Gianluigi Buffon has made the most career appearances in Serie A, with 657 appearances.

most serie a appearances by a player of all-time

	NAME	M	MIN	START	G	G/M	A	G+A	PK
1	Gianluigi Buffon G. Buffon	657	58,536	655	0	0.00	0	0	0
2	Paolo Maldini P. Maldini	647	56,495	640	29	0.04			0
3	Francesco Totti F. Totti	618	47,054	540	250	0.40	46	296	71
4	Javier Zanetti J. Zanetti	615	53,018	589	12	0.02	6	18	0
5	Gianluca Pagliuca G. Pagliuca	592	53,150	592	0	0.00			0
6	Dino Zoff D. Zoff	570	51,274	570	0	0.00			0
7	Samir Handanovič S. Handanovič	566	50,577	565	0	0.00	0	0	0
8	Pietro Vierchowod P. Vierchowod	562	49,531	557	38	0.07			0
9	Fabio Quagliarella F. Quagliarella	556	38,059	432	182	0.33	34	216	32
10	Roberto Mancini R. Mancini	541	43,935	497	156	0.29			22
11	Silvio Piola S. Piola	537	48,070	537	274	0.51			24
12	Enrico Albertosi E. Albertosi	532	47,400	531	0	0.00			0
13	Gianni Rivera G. Rivera	526	46,999	525	129	0.25			27
14	Giuseppe Bergomi G. Bergomi	519	45,012	510	23	0.04			0
15	Alberto Gilardino A. Gilardino	514	36,821	406	188	0.37	13	201	16
16	Andrea Consigli A. Consigli	510	45,538	510	0	0.00	0	0	0
17	Antonio Candreva A. Candreva	502	36,702	424	85	0.17	79	164	22
18	Ciro Ferrara C. Ferrara	499	41,455	469	27	0.05			0
19	Giovanni Galli G. Galli	496	44,060	489	0	0.00			0
20	Goran Pandev G. Pandev	493	28,227	321	101	0.20	27	128	2
21	Andrea Pirlo A. Pirlo	493	37,349	414	58	0.12	31	89	14
22	Tarcisio Burgnich T. Burgnich	493	44,218	493	6	0.01			0
23	Giuseppe Favalli G. Favalli	486	38,631	455	7	0.01			0
24	Alessandro Del Piero A. Del Piero	478	32,794	378	188	0.39	5	193	50
25	Angelo Peruzzi A. Peruzzi	478	41,414	475	0	0.00			0