The San Francisco 49ers are 20-22 against the spread as favorites with a spread of -6.5 or below since 2019.
| TEAM | DATE | ATS | TM | OPP | RESULT | SPREAD | ATS DIFF | O/U | O/U DIFF | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | 49ers | 9/22/2019 | 0-1 |  SF | -301 | vs |  PIT | +242 | W 24-20 | -6.5 | -2.5 (N) | 44 | 0 (P) | 3 | 26 | 436 | 239 | 54.5 | |
| 2 | | 49ers | 10/20/2019 | 0-1 | SF | -425 | @ |  WAS | +332 | W 9-0 | -10 | -1 (N) | 39 | -30 (U) | 0 | 17 | 283 | 154 | 43.8 | 50.0 |
| 3 | | 49ers | 10/31/2019 | 0-1 | SF | -521 | @ |  ARI | +389 | W 28-25 | -10.5 | -7.5 (N) | 43.5 | +9.5 (O) | 4 | 21 | 411 | 357 | 64.7 | 100.0 |
| 4 | | 49ers | 11/11/2019 | 0-1 | SF | -272 | vs |  SEA | +221 | L 24-27 | -6.5 | -9.5 (N) | 47 | +4 (O) | 2 | 21 | 302 | 336 | 40.0 | 0.0 |
| 5 | | 49ers | 11/17/2019 | 1-0 | SF | -470 | vs | ARI | +351 | W 36-26 | -9.5 | +0.5 (Y) | 44 | +18 (O) | 5 | 26 | 442 | 266 | 46.2 | 0.0 |
| 6 | | 49ers | 12/15/2019 | 0-1 | SF | -460 | vs |  ATL | +350 | L 22-29 | -10 | -17 (N) | 50 | +1 (O) | 2 | 20 | 313 | 290 | 33.3 | 100.0 |
| 7 | | 49ers | 12/21/2019 | 0-1 | SF | -329 | vs |  LAR | +256 | W 34-31 | -7 | -4 (N) | 45.5 | +19.5 (O) | 4 | 19 | 334 | 395 | 40.0 | |
| 8 | | 49ers | 1/11/2020 | 1-0 | SF | -352 | vs |  MIN | +275 | W 27-10 | -7.5 | +9.5 (Y) | 44.5 | -7.5 (U) | 3 | 21 | 308 | 147 | 41.7 | 0.0 |
| 9 | | 49ers | 1/19/2020 | 1-0 | SF | -375 | vs |  GB | +294 | W 37-20 | -8 | +9 (Y) | 46.5 | +10.5 (O) | 4 | 19 | 354 | 358 | 40.0 | |
| 10 | | 49ers | 9/13/2020 | 0-1 | SF | -312 | vs | ARI | +245 | L 20-24 | -6.5 | -10.5 (N) | 48 | -4 (U) | 2 | 18 | 366 | 404 | 18.2 | 0.0 |
| 11 | | 49ers | 9/20/2020 | 1-0 | SF | -325 | @ |  NYJ | +265 | W 31-13 | -7 | +11 (Y) | 41.5 | +2.5 (O) | 4 | 17 | 359 | 277 | 53.8 | |
| 12 | | 49ers | 10/4/2020 | 0-1 | SF | -351 | vs |  PHI | +283 | L 20-25 | -8.5 | -13.5 (N) | 45.5 | -0.5 (U) | 3 | 25 | 417 | 267 | 45.5 | 0.0 |
| 13 | | 49ers | 10/11/2020 | 0-1 | SF | -390 | vs |  MIA | +314 | L 17-43 | -8.5 | -34.5 (N) | 50.5 | +9.5 (O) | 2 | 19 | 259 | 436 | 20.0 | 0.0 |
| 14 | | 49ers | 9/12/2021 | 1-0 | SF | -371 | @ |  DET | +285 | W 41-33 | -7.5 | +0.5 (Y) | 45 | +29 (O) | 5 | 21 | 442 | 430 | 33.3 | |
| 15 | | 49ers | 11/21/2021 | 1-0 | SF | -290 | @ |  JAX | +233 | W 30-10 | -6.5 | +13.5 (Y) | 45.5 | -5.5 (U) | 3 | 25 | 333 | 200 | 50.0 | 100.0 |
| 16 | | 49ers | 12/19/2021 | 1-0 | SF | -408 | vs | ATL | +311 | W 31-13 | -9 | +9 (Y) | 47.5 | -3.5 (U) | 4 | 23 | 397 | 275 | 54.5 | |
| 17 | | 49ers | 1/2/2022 | 1-0 | SF | -740 | vs |  HOU | +507 | W 23-7 | -13.5 | +2.5 (Y) | 44.5 | -14.5 (U) | 2 | 19 | 416 | 222 | 38.5 | 0.0 |
| 18 | | 49ers | 9/11/2022 | 0-1 | SF | -285 | @ |  CHI | +230 | L 10-19 | -6.5 | -15.5 (N) | 38 | -9 (U) | 1 | 17 | 331 | 204 | 47.1 | 0.0 |
| 19 | | 49ers | 9/18/2022 | 1-0 | SF | -394 | vs | SEA | +306 | W 27-7 | -8.5 | +11.5 (Y) | 39.5 | -5.5 (U) | 3 | 25 | 373 | 216 | 40.0 | 66.7 |
| 20 | | 49ers | 11/13/2022 | 0-1 | SF | -361 | vs |  LAC | +284 | W 22-16 | -8 | -2 (N) | 45.5 | -7.5 (U) | 2 | 22 | 387 | 238 | 52.9 | 100.0 |
| 21 | | 49ers | 11/21/2022 | 1-0 | SF | -442 | @ | ARI | +341 | W 38-10 | -9.5 | +18.5 (Y) | 43 | +5 (O) | 5 | 21 | 387 | 314 | 54.5 | |
| 22 | | 49ers | 11/27/2022 | 1-0 | SF | -426 | vs |  NO | +325 | W 13-0 | -8.5 | +4.5 (Y) | 43.5 | -30.5 (U) | 1 | 21 | 317 | 260 | 38.5 | 50.0 |
| 23 | | 49ers | 12/24/2022 | 1-0 | SF | -299 | vs |  WAS | +240 | W 37-20 | -6.5 | +10.5 (Y) | 37 | +20 (O) | 4 | 14 | 371 | 349 | 36.4 | 50.0 |
| 24 | | 49ers | 1/1/2023 | 0-1 | SF | -472 | @ |  LV | +359 | W 37-34 | -10 | -7 (N) | 41 | +30 (O) | 4 | 27 | 454 | 500 | 50.0 | |
| 25 | | 49ers | 1/8/2023 | 1-0 | SF | -1057 | vs | ARI | +693 | W 38-13 | -14.5 | +10.5 (Y) | 39.5 | +11.5 (O) | 5 | 21 | 311 | 255 | 46.2 | 0.0 |
| Average | 1.1 | -9.1 | 3.1 | 21.5 | 378.9 | 304.8 | 45.8 | 1.4 | ||||||||||||
| Total | 20-22 | -383.5 | 132 | 904 | 15,913 | 12,801 | 45.8 | 33.3 | ||||||||||||
StatMuse has team, game-level data for spread records and spreads going back to the 1979 season.
More 49ers Stats
Team Rankings
PPG
19.7
23rd
OPP PPG
16.3
3rd
RUSH YDS/G
89.7
26th
PASS YDS/G
280.0
3rd
NFL 2025 Leaders
NFL 2025 Rankings
NFL Fantasy 2025
NFL 2025 Betting
NFL 2025 Division Standings
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
| Eagles | 3 | 0 | 0 | 1.000 |
| Commanders | 2 | 1 | 0 | .667 |
| NFC North | W | L | T | PCT |
| Packers | 2 | 1 | 0 | .667 |
| Vikings | 2 | 1 | 0 | .667 |
| NFC South | W | L | T | PCT |
 Buccaneers | 3 | 0 | 0 | 1.000 |
 Panthers | 1 | 2 | 0 | .333 |
| NFC West | W | L | T | PCT |
| 49ers | 3 | 0 | 0 | 1.000 |
 Rams | 2 | 1 | 0 | .667 |
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