The Baltimore Orioles had the highest run differential by a team in 1979, with a differential of 175 runs.

	TEAM	DIFF	SEASON	G	W%	W	L	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Orioles	175	1979	159	.642	102	57	5,371	757	1,401	258	24	181	717	608	31	847	99	49	6,106	2,250	463	42	54	52	143	.261	.336	.419	.755
2	Pirates	132	1979	163	.605	98	64	5,661	775	1,541	264	52	148	710	483	32	855	180	66	6,330	2,353	464	98	56	102	113	.272	.330	.416	.746
3	Red Sox	130	1979	160	.569	91	69	5,538	841	1,567	310	34	194	805	512	33	708	60	43	6,184	2,527	538	42	59	38	158	.283	.344	.456	.800
4	Expos	120	1979	160	.594	95	65	5,465	701	1,445	273	42	143	651	432	27	890	121	56	6,029	2,231	458	67	38	68	123	.264	.319	.408	.728
5	Angels	98	1979	162	.543	88	74	5,550	866	1,563	242	43	164	808	589	37	843	100	53	6,311	2,383	449	79	56	42	136	.282	.351	.429	.781
6	Reds	87	1979	161	.559	90	71	5,477	731	1,445	266	31	132	686	614	19	902	99	47	6,218	2,169	429	62	46	73	128	.264	.338	.396	.734
7	Brewers	85	1979	161	.590	95	66	5,536	807	1,552	291	41	185	766	549	20	745	100	53	6,227	2,480	517	72	50	48	130	.280	.345	.448	.793
8	Yankees	62	1979	160	.556	89	71	5,421	734	1,443	226	40	150	694	509	18	590	65	46	6,061	2,199	416	50	63	48	148	.266	.328	.406	.733
9	Rangers	52	1979	162	.512	83	79	5,562	750	1,549	252	26	140	718	461	33	607	79	51	6,193	2,273	418	78	59	49	135	.278	.334	.409	.743
10	Twins	39	1979	162	.506	82	80	5,544	764	1,544	256	46	112	714	526	31	693	66	45	6,296	2,228	414	142	53	37	116	.278	.341	.402	.743
11	Cardinals	38	1979	163	.531	86	76	5,734	731	1,594	279	63	100	685	460	27	838	116	69	6,347	2,299	442	63	63	69	116	.278	.331	.401	.732
12	Royals	35	1979	162	.525	85	77	5,653	851	1,596	286	79	116	791	528	35	675	207	76	6,349	2,388	481	57	76	56	114	.282	.343	.422	.766
13	Tigers	32	1979	161	.528	85	76	5,375	770	1,446	221	35	164	729	575	22	814	176	86	6,080	2,229	420	56	52	28	140	.269	.339	.415	.754
14	Dodgers	22	1979	162	.488	79	83	5,490	739	1,443	220	24	183	713	556	23	834	106	46	6,188	2,260	427	83	36	62	145	.263	.331	.412	.743
15	Astros	1	1979	162	.549	89	73	5,394	583	1,382	224	52	49	542	461	22	745	190	95	6,029	1,857	325	109	43	75	105	.256	.315	.344	.659
16	Cubs	-1	1979	162	.494	80	82	5,550	706	1,494	250	43	135	663	478	35	762	73	52	6,182	2,235	428	77	42	49	126	.269	.329	.403	.731
17	White Sox	-18	1979	160	.456	73	87	5,463	730	1,505	290	33	127	680	454	36	668	97	62	6,056	2,242	450	58	45	29	151	.275	.333	.410	.743
18	Phillies	-35	1979	163	.519	84	78	5,463	683	1,453	250	53	119	641	602	37	764	128	76	6,219	2,166	422	60	57	66	124	.266	.340	.396	.736
19	Indians	-45	1979	161	.503	81	80	5,376	760	1,388	206	29	138	707	657	42	786	143	90	6,205	2,066	373	70	60	31	122	.258	.340	.384	.724
20	Padres	-78	1979	161	.422	68	93	5,446	603	1,316	193	53	93	559	534	32	770	100	58	6,168	1,894	339	113	43	81	104	.242	.311	.348	.659
21	Giants	-79	1979	162	.438	71	91	5,395	672	1,328	192	36	125	616	580	20	925	140	73	6,131	1,967	353	89	47	61	100	.246	.319	.365	.684
22	Braves	-94	1979	160	.413	66	94	5,422	669	1,389	220	28	126	626	490	23	818	98	50	6,035	2,043	374	62	38	47	112	.256	.318	.377	.695
23	Mariners	-109	1979	162	.414	67	95	5,544	711	1,490	250	52	132	676	515	28	725	126	52	6,202	2,240	434	61	54	45	158	.269	.331	.404	.735
24	Mets	-113	1979	163	.389	63	99	5,591	593	1,399	255	41	74	558	498	35	817	135	79	6,230	1,958	370	66	40	53	117	.250	.313	.350	.664
25	Blue Jays	-249	1979	162	.327	53	109	5,423	613	1,362	253	34	95	562	448	36	663	75	56	6,010	1,968	382	65	38	21	131	.251	.311	.363	.673