Manchester United had their highest goal differential in a Premier League match against Liverpool on April 5, 2003, with a differential of 4 goals.

man utd biggest win in a game against liverpool in2009

	CLUB	GD	DATE		OPP	RESULT	G	SH	SOT	PASS	PASS-ATT	POSS%	FOUL	YC	RC	SUBS
1	Man United	4	4/5/2003	vs	Liverpool	W 4-0	4							1	0	3
2	Man United	3	12/14/2014	vs	Liverpool	W 3-0	3	11	6	417	514	54.7	13	4	0	3
3	Man United	3	3/23/2008	vs	Liverpool	W 3-0	3	24	10		605	64.7	11	1	0	2
4	Man United	2	9/12/2015	vs	Liverpool	W 3-1	3	9	3	479	566	55.7	6	1	0	3
5	Man United	2	10/22/2006	vs	Liverpool	W 2-0	2	11	7		512	56.1	14	1	0	2
6	Man United	2	9/24/1998	vs	Liverpool	W 2-0	2							4	0	2
7	Man United	2	12/6/1997	@	Liverpool	W 3-1	3							2	0	0
8	Man United	2	4/19/1997	@	Liverpool	W 3-1	3							2	0	1
9	Man United	2	9/17/1994	vs	Liverpool	W 2-0	2							3	0	1
10	Man United	1	10/19/2025	@	Liverpool	W 2-1	2	12	4	207	299	36.7	14	2	0	5
11	Man United	1	8/22/2022	vs	Liverpool	W 2-1	2	12	4	183	270	29.8	11	3	0	5
12	Man United	1	3/10/2018	vs	Liverpool	W 2-1	2	5	2	194	283	32.1	10	2	0	3
13	Man United	1	1/17/2016	@	Liverpool	W 1-0	1	7	1	323	437	46.7	18	2	0	3
14	Man United	1	3/22/2015	@	Liverpool	W 2-1	2	6	4	464	569	58.3	17	2	0	3
15	Man United	1	1/13/2013	vs	Liverpool	W 2-1	2	15	5		404	46.0	14	1	0	3
16	Man United	1	9/23/2012	@	Liverpool	W 2-1	2	8	3		420	48.0	7	2	0	3
17	Man United	1	2/11/2012	vs	Liverpool	W 2-1	2	11	6		593	54.9	10	1	0	0
18	Man United	1	9/19/2010	vs	Liverpool	W 3-2	3	19	5		470	49.5	15	4	0	3
19	Man United	1	3/21/2010	vs	Liverpool	W 2-1	2	12	5		535	55.2	11	2	0	2
20	Man United	1	12/16/2007	@	Liverpool	W 1-0	1	6	2		289	43.4	15	3	0	2
21	Man United	1	3/3/2007	@	Liverpool	W 1-0	1	6	3		374	42.9	13	2	1	3
22	Man United	1	1/22/2006	vs	Liverpool	W 1-0	1							2	0	1
23	Man United	1	1/15/2005	@	Liverpool	W 1-0	1							3	1	3
24	Man United	1	9/20/2004	vs	Liverpool	W 2-1	2							1	0	1
25	Man United	1	11/9/2003	@	Liverpool	W 2-1	2							2	0	1