49 players are tied for the most safeties in a loss, with 1 safety. The first three are Daron Payne on October 19 and on September 25, 2022, Kaevon Merriweather on September 28 and Kamari Lassiter on December 25, 2024.

Interpreted as:

player most safety in a regular-season game in losses

	NAME	SFTY	L	DATE	TM		OPP	TKL	AST	COMB	SCK	SCKY	INT	INT YDS	INT TD	FF	FR	FR TD
1	Daron Payne D. Payne	1	1	10/19/2025	WAS	@	DAL	1	4	5	0.0	0	0	0	0	0	0	0
2	Kaevon Merriweather K. Merriweather	1	1	9/28/2025	TB	vs	PHI	1	1	2	0.0	0	0	0	0	0	0	0
3	Kamari Lassiter K. Lassiter	1	1	12/25/2024	HOU	vs	BAL	3	3	6	0.0	0	0	0	0	0	0	0
4	Sam Hubbard S. Hubbard	1	1	10/6/2024	CIN	vs	BAL	7	2	9	1.0	3	0	0	0	0	0	0
5	Dre'Mont Jones D. Jones	1	1	9/30/2024	SEA	@	DET	1	1	2	1.0	4	0	0	0	0	0	0
6	Zach Allen Z. Allen	1	1	9/8/2024	DEN	@	SEA	1	1	2	0.0	0	0	0	0	0	0	0
7	Ameer Speed A. Speed	1	1	1/6/2024	IND	vs	HOU	1	0	1	0.0	0	0	0	0	0	0	0
8	Ashtyn Davis A. Davis	1	1	12/3/2023	NYJ	vs	ATL	2	0	2	0.0	0	0	0	0	0	0	0
9	Calais Campbell C. Campbell	1	1	11/5/2023	ATL	vs	MIN	4	0	4	1.0	5	0	0	0	0	0	0
10	Jermaine Johnson J. Johnson	1	1	12/11/2022	NYJ	@	BUF	0	0	0	0.0	0	0	0	0	0	0	0
11	Roy Lopez R. Lopez	1	1	12/4/2022	HOU	vs	CLE	5	0	5	0.0	0	0	0	0	0	0	0
12	Sebastian Joseph-Day S. Joseph-Day	1	1	10/23/2022	LAC	vs	SEA	2	2	4	0.0	0	0	0	0	0	0	0
13	Josiah Deguara J. Deguara	1	1	10/9/2022	GB	vs	NYG	1	0	1	0.0	0	0	0	0	0	0	0
14	Daron Payne D. Payne	1	1	9/25/2022	WAS	vs	PHI	1	2	3	0.0	0	0	0	0	0	0	0
15	Dee Alford D. Alford	1	1	9/18/2022	ATL	@	LAR	2	0	2	0.0	0	0	0	0	0	0	0
16	Jacob Martin J. Martin	1	1	10/24/2021	HOU	@	ARI	2	2	4	0.0	0	0	0	0	0	0	0
17	Romeo Okwara R. Okwara	1	1	12/20/2020	DET	@	TEN	4	0	4	1.0	5	0	0	0	0	0	0
18	Ryan Neal R. Neal	1	1	12/6/2020	SEA	vs	NYG	0	0	0	0.0	0	0	0	0	0	0	0
19	Frankie Luvu F. Luvu	1	1	11/22/2020	NYJ	@	LAC	2	0	2	0.0	0	0	0	0	0	0	0
20	Tremaine Edmunds T. Edmunds	1	1	11/10/2019	BUF	@	CLE	2	2	4	1.0	8	0	0	0	0	0	0
21	Aaron Donald A. Donald	1	1	11/10/2019	LAR	@	PIT	4	2	6	1.0	5	0	0	0	0	0	0
22	Justin Houston J. Houston	1	1	11/3/2019	IND	@	PIT	2	1	3	1.0	8	0	0	0	1	1	0
23	James Burgess J. Burgess	1	1	11/3/2019	NYJ	@	MIA	4	2	6	0.0	0	0	0	0	0	0	0
24	Bruce Irvin B. Irvin	1	1	10/27/2019	CAR	@	SF	5	0	5	2.0	13	0	0	0	0	0	0
25	Luke Kuechly L. Kuechly	1	1	9/12/2019	CAR	vs	TB	8	10	18	0.0	0	0	0	0	0	0	0

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Results may be incomplete. StatMuse has complete game-level data for safeties going back to the 1960 season.

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