The San Francisco 49ers are 25-11-1 in the regular-season and playoffs against the Lions at home all-time.
| TEAM | DATE | REC | TM | OPP | RESULT | W% | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | 49ers | 10/22/1950 | 1-0 |  SF | vs |  DET | W 28-27 | 1.000 | 4 | 18 | 295 | 327 | ||
| 2 | | 49ers | 12/16/1951 | 1-0 | SF | vs | DET | W 21-17 | 1.000 | 3 | 17 | 265 | 331 | ||
| 3 | | 49ers | 9/28/1952 | 1-0 | SF | vs | DET | W 17-3 | 1.000 | 2 | 19 | 324 | 247 | ||
| 4 | | 49ers | 10/25/1953 | 0-1 | SF | vs | DET | L 10-14 | .000 | 1 | 25 | 351 | 239 | ||
| 5 | | 49ers | 10/24/1954 | 1-0 | SF | vs | DET | W 37-31 | 1.000 | 5 | 23 | 424 | 443 | ||
| 6 | | 49ers | 10/30/1955 | 1-0 | SF | vs | DET | W 38-21 | 1.000 | 5 | 26 | 438 | 401 | ||
| 7 | | 49ers | 11/4/1956 | 0-1 | SF | vs | DET | L 13-17 | .000 | 1 | 15 | 246 | 283 | ||
| 8 | | 49ers | 11/3/1957 | 1-0 | SF | vs | DET | W 35-31 | 1.000 | 5 | 26 | 379 | 416 | ||
| 9 | | 49ers | 12/22/1957 | 0-1 | SF | vs | DET | L 27-31 | .000 | 3 | 20 | 351 | 324 | ||
| 10 | | 49ers | 11/2/1958 | 1-0 | SF | vs | DET | W 24-21 | 1.000 | 3 | 15 | 411 | 171 | ||
| 11 | | 49ers | 11/1/1959 | 1-0 | SF | vs | DET | W 33-7 | 1.000 | 4 | 20 | 394 | 183 | ||
| 12 | | 49ers | 11/6/1960 | 0-1 | SF | vs | DET | L 0-24 | .000 | 0 | 14 | 232 | 313 | ||
| 13 | | 49ers | 11/5/1961 | 0-0-1 | SF | vs | DET | T 20-20 | .500 | 2 | 14 | 326 | 402 | ||
| 14 | | 49ers | 11/11/1962 | 0-1 | SF | vs | DET | L 24-38 | .000 | 3 | 18 | 288 | 437 | ||
| 15 | | 49ers | 11/3/1963 | 0-1 | SF | vs | DET | L 7-45 | .000 | 1 | 9 | 133 | 509 | ||
| 16 | | 49ers | 9/13/1964 | 0-1 | SF | vs | DET | L 17-26 | .000 | 2 | 13 | 219 | 372 | ||
| 17 | | 49ers | 12/5/1965 | 1-0 | SF | vs | DET | W 17-14 | 1.000 | 2 | 20 | 357 | 300 | ||
| 18 | | 49ers | 10/23/1966 | 1-0 | SF | vs | DET | W 27-24 | 1.000 | 3 | 23 | 359 | 314 | ||
| 19 | | 49ers | 10/29/1967 | 0-1 | SF | vs | DET | L 3-45 | .000 | 0 | 10 | 173 | 391 | ||
| 20 | | 49ers | 11/2/1969 | 0-1 | SF | vs | DET | L 14-26 | .000 | 2 | 14 | 282 | 125 | ||
| 21 | | 49ers | 12/19/1971 | 1-0 | SF | vs | DET | W 31-27 | 1.000 | 4 | 20 | 357 | 310 | ||
| 22 | | 49ers | 11/2/1975 | 0-1 | SF | vs | DET | L 17-28 | .000 | 2 | 19 | 296 | 286 | ||
| 23 | | 49ers | 10/23/1977 | 1-0 | SF | vs | DET | W 28-7 | 1.000 | 4 | 16 | 300 | 119 | ||
| 24 | | 49ers | 12/31/1983 | 1-0 | SF | vs | DET | W 24-23 | 1.000 | 3 | 20 | 291 | 412 | ||
| 25 | | 49ers | 10/2/1988 | 1-0 | SF | vs | DET | W 20-13 | 1.000 | 2 | 19 | 339 | 297 | ||
| Average | .689 | 2.9 | 19.9 | 335.2 | 313.8 | ||||||||||
| Total | 25-11-1 | .689 | 109 | 735 | 12,401 | 11,612 | |||||||||
More 49ers Stats
Team Rankings
PPG
21.2
22nd
OPP PPG
19.6
7th
RUSH YDS/G
85.2
29th
PASS YDS/G
298.2
1st
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| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles | 4 | 2 | 0 | .667 |
 Commanders | 3 | 2 | 0 | .600 |
| NFC North | W | L | T | PCT |
| Lions | 4 | 1 | 0 | .800 |
 Packers | 2 | 1 | 1 | .625 |
| NFC South | W | L | T | PCT |
 Buccaneers | 4 | 1 | 0 | .800 |
 Falcons | 2 | 2 | 0 | .500 |
| NFC West | W | L | T | PCT |
| 49ers | 4 | 1 | 0 | .800 |
 Rams | 4 | 2 | 0 | .667 |
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