| NAME | SEASON | TM | GP | RUSH YDS | ATT | RUSH AVG | RUSH YDS/G | RUSH TD | REC YDS | REC | TRG | REC AVG | REC YDS/G | REC TD | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Joe Mixon | 2018 |  CIN | 14 | 1,168 | 237 | 4.9 | 83.4 | 8 | 296 | 43 | 55 | 6.9 | 21.1 | 1 |
 | Derrick Henry | 2018 |  TEN | 16 | 1,059 | 215 | 4.9 | 66.2 | 12 | 99 | 15 | 18 | 6.6 | 6.2 | 0 |
 | Phillip Lindsay | 2018 |  DEN | 15 | 1,037 | 192 | 5.4 | 69.1 | 9 | 241 | 35 | 47 | 6.9 | 16.1 | 1 |
 | Nick Chubb | 2018 |  CLE | 16 | 996 | 192 | 5.2 | 62.3 | 8 | 149 | 20 | 29 | 7.5 | 9.3 | 2 |
 | Lamar Miller | 2018 |  HOU | 14 | 973 | 210 | 4.6 | 69.5 | 5 | 163 | 25 | 35 | 6.5 | 11.6 | 1 |
 | James Conner | 2018 |  PIT | 13 | 973 | 215 | 4.5 | 74.8 | 12 | 497 | 55 | 71 | 9.0 | 38.2 | 1 |
 | Sony Michel | 2018 |  NE | 13 | 931 | 209 | 4.5 | 71.6 | 6 | 50 | 7 | 11 | 7.1 | 3.8 | 0 |
 | Marlon Mack | 2018 |  IND | 12 | 908 | 195 | 4.7 | 75.7 | 9 | 103 | 17 | 26 | 6.1 | 8.6 | 1 |
 | Melvin Gordon | 2018 |  LAC | 12 | 885 | 175 | 5.1 | 73.8 | 10 | 490 | 50 | 66 | 9.8 | 40.8 | 4 |
 | Kareem Hunt | 2018 |  KC | 11 | 824 | 181 | 4.6 | 74.9 | 7 | 378 | 26 | 35 | 14.5 | 34.4 | 7 |
 | Doug Martin | 2018 |  OAK | 16 | 723 | 172 | 4.2 | 45.2 | 4 | 116 | 18 | 24 | 6.4 | 7.3 | 0 |
 | Frank Gore | 2018 |  MIA | 14 | 722 | 156 | 4.6 | 51.6 | 0 | 124 | 12 | 16 | 10.3 | 8.9 | 1 |
 | Gus Edwards | 2018 |  BAL | 11 | 718 | 137 | 5.2 | 65.3 | 2 | 20 | 2 | 2 | 10.0 | 1.8 | 0 |
 | Lamar Jackson | 2018 | BAL | 16 | 695 | 147 | 4.7 | 43.4 | 5 | 0 | 0 | 2 | 0.0 | 0 | |
| Isaiah Crowell | 2018 |  NYJ | 13 | 685 | 143 | 4.8 | 52.7 | 6 | 152 | 21 | 28 | 7.2 | 11.7 | 0 |
 | Josh Allen | 2018 |  BUF | 12 | 631 | 89 | 7.1 | 52.6 | 8 | 0 | 0 | 1 | 0.0 | 0 | |
 | Carlos Hyde | 2018 | TOT | 14 | 571 | 172 | 3.3 | 40.8 | 5 | 33 | 10 | 16 | 3.3 | 2.4 | 0 |
 | Austin Ekeler | 2018 | LAC | 14 | 554 | 106 | 5.2 | 39.6 | 3 | 404 | 39 | 53 | 10.4 | 28.9 | 3 |
 | Deshaun Watson | 2018 | HOU | 16 | 551 | 99 | 5.6 | 34.4 | 5 | 0 | 0 | 0 | 0.0 | 0 | |
 | Kenyan Drake | 2018 | MIA | 16 | 535 | 120 | 4.5 | 33.4 | 4 | 477 | 53 | 73 | 9.0 | 29.8 | 5 |
 | Royce Freeman | 2018 | DEN | 14 | 521 | 130 | 4.0 | 37.2 | 5 | 72 | 14 | 20 | 5.1 | 5.1 | 0 |
 | Dion Lewis | 2018 | TEN | 16 | 517 | 155 | 3.3 | 32.3 | 1 | 400 | 59 | 67 | 6.8 | 25.0 | 1 |
 | LeSean McCoy | 2018 | BUF | 14 | 514 | 161 | 3.2 | 36.7 | 3 | 238 | 34 | 46 | 7.0 | 17.0 | 0 |
| Alfred Blue | 2018 | HOU | 16 | 499 | 150 | 3.3 | 31.2 | 2 | 154 | 20 | 27 | 7.7 | 9.6 | 0 |
 | Leonard Fournette | 2018 |  JAX | 8 | 439 | 133 | 3.3 | 54.9 | 5 | 185 | 22 | 26 | 8.4 | 23.1 | 1 |