The San Francisco 49ers have a 22-20 record against the AFC in the regular-season and playoffs since 2017.
| TEAM | DATE | REC | TM | OPP | RESULT | W% | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | 49ers | 10/8/2017 | 0-1 |  SF | @ |  IND | L 23-26 | .000 | 2 | 23 | 402 | 447 | 28.6 | 100.0 |
| 2 | | 49ers | 12/10/2017 | 1-0 | SF | @ |  HOU | W 26-16 | 1.000 | 2 | 20 | 416 | 311 | 18.2 | |
| 3 | | 49ers | 12/17/2017 | 1-0 | SF | vs |  TEN | W 25-23 | 1.000 | 1 | 23 | 414 | 328 | 50.0 | |
| 4 | | 49ers | 12/24/2017 | 1-0 | SF | vs |  JAX | W 44-33 | 1.000 | 6 | 26 | 369 | 472 | 66.7 | |
| 5 | | 49ers | 9/23/2018 | 0-1 | SF | @ |  KC | L 27-38 | .000 | 3 | 26 | 406 | 384 | 22.2 | 100.0 |
| 6 | | 49ers | 9/30/2018 | 0-1 | SF | @ |  LAC | L 27-29 | .000 | 3 | 22 | 364 | 368 | 41.7 | |
| 7 | | 49ers | 11/1/2018 | 1-0 | SF | vs |  OAK | W 34-3 | 1.000 | 4 | 18 | 405 | 242 | 41.7 | |
| 8 | | 49ers | 12/9/2018 | 1-0 | SF | vs |  DEN | W 20-14 | 1.000 | 2 | 24 | 389 | 274 | 30.8 | 0.0 |
| 9 | | 49ers | 9/15/2019 | 1-0 | SF | @ |  CIN | W 41-17 | 1.000 | 5 | 27 | 571 | 316 | 55.6 | |
| 10 | | 49ers | 9/22/2019 | 1-0 | SF | vs |  PIT | W 24-20 | 1.000 | 3 | 26 | 436 | 239 | 54.5 | |
| 11 | | 49ers | 10/7/2019 | 1-0 | SF | vs |  CLE | W 31-3 | 1.000 | 4 | 22 | 446 | 180 | 37.5 | 100.0 |
| 12 | | 49ers | 12/1/2019 | 0-1 | SF | @ |  BAL | L 17-20 | .000 | 2 | 15 | 331 | 283 | 33.3 | 50.0 |
| 13 | | 49ers | 2/2/2020 | 0-1 | SF | @ | KC | L 20-31 | .000 | 2 | 21 | 351 | 397 | 37.5 | 0.0 |
| 14 | | 49ers | 9/20/2020 | 1-0 | SF | @ |  NYJ | W 31-13 | 1.000 | 4 | 17 | 359 | 277 | 53.8 | |
| 15 | | 49ers | 10/11/2020 | 0-1 | SF | vs |  MIA | L 17-43 | .000 | 2 | 19 | 259 | 436 | 20.0 | 0.0 |
| 16 | | 49ers | 10/25/2020 | 1-0 | SF | @ |  NE | W 33-6 | 1.000 | 4 | 26 | 467 | 241 | 55.6 | |
| 17 | | 49ers | 12/7/2020 | 0-1 | SF | vs |  BUF | L 24-34 | .000 | 3 | 24 | 402 | 449 | 54.5 | 0.0 |
| 18 | | 49ers | 10/24/2021 | 0-1 | SF | vs | IND | L 18-30 | .000 | 2 | 13 | 280 | 295 | 9.1 | |
| 19 | | 49ers | 11/21/2021 | 1-0 | SF | @ | JAX | W 30-10 | 1.000 | 3 | 25 | 333 | 200 | 50.0 | 100.0 |
| 20 | | 49ers | 12/12/2021 | 1-0 | SF | @ | CIN | W 26-23 | 1.000 | 3 | 21 | 355 | 397 | 33.3 | |
| 21 | | 49ers | 12/23/2021 | 0-1 | SF | @ | TEN | L 17-20 | .000 | 2 | 22 | 389 | 278 | 37.5 | 50.0 |
| 22 | | 49ers | 1/2/2022 | 1-0 | SF | vs | HOU | W 23-7 | 1.000 | 2 | 19 | 416 | 222 | 38.5 | 0.0 |
| 23 | | 49ers | 9/25/2022 | 0-1 | SF | @ | DEN | L 10-11 | .000 | 1 | 13 | 267 | 261 | 10.0 | |
| 24 | | 49ers | 10/23/2022 | 0-1 | SF | vs | KC | L 23-44 | .000 | 2 | 25 | 444 | 529 | 57.1 | |
| 25 | | 49ers | 11/13/2022 | 1-0 | SF | vs | LAC | W 22-16 | 1.000 | 2 | 22 | 387 | 238 | 52.9 | 100.0 |
| Average | .524 | 2.7 | 21.3 | 376.8 | 328.3 | 41.8 | 2.2 | ||||||||
| Total | 22-20 | .524 | 112 | 893 | 15,826 | 13,787 | 41.8 | 51.5 | |||||||
More 49ers Stats
Team Leaders 
PASS
2,151
Jones
RUSH
922
McCaffrey
REC
820
McCaffrey
Team Rankings
PPG
24.6
11th
OPP PPG
20.9
11th
RUSH YDS/G
101.4
25th
PASS YDS/G
256.6
6th
Rams
Seahawks
Cardinals
CHI
Eagles
Cowboys
Packers
Buccaneers
Panthers
NO
WAS
