Derrick Henry had his most rushing yards in a game against the Texans on January 3, 2021, with 250 yards.
Interpreted as:
most rushing yards in a regular-season game Derrick Henry| NAME | RUSH YDS | DATE | TM | OPP | ATT | YPC | RUSH TD | REC YDS | REC | TRG | AVG | REC TD | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | D. Henry | 250 | 1/3/2021 |  TEN | @ |  HOU | 34 | 7.4 | 2 | 0 | 0 | 0 | 0 | |
| 2 | | D. Henry | 238 | 12/6/2018 | TEN | vs |  JAX | 17 | 14.0 | 4 | 0 | 0 | 0 | 0 | |
| 3 | | D. Henry | 219 | 10/30/2022 | TEN | @ | HOU | 32 | 6.8 | 2 | 9 | 1 | 1 | 9.0 | 0 |
| 4 | | D. Henry | 215 | 12/13/2020 | TEN | @ | JAX | 26 | 8.3 | 2 | 7 | 2 | 2 | 3.5 | 0 |
| 5 | | D. Henry | 212 | 10/18/2020 | TEN | vs | HOU | 22 | 9.6 | 2 | 52 | 2 | 5 | 26.0 | 0 |
| 6 | | D. Henry | 211 | 12/29/2019 | TEN | @ | HOU | 32 | 6.6 | 3 | 0 | 0 | 0 | 0 | |
| 7 |  | D. Henry | 199 | 9/29/2024 |  BAL | vs |  BUF | 24 | 8.3 | 1 | 10 | 3 | 3 | 3.3 | 1 |
| 8 | | D. Henry | 188 | 11/10/2019 | TEN | vs |  KC | 23 | 8.2 | 2 | 3 | 2 | 2 | 1.5 | 0 |
| 9 | | D. Henry | 182 | 9/19/2021 | TEN | @ |  SEA | 35 | 5.2 | 3 | 55 | 6 | 6 | 9.2 | 0 |
| 10 | | D. Henry | 178 | 11/29/2020 | TEN | @ |  IND | 27 | 6.6 | 3 | 7 | 2 | 4 | 3.5 | 0 |
| 11 | | D. Henry | 170 | 12/16/2018 | TEN | @ |  NYG | 33 | 5.2 | 2 | 0 | 1 | 1 | 0.0 | 0 |
| 12 | | D. Henry | 169 | 9/7/2025 | BAL | @ | BUF | 18 | 9.4 | 2 | 13 | 1 | 1 | 13.0 | 0 |
| 13 | | D. Henry | 169 | 10/21/2024 | BAL | @ |  TB | 15 | 11.3 | 0 | 13 | 1 | 1 | 13.0 | 1 |
| 14 | | D. Henry | 162 | 12/21/2024 | BAL | vs |  PIT | 24 | 6.8 | 0 | 27 | 2 | 2 | 13.5 | 0 |
| 15 | | D. Henry | 159 | 11/24/2019 | TEN | vs | JAX | 19 | 8.4 | 2 | 16 | 1 | 1 | 16.0 | 0 |
| 16 | | D. Henry | 157 | 10/3/2021 | TEN | @ |  NYJ | 33 | 4.8 | 1 | 20 | 2 | 2 | 10.0 | 0 |
| 17 | | D. Henry | 153 | 1/7/2024 | TEN | vs | JAX | 19 | 8.1 | 1 | 0 | 0 | 0 | 0 | |
| 18 | | D. Henry | 151 | 9/22/2024 | BAL | @ |  DAL | 25 | 6.0 | 2 | 23 | 1 | 1 | 23.0 | 0 |
| 19 | | D. Henry | 149 | 12/1/2019 | TEN | @ | IND | 26 | 5.7 | 1 | 17 | 3 | 3 | 5.7 | 0 |
| 20 | | D. Henry | 147 | 12/25/2024 | BAL | @ | HOU | 27 | 5.4 | 1 | 18 | 2 | 2 | 9.0 | 0 |
| 21 | | D. Henry | 147 | 12/20/2020 | TEN | vs |  DET | 24 | 6.1 | 1 | 5 | 2 | 2 | 2.5 | 0 |
| 22 | | D. Henry | 143 | 10/18/2021 | TEN | vs | BUF | 20 | 7.2 | 3 | 13 | 2 | 3 | 6.5 | 0 |
| 23 | | D. Henry | 140 | 11/25/2024 | BAL | @ |  LAC | 24 | 5.8 | 0 | 0 | 0 | 0 | 0 | |
| 24 | | D. Henry | 138 | 1/4/2025 | BAL | vs |  CLE | 20 | 6.9 | 2 | 23 | 2 | 3 | 11.5 | 0 |
| 25 | | D. Henry | 133 | 11/22/2020 | TEN | @ | BAL | 28 | 4.8 | 1 | -1 | 1 | 2 | -1.0 | 0 |
Results may be incomplete. StatMuse has complete game-level data for rushing yards going back to the 1960 season.
More Titans Stats
Team Rankings
PPG
17.0
28th
OPP PPG
31.3
30th
RUSH YDS/G
88.7
28th
PASS YDS/G
168.7
29th
ARI 
LV 
NE 
NFL 2025 Leaders
NFL 2025 Rankings
NFL Fantasy 2025
NFL 2025 Betting
NFL 2025 Division Standings
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles | 3 | 0 | 0 | 1.000 |
 Commanders | 2 | 1 | 0 | .667 |
| NFC North | W | L | T | PCT |
 Packers | 2 | 1 | 0 | .667 |
 Vikings | 2 | 1 | 0 | .667 |
| NFC South | W | L | T | PCT |
| Buccaneers | 3 | 0 | 0 | 1.000 |
 Panthers | 1 | 2 | 0 | .333 |
| NFC West | W | L | T | PCT |
 49ers | 3 | 0 | 0 | 1.000 |
 Rams | 2 | 1 | 0 | .667 |
Bengals 
NYJ 
ATL 
NO 
