Ryan Giggs has made the most career appearances by a Man United player in the Premier League, with 632 appearances.

most premier league games by a player for manchester united

	NAME	M	MIN	START	G	G/M	A	G+A	PK	FK	SH	SOT	WOOD	TCH	TCH-BOX	OFF
1	Ryan Giggs R. Giggs	632	46,437	522	109	0.17	163	272	2
2	Paul Scholes P. Scholes	499	36,129	404	107	0.21	54	161	1
3	David De Gea D. De Gea	415	37,289	415	0	0.00	0	0	0
4	Gary Neville G. Neville	400	33,573	380	5	0.01	35	40	0
5	Wayne Rooney W. Rooney	393	31,719	354	183	0.47	90	273	20
6	Roy Keane R. Keane	326	27,299	309	33	0.10	31	64	0
7	Michael Carrick M. Carrick	316	23,947	266	17	0.05	21	38	0
8	Rio Ferdinand R. Ferdinand	312	27,214	305	7	0.02	6	13	0
9	Denis Irwin D. Irwin	296	25,226	286	18	0.06	23	41	7
10	Marcus Rashford M. Rashford	287	19,680	217	87	0.30	40	127	8	1	571	251	16	10,009	1,220	123
11	Patrice Evra P. Evra	273	23,096	265	7	0.03	21	28	0
12	Nicky Butt N. Butt	270	18,356	210	21	0.08	19	40	0
13	David Beckham D. Beckham	265	21,566	237	62	0.23	80	142	2
14	Phil Neville P. Neville	263	18,998	209	5	0.02	11	16	0
15	John O'Shea J. O'Shea	256	17,274	188	10	0.04	12	22	0
16	Peter Schmeichel P. Schmeichel	252	22,375	252	0	0.00	3	3	0
17	Mikaël Silvestre M. Silvestre	249	19,933	225	6	0.02	18	24	0
18	Antonio Valencia A. Valencia	241	18,752	203	17	0.07	39	56	0
19	Cristiano Ronaldo C. Ronaldo	236	17,523	188	103	0.44	37	140	14
20	Ole Gunnar Solskjær O. Gunnar Solskjær	235	13,924	151	91	0.39	37	128	0
21	Wes Brown W. Brown	232	18,310	203	3	0.01	8	11	0
22	Darren Fletcher D. Fletcher	223	15,529	179	18	0.08	20	38	0
23	Luke Shaw L. Shaw	212	16,705	195	3	0.01	17	20	0	0	89	31	1	14,812	236	13
24	Nemanja Vidić N. Vidić	211	18,083	205	15	0.07	3	18	0
25	Bruno Fernandes B. Fernandes	209	18,135	205	64	0.31	56	120	23	3	574	213	24	15,571	645	39