Devon Toews had the highest plus/minus by a defenseman in 2021-22, at +52.

	NAME	+/-	SEASON	TM	GP	G	A	P	PIM	PPG	PPA	SHG	SHA	GWG	OTG	S	S%	FOW	FO	FOW%	HIT	BKS	TKA	GVA	TOI/GP
1	Devon Toews D. Toews	+52	2021-22	COL	66	13	44	57	20	2	10	0	0	3	1	158	8.2	0	0		54	85	45	34	25:22
2	Cale Makar C. Makar	+48	2021-22	COL	77	28	58	86	26	9	25	0	0	6	3	240	11.7	0	0		95	110	49	40	25:40
3	Justin Faulk J. Faulk	+41	2021-22	STL	76	16	31	47	43	1	6	0	0	6	1	167	9.6	0	0		149	101	37	40	23:12
4	Gustav Forsling G. Forsling	+41	2021-22	FLA	71	10	27	37	18	0	0	0	0	1	1	145	6.9	0	0		45	86	51	53	21:13
5	Alex Goligoski A. Goligoski	+41	2021-22	MIN	72	2	28	30	34	0	4	0	0	0	0	80	2.5	0	0		56	96	6	31	18:56
6	MacKenzie Weegar M. Weegar	+40	2021-22	FLA	80	8	36	44	81	1	2	1	1	2	0	203	3.9	0	0		179	156	74	85	23:22
7	Aaron Ekblad A. Ekblad	+38	2021-22	FLA	61	15	42	57	26	3	17	0	3	2	2	180	8.3	0	0		62	69	43	73	24:55
8	Jaccob Slavin J. Slavin	+35	2021-22	CAR	79	4	38	42	10	1	6	0	2	0	0	165	2.4	0	0		50	121	74	43	23:32
9	Chris Tanev C. Tanev	+35	2021-22	CGY	82	6	22	28	22	0	0	0	0	3	0	88	6.8	0	0		52	158	29	57	20:28
10	Oliver Kylington O. Kylington	+34	2021-22	CGY	73	9	22	31	14	1	2	0	0	2	0	138	6.5	0	0		40	79	24	56	18:10
11	Jared Spurgeon J. Spurgeon	+32	2021-22	MIN	65	10	30	40	10	0	14	0	0	2	2	116	8.6	0	0		44	83	13	14	21:09
12	Nick Jensen N. Jensen	+32	2021-22	WSH	76	5	16	21	21	0	0	0	0	1	0	88	5.7	0	0		135	92	23	44	19:21
13	Charlie McAvoy C. McAvoy	+31	2021-22	BOS	78	10	46	56	66	4	17	1	0	5	1	166	6.0	0	0		155	130	29	65	24:38
14	Tony DeAngelo T. DeAngelo	+30	2021-22	CAR	64	10	41	51	56	2	18	0	0	2	0	151	6.6	0	0		41	59	27	39	19:49
15	Rasmus Andersson R. Andersson	+30	2021-22	CGY	82	4	46	50	28	2	17	0	1	1	0	152	2.6	0	0		63	125	24	44	22:40
16	Radko Gudas R. Gudas	+27	2021-22	FLA	77	3	13	16	105	0	0	1	0	0	0	100	3.0	0	0		355	118	28	57	18:01
17	Noah Hanifin N. Hanifin	+27	2021-22	CGY	81	10	38	48	19	1	12	0	1	1	0	189	5.3	0	0		63	84	38	62	21:18
18	Alexandre Carrier A. Carrier	+26	2021-22	NSH	77	3	27	30	50	1	3	0	1	0	0	95	3.2	0	1	0.0	95	124	27	39	20:59
19	Victor Hedman V. Hedman	+26	2021-22	TBL	82	20	65	85	36	6	32	0	0	6	1	219	9.1	0	0		93	129	52	56	25:05
20	Dmitry Orlov D. Orlov	+25	2021-22	WSH	76	12	23	35	44	2	2	0	0	4	1	127	9.4	0	0		124	94	37	44	20:58
21	Jacob Trouba J. Trouba	+25	2021-22	NYR	81	11	28	39	88	1	3	0	2	1	0	204	5.4	0	0		207	177	24	63	22:26
22	Jan Rutta J. Rutta	+25	2021-22	TBL	76	3	15	18	47	0	0	0	0	0	0	86	3.5	0	0		93	71	6	18	16:23
23	Brian Dumoulin B. Dumoulin	+24	2021-22	PIT	76	3	15	18	24	0	0	0	0	0	0	91	3.3	0	0		88	139	34	46	21:49
24	Torey Krug T. Krug	+23	2021-22	STL	64	9	34	43	48	3	16	1	0	1	0	119	7.6	0	0		53	70	16	32	20:34
25	Dmitry Kulikov D. Kulikov	+23	2021-22	MIN	80	7	17	24	39	0	0	0	0	2	1	74	9.5	0	0		100	103	16	31	18:12