Derrick Thomas has the most sacks in a game, with 7 sacks against the Seahawks on November 11, 1990.
Interpreted as:
most defensive sacks by one player in one regular-season game all-time| NAME | SCK | DATE | TM | OPP | TKL | AST | COMB | SCKY | INT | INT YDS | INT TD | FF | FR | FR TD | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | D. Thomas | 7.0 | 11/11/1990 |  KC | vs |  SEA | 0 | 0 | 0 | 0 | ||||||
| 2 |  | K. Mack | 6.0 | 10/1/2023 |  LAC | vs |  LV | 8 | 2 | 10 | 45 | 0 | 0 | 0 | 2 | 0 | 0 |
| 3 |  | A. Clayborn | 6.0 | 11/12/2017 |  ATL | vs |  DAL | 6 | 0 | 6 | 32 | 0 | 0 | 0 | 2 | 1 | 0 |
| 4 | | O. Umenyiora | 6.0 | 9/30/2007 |  NYG | vs |  PHI | 6 | 0 | 6 | 38 | 0 | 0 | 0 | 2 | 0 | 0 |
| 5 | | D. Thomas | 6.0 | 9/6/1998 | KC | vs | OAK | 0 | 0 | 0 | 0 | ||||||
| 6 | | F. Dean | 6.0 | 11/13/1983 |  SF | vs |  NO | 0 | 0 | 0 | 0 | ||||||
| 7 | | A. Smith | 5.5 | 11/19/2012 | SF | vs |  CHI | 6 | 1 | 7 | 45 | 0 | 0 | 0 | 2 | 0 | 0 |
| 8 | | B. Gay | 5.5 | 9/4/1983 |  DET | @ |  TB | 0 | 0 | 0 | 0 | ||||||
| 9 |  | C. Jones | 5.0 | 9/12/2021 |  ARI | @ |  TEN | 6 | 0 | 6 | 46 | 0 | 0 | 0 | 2 | 0 | 0 |
| 10 | | H. Reddick | 5.0 | 12/13/2020 | ARI | @ | NYG | 5 | 0 | 5 | 43 | 0 | 0 | 0 | 3 | 0 | 0 |
| 11 |  | K. Mack | 5.0 | 12/13/2015 | OAK | @ |  DEN | 6 | 1 | 7 | 32 | 0 | 0 | 0 | 1 | 0 | 0 |
| 12 | | A. Odom | 5.0 | 9/20/2009 |  CIN | @ |  GB | 6 | 0 | 6 | 31 | 0 | 0 | 0 | 0 | 0 | 0 |
| 13 | | V. Holliday | 5.0 | 12/22/2002 | GB | vs |  BUF | 5 | 2 | 7 | 28 | 0 | 0 | 0 | 3 | 0 | 0 |
| 14 | | C. Smith | 5.0 | 10/12/1997 | ATL | @ | NO | 0 | 0 | 0 | 0 | ||||||
| 15 | | G. Jeter | 5.0 | 9/18/1988 |  RAM | @ | RAI | 0 | 0 | 0 | 0 | ||||||
| 16 | | L. O'Neal | 5.0 | 11/16/1986 | SD | vs | DAL | 0 | 0 | 0 | 0 | ||||||
| 17 | | J. Jeffcoat | 5.0 | 11/10/1985 | DAL | @ |  WAS | 0 | 0 | 0 | 0 | ||||||
| 18 | | R. Holloway | 5.0 | 9/16/1984 |  MIN | vs | ATL | 0 | 0 | 0 | 0 | ||||||
| 19 |  | H. Long | 5.0 | 10/2/1983 | RAI | @ | WAS | 0 | 0 | 0 | 0 | ||||||
| 20 |  | A. Hutchinson | 4.5 | 9/15/2024 | DET | vs | TB | 4 | 1 | 5 | 37 | 0 | 0 | 0 | 1 | 0 | 0 |
| 21 |  | M. Garrett | 4.5 | 9/26/2021 |  CLE | vs | CHI | 6 | 1 | 7 | 24.5 | 0 | 0 | 0 | 0 | 0 | 0 |
| 22 |  | J. Houston | 4.5 | 9/19/2013 | KC | @ | PHI | 6 | 1 | 7 | 28 | 0 | 0 | 0 | 1 | 2 | 0 |
| 23 | | M. Williams | 4.5 | 9/15/2013 | BUF | vs |  CAR | 5 | 1 | 6 | 24.5 | 0 | 0 | 0 | 0 | 0 | 0 |
| 24 | | C. Wake | 4.5 | 9/30/2012 |  MIA | @ | ARI | 4 | 1 | 5 | 30.5 | 0 | 0 | 0 | 0 | 0 | 0 |
| 25 |  | J. Allen | 4.5 | 10/5/2009 | MIN | vs | GB | 6 | 1 | 7 | 19.5 | 0 | 0 | 0 | 1 | 0 | 0 |
StatMuse has game-level data for sacks going back to the 1982 season.
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