The San Francisco 49ers have a record of 10-6 against the Titans in the regular season and playoffs all-time.
| TEAM | DATE | TM | OPP | RESULT | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | 49ers | 11/15/1970 | @ | W 30-20 | 4 | 17 | 376 | 268 | ||||
| 2 | | 49ers | 12/7/1975 | vs | L 13-27 | 1 | 11 | 200 | 279 | ||||
| 3 | | 49ers | 9/17/1978 | @ | L 19-20 | 2 | 18 | 382 | 332 | ||||
| 4 | | 49ers | 12/13/1981 | vs | W 28-6 | 4 | 22 | 414 | 186 | ||||
| 5 | | 49ers | 10/21/1984 | @ | W 34-21 | 4 | 25 | 517 | 432 | ||||
| 6 | | 49ers | 11/8/1987 | vs | W 27-20 | 3 | 33 | 443 | 269 | ||||
| 7 | | 49ers | 10/7/1990 | @ | W 24-21 | 3 | 17 | 383 | 256 | ||||
| 8 | | 49ers | 12/25/1993 | vs | L 7-10 | 1 | 20 | 337 | 311 | 46.2 | |||
| 9 | | 49ers | 10/27/1996 | @ | W 10-9 | 1 | 12 | 238 | 184 | 43.8 | 0.0 | ||
| 10 | | 49ers | 10/3/1999 | vs | W 24-22 | 3 | 17 | 329 | 392 | 38.5 | |||
| 11 | | 49ers | 11/27/2005 | @ | L 22-33 | 3 | 15 | 261 | 461 | 20.0 | 100.0 | ||
| 12 | | 49ers | 11/8/2009 | vs | L 27-34 | 3 | 25 | 358 | 315 | 30.8 | 100.0 | ||
| 13 | | 49ers | 10/20/2013 | @ | W 31-17 | 4 | 19 | 349 | 368 | 50.0 | |||
| 14 | | 49ers | 12/17/2017 | vs | W 25-23 | 1 | 23 | 414 | 328 | 50.0 | |||
| 15 | | 49ers | 12/23/2021 | @ | L 17-20 | 2 | 22 | 389 | 278 | 37.5 | 50.0 | ||
| 16 | | 49ers | 12/14/2025 | vs | W 37-24 | 4 | 28 | 430 | 306 | 60.0 | 100.0 | ||
| Average | 2.7 | 20.3 | 363.8 | 310.3 | |||||||||
| Total | 43 | 324 | 5,820 | 4,965 |
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More 49ers Stats
Team Leaders 
PASS
1,980
Purdy
RUSH
457
McCaffrey
REC
483
Kittle
Team Rankings
PPG
29.4
3rd
OPP PPG
19.5
6th
RUSH YDS/G
135.3
7th
PASS YDS/G
247.5
14th
Rams
Seahawks
Cardinals
DAL
MIN
NYG
NFL 2026 Leaders
NFL 2026 Rankings
NFL Fantasy 2026
NFL 2026 Betting
NFL 2026 Standings
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
5 | 2 | 1 | .688 | |
4 | 5 | 0 | .444 | |
2 | 5 | 1 | .313 | |
2 | 7 | 0 | .222 | |
| NFC North | W | L | T | PCT |
7 | 2 | 0 | .778 | |
6 | 2 | 0 | .750 | |
6 | 2 | 0 | .750 | |
6 | 3 | 0 | .667 | |
| NFC South | W | L | T | PCT |
3 | 5 | 0 | .375 | |
3 | 5 | 0 | .375 | |
3 | 6 | 0 | .333 | |
3 | 6 | 0 | .333 | |
| NFC West | W | L | T | PCT |
7 | 1 | 0 | .875 | |
5 | 4 | 0 | .556 | |
5 | 4 | 0 | .556 | |
3 | 6 | 0 | .333 |
Commanders
Eagles
Bears
Lions
Packers
Panthers
Saints
Buccaneers
Falcons| AFC East | W | L | T | PCT |
|---|---|---|---|---|
7 | 1 | 0 | .875 | |
5 | 4 | 0 | .556 | |
2 | 7 | 0 | .222 | |
1 | 7 | 0 | .125 | |
| AFC North | W | L | T | PCT |
6 | 2 | 0 | .750 | |
6 | 2 | 0 | .750 | |
5 | 4 | 0 | .556 | |
4 | 5 | 0 | .444 | |
| AFC South | W | L | T | PCT |
6 | 2 | 0 | .750 | |
3 | 5 | 0 | .375 | |
2 | 7 | 0 | .222 | |
1 | 7 | 0 | .125 | |
| AFC West | W | L | T | PCT |
7 | 2 | 0 | .778 | |
6 | 2 | 0 | .750 | |
4 | 5 | 0 | .444 | |
0 | 8 | 0 | .000 |
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