Kyle Schwarber has crushed the most homers by a designated hitter in a season, with 56 home runs in 2025.

	NAME	HR	SEASON	TM	G	AB	R	H	2B	3B	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS	WRC	WRAA	WOBA	WRC+	BRAA
1	Kyle Schwarber K. Schwarber	56	2025	PHI	162	604	111	145	23	2	132	108	11	197	10	2	724	340	81	0	1	6	4	.240	.365	.563	.928	132	46	.391	153	45.8
2	Shohei Ohtani S. Ohtani	55	2025	LAD	158	611	146	172	25	9	102	109	3	187	20	6	725	380	89	0	2	20	9	.282	.392	.622	1.014	147	61.7	.418	173	63.1
3	Shohei Ohtani S. Ohtani	54	2024	LAD	159	636	134	197	38	7	130	81	6	162	59	4	728	411	99	0	5	10	7	.310	.390	.646	1.036	156	70.5	.431	181	70.3
4	David Ortiz D. Ortiz	54	2006	BOS	151	558	115	160	29	2	137	119	4	117	1	0	686	355	85	0	5	23	12	.287	.413	.636	1.049	142	56	.427	157	50.9
5	Jorge Soler J. Soler	48	2019	KCR	162	589	95	156	33	1	117	73	10	178	3	1	676	335	82	0	4	3	16	.265	.354	.569	.922	119	34.1	.378	136	31.1
6	Khris Davis K. Davis	48	2018	OAK	151	576	98	142	28	1	123	59	12	175	0	0	654	316	77	0	7	5	16	.247	.326	.549	.874	103	27	.365	136	28.2
7	David Ortiz D. Ortiz	47	2005	BOS	159	601	119	180	40	1	148	102	1	124	1	0	713	363	88	0	9	9	13	.300	.397	.604	1.001	140	54.5	.418	157	49.5
8	Rafael Palmeiro R. Palmeiro	47	1999	TEX	158	565	96	183	30	1	148	97	3	69	2	4	674	356	78	0	9	14	13	.324	.420	.630	1.050	144	55.8	.436	156	50.9
9	Shohei Ohtani S. Ohtani	46	2021	LAA	155	537	103	138	26	8	100	96	4	189	26	10	639	318	80	0	2	20	7	.257	.372	.592	.965	119	41.8	.393	150	39.4
10	Jose Canseco J. Canseco	46	1998	TOR	151	583	98	138	26	0	107	65	6	159	29	17	658	302	72	0	4	5	7	.237	.318	.518	.836	94	12.7	.354	110	8.9
11	Shohei Ohtani S. Ohtani	44	2023	LAA	135	497	102	151	26	8	95	91	3	143	20	6	594	325	78	0	3	21	9	.304	.412	.654	1.066	129	56.8	.433	179	56.5
12	J.D. Martinez	43	2018	BOS	150	569	111	188	37	2	130	69	4	146	6	1	649	358	82	0	7	11	19	.330	.402	.629	1.031	136	59.7	.427	171	54.9
13	Nelson Cruz N. Cruz	43	2016	SEA	155	589	96	169	27	1	105	62	9	159	2	0	667	327	71	0	7	5	15	.287	.360	.555	.915	114	35.8	.383	148	38.2
14	Frank Thomas F. Thomas	43	2000	CWS	159	582	115	191	44	0	143	112	5	94	1	3	707	364	87	0	8	18	13	.328	.436	.625	1.061	155	61.7	.441	160	57.6
15	Edwin Encarnacion E. Encarnacion	42	2016	TOR	160	601	99	158	34	0	127	87	5	138	2	0	701	318	76	0	8	3	22	.263	.357	.529	.886	114	31.9	.373	136	30.3
16	Edwin Encarnacion E. Encarnacion	42	2012	TOR	151	542	93	152	24	0	110	84	11	94	13	3	644	302	66	0	7	12	6	.280	.384	.557	.941	115	41.9	.396	150	37.9
17	Travis Hafner T. Hafner	42	2006	CLE	129	454	100	140	31	1	117	100	7	111	0	0	563	299	74	0	2	16	10	.308	.439	.659	1.097	128	57	.450	176	55.6
18	Jim Thome J. Thome	42	2006	CWS	143	490	108	141	26	0	109	107	6	147	0	0	610	293	68	0	7	12	4	.288	.416	.598	1.014	123	46.5	.421	152	41.3
19	Frank Thomas F. Thomas	42	2003	CWS	153	546	87	146	35	0	105	100	12	115	0	0	662	307	77	0	4	4	11	.267	.390	.562	.952	123	42.2	.404	147	38.9
20	Juan Gonzalez J. Gonzalez	42	1997	TEX	133	533	87	158	24	3	131	33	3	107	0	0	579	314	69	0	10	7	12	.296	.335	.589	.924	97	25.6	.385	127	20.1
21	Nelson Cruz N. Cruz	41	2019	MIN	120	454	81	141	26	0	108	56	7	131	0	1	520	290	67	0	3	8	14	.311	.392	.639	1.031	109	43.8	.417	164	42.7
22	Adam Dunn A. Dunn	41	2012	CWS	151	539	87	110	19	0	96	105	1	222	2	1	649	252	60	0	4	3	8	.204	.333	.468	.800	90	16.2	.346	115	11.4
23	David Ortiz D. Ortiz	41	2004	BOS	150	582	94	175	47	3	139	75	4	133	0	0	669	351	91	0	8	8	12	.301	.380	.603	.983	127	44	.408	147	39.9
24	Manny Ramirez M. Ramirez	41	2001	BOS	142	529	93	162	33	2	125	81	8	147	0	1	620	322	76	0	2	25	9	.306	.405	.609	1.014	123	46.1	.415	155	43.3
25	Marcell Ozuna M. Ozuna	40	2023	ATL	144	530	84	145	29	1	100	57	3	134	0	0	592	296	70	0	2	1	9	.274	.346	.558	.905	103	30.8	.381	139	28.8