 |
 Vikings - e | 9 | 8 | 0 | .529 |
 Lions - e | 9 | 8 | 0 | .529 |
| NFC South | W | L | T | PCT |
 Panthers - y | 8 | 9 | 0 | .471 |
 Buccaneers - e | 8 | 9 | 0 | .471 |
 Falcons - e | 8 | 9 | 0 | .471 |
 Saints - e | 6 | 11 | 0 | .353 |
| NFC West | W | L | T | PCT |
 Seahawks - z* | 14 | 3 | 0 | .824 |
 Rams - w | 12 | 5 | 0 | .706 |
 49ers - w | 12 | 5 | 0 | .706 |
 Cardinals - e | 3 | 14 | 0 | .176 |
