The Cleveland Indians had the highest run differential by a team in 2017, with a differential of 254 runs.

	TEAM	DIFF	SEASON	G	W%	W	L	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Indians	254	2017	162	.630	102	60	5,511	818	1,449	333	29	212	780	604	50	1,153	88	23	6,233	2,476	574	23	45	30	125	.263	.339	.449	.788
2	Yankees	198	2017	162	.562	91	71	5,594	858	1,463	266	23	241	821	616	64	1,386	90	22	6,348	2,498	530	18	56	22	119	.262	.339	.447	.785
3	Astros	196	2017	162	.623	101	61	5,611	896	1,581	346	20	238	854	509	70	1,087	98	42	6,262	2,681	604	11	61	27	139	.282	.346	.478	.823
4	Dodgers	190	2017	162	.642	104	58	5,408	770	1,347	312	20	221	730	649	64	1,380	77	28	6,190	2,362	553	31	38	41	119	.249	.334	.437	.771
5	Diamondbacks	153	2017	162	.574	93	69	5,525	812	1,405	314	39	220	776	578	54	1,456	103	30	6,223	2,457	573	39	27	44	106	.254	.329	.445	.774
6	Nationals	147	2017	162	.599	97	65	5,553	819	1,477	311	31	215	796	542	31	1,327	108	30	6,214	2,495	557	43	45	56	116	.266	.332	.449	.782
7	Cubs	127	2017	162	.568	92	70	5,496	822	1,402	274	29	223	785	622	82	1,401	62	31	6,280	2,403	526	48	32	54	134	.255	.338	.437	.775
8	Red Sox	117	2017	162	.574	93	69	5,669	785	1,461	302	19	168	735	571	53	1,224	106	31	6,338	2,305	489	9	36	48	141	.258	.329	.407	.736
9	Rockies	67	2017	162	.537	87	75	5,534	824	1,510	293	38	192	793	519	44	1,408	59	34	6,200	2,455	523	62	41	46	143	.273	.338	.444	.781
10	Cardinals	56	2017	162	.512	83	79	5,470	761	1,402	284	28	196	728	593	65	1,348	81	31	6,219	2,330	508	47	44	36	139	.256	.334	.426	.760
11	Brewers	35	2017	162	.531	86	76	5,467	732	1,363	267	22	224	695	547	53	1,571	128	41	6,135	2,346	513	42	26	34	116	.249	.322	.429	.751
12	Twins	27	2017	162	.525	85	77	5,557	815	1,444	286	31	206	781	593	46	1,342	95	28	6,261	2,410	523	26	39	26	105	.260	.334	.434	.768
13	Angels	1	2017	162	.494	80	82	5,415	710	1,314	251	14	186	678	523	70	1,198	136	44	6,071	2,151	451	17	46	30	141	.243	.315	.397	.712
14	Rays	-10	2017	162	.494	80	82	5,478	694	1,340	226	32	228	671	545	55	1,538	88	34	6,142	2,314	486	16	48	33	115	.245	.317	.422	.739
15	Rangers	-17	2017	162	.481	78	84	5,430	799	1,326	255	21	237	756	544	81	1,493	113	44	6,121	2,334	513	27	39	18	110	.244	.320	.430	.750
16	Mariners	-22	2017	162	.481	78	84	5,551	750	1,436	281	17	200	714	487	78	1,267	89	35	6,165	2,351	498	14	35	31	131	.259	.325	.424	.749
17	Marlins	-44	2017	162	.475	77	85	5,602	778	1,497	271	31	194	743	486	67	1,282	91	30	6,246	2,412	496	50	41	48	119	.267	.331	.431	.761
18	Pirates	-63	2017	162	.463	75	87	5,458	668	1,331	249	36	151	635	519	88	1,213	67	36	6,135	2,105	436	42	28	39	120	.244	.318	.386	.704
19	Athletics	-87	2017	162	.463	75	87	5,464	739	1,344	305	15	234	708	565	43	1,491	57	22	6,125	2,381	554	13	40	15	129	.246	.319	.436	.755
20	Braves	-89	2017	162	.444	72	90	5,584	732	1,467	289	26	165	706	474	66	1,184	77	31	6,215	2,303	480	59	32	57	137	.263	.326	.412	.738
21	Royals	-89	2017	162	.494	80	82	5,536	702	1,436	260	24	193	660	390	45	1,166	91	31	6,025	2,323	477	17	37	19	160	.259	.311	.420	.731
22	Blue Jays	-91	2017	162	.469	76	86	5,499	693	1,320	269	5	222	661	542	51	1,327	53	24	6,152	2,265	496	25	35	12	153	.240	.312	.412	.724
23	Phillies	-92	2017	162	.407	66	96	5,535	690	1,382	287	36	174	654	494	47	1,417	59	25	6,133	2,263	497	21	36	25	128	.250	.315	.409	.723
24	Orioles	-98	2017	162	.463	75	87	5,650	743	1,469	269	12	232	713	392	50	1,412	32	13	6,139	2,458	513	10	37	12	138	.260	.312	.435	.747
25	White Sox	-114	2017	162	.414	67	95	5,513	706	1,412	256	37	186	670	401	76	1,397	71	31	6,058	2,300	479	35	33	17	124	.256	.314	.417	.731