Penei Sewell was the youngest in a game in 2021. He was 20 years and 338 days old against the 49ers on September 12, 2021.

Interpreted as:

youngest NFL player in a regular-season game 2021

	NAME	Age	DATE	TM		OPP	YDS	TD	RUSH YDS	RUSH TD	REC YDS	REC TD	KR YDS	KR TD	PR YDS	PR TD
1	Penei Sewell P. Sewell	20-338	9/12/2021	DET	vs	SF	0	0	0	0	0	0	0	0	0	0
2	Kyle Pitts Sr. K. Pitts Sr.	20-341	9/12/2021	ATL	vs	PHI	31	0	0	0	31	0	0	0	0	0
3	Penei Sewell P. Sewell	20-346	9/20/2021	DET	@	GB	0	0	0	0	0	0	0	0	0	0
4	Kyle Pitts Sr. K. Pitts Sr.	20-348	9/19/2021	ATL	@	TB	73	0	0	0	73	0	0	0	0	0
5	Penei Sewell P. Sewell	20-352	9/26/2021	DET	vs	BAL	0	0	0	0	0	0	0	0	0	0
6	Kyle Pitts Sr. K. Pitts Sr.	20-355	9/26/2021	ATL	@	NYG	35	0	0	0	35	0	0	0	0	0
7	Penei Sewell P. Sewell	20-359	10/3/2021	DET	@	CHI	0	0	0	0	0	0	0	0	0	0
8	Kyle Pitts Sr. K. Pitts Sr.	20-362	10/3/2021	ATL	vs	WAS	50	0	0	0	50	0	0	0	0	0
9	Penei Sewell P. Sewell	21-001	10/10/2021	DET	@	MIN	0	0	0	0	0	0	0	0	0	0
10	Kyle Pitts Sr. K. Pitts Sr.	21-004	10/10/2021	ATL	vs	NYJ	119	1	0	0	119	1	0	0	0	0
11	Anthony Schwartz A. Schwartz	21-007	9/12/2021	CLE	@	KC	86	0	17	0	69	0	0	0	0	0
12	Penei Sewell P. Sewell	21-008	10/17/2021	DET	vs	CIN	0	0	0	0	0	0	0	0	0	0
13	Anthony Schwartz A. Schwartz	21-014	9/19/2021	CLE	vs	HOU	0	0	0	0	0	0	0	0	0	0
14	Penei Sewell P. Sewell	21-015	10/24/2021	DET	@	LAR	0	0	0	0	0	0	0	0	0	0
15	Kyle Pitts Sr. K. Pitts Sr.	21-018	10/24/2021	ATL	@	MIA	163	0	0	0	163	0	0	0	0	0
16	Anthony Schwartz A. Schwartz	21-021	9/26/2021	CLE	vs	CHI	0	0	0	0	0	0	0	0	0	0
17	Penei Sewell P. Sewell	21-022	10/31/2021	DET	vs	PHI	0	0	0	0	0	0	0	0	0	0
18	Kyle Pitts Sr. K. Pitts Sr.	21-025	10/31/2021	ATL	vs	CAR	13	0	0	0	13	0	0	0	0	0
19	Anthony Schwartz A. Schwartz	21-028	10/3/2021	CLE	@	MIN	26	0	0	0	0	0	26	0	0	0
20	Kyle Pitts Sr. K. Pitts Sr.	21-032	11/7/2021	ATL	@	NO	62	0	0	0	62	0	0	0	0	0
21	Anthony Schwartz A. Schwartz	21-035	10/10/2021	CLE	@	LAC	109	0	0	0	0	0	109	0	0	0
22	Penei Sewell P. Sewell	21-036	11/14/2021	DET	@	PIT	0	0	0	0	0	0	0	0	0	0
23	Kyle Pitts Sr. K. Pitts Sr.	21-039	11/14/2021	ATL	@	DAL	60	0	0	0	60	0	0	0	0	0
24	Anthony Schwartz A. Schwartz	21-042	10/17/2021	CLE	vs	ARI	62	0	-3	0	11	0	54	0	0	0
25	Penei Sewell P. Sewell	21-043	11/21/2021	DET	@	CLE	0	0	0	0	0	0	0	0	0	0

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Penei Sewell was the youngest in a game in 2021. He was 20 years and 338 days old against the 49ers on September 12, 2021.

Interpreted as:

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