Between the 1918 and 1942 seasons, the Philadelphia Phillies lost the most games by a team, with 2,386 losses.

Interpreted as:

most regular-season losses by a team from 1918 to 1942

	TEAM	L	W	L%	G	W%	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	PA	TB	XBH	SH	GIDP	AVG	OBP	SLG	OPS
1	Phillies	2,386	1,384	.633	3,790	.367	131,605	16,399	35,920	6,184	1,117	2,026	15,058	10,435	619	13,117	1,461	145,645	50,416	9,327	2,986	499	.273	.329	.383	.712
2	Braves	2,178	1,599	.577	3,799	.423	130,792	14,914	34,594	5,250	1,395	1,179	13,524	9,825	635	11,735	1,533	144,608	46,171	7,824	3,356	454	.264	.319	.353	.672
3	Browns	2,096	1,684	.554	3,815	.446	131,485	18,249	36,472	6,614	1,611	1,803	16,690	12,852	612	12,290	1,821	148,530	51,717	10,028	3,581	459	.277	.345	.393	.738
4	Red Sox	2,076	1,700	.550	3,795	.450	129,725	17,192	35,113	6,583	1,518	1,450	15,697	12,689	646	11,991	1,796	146,660	49,082	9,551	3,600	496	.271	.339	.378	.717
5	Athletics	2,018	1,754	.535	3,795	.465	130,730	18,165	36,021	6,382	1,524	2,209	16,720	12,492	661	13,383	1,504	147,187	52,078	10,115	3,304	516	.276	.342	.398	.740
6	White Sox	1,995	1,779	.529	3,795	.471	130,369	17,559	35,854	6,199	1,554	1,117	15,956	12,781	694	10,949	2,449	147,767	48,512	8,870	3,923	462	.275	.343	.372	.715
7	Reds	1,900	1,890	.501	3,811	.499	130,268	16,140	35,410	5,645	1,809	1,259	14,747	10,216	741	10,625	1,924	144,907	48,450	8,713	3,682	436	.272	.328	.372	.700
8	Dodgers	1,870	1,917	.494	3,820	.506	132,234	17,104	36,227	5,978	1,657	1,588	15,661	11,087	613	11,924	1,728	147,009	50,283	9,223	3,075	440	.274	.333	.380	.713
9	Senators	1,860	1,922	.492	3,816	.508	132,910	18,591	37,408	6,333	2,018	1,107	16,892	12,828	811	10,952	2,453	150,047	51,098	9,458	3,498	424	.281	.348	.384	.733
10	Tigers	1,849	1,951	.487	3,828	.513	132,683	19,916	37,763	6,857	1,859	1,801	18,162	14,051	643	11,838	2,268	151,047	53,741	10,517	3,670	496	.285	.356	.405	.761
11	Indians	1,789	2,006	.471	3,815	.529	131,826	19,135	37,609	7,423	1,763	1,585	17,517	12,776	726	11,123	1,835	149,053	53,313	10,771	3,725	424	.285	.352	.404	.756
12	Cubs	1,733	2,068	.456	3,822	.544	131,627	18,040	36,633	6,388	1,419	1,941	16,532	11,716	745	12,636	2,097	147,819	51,682	9,748	3,731	442	.278	.341	.393	.733
13	Pirates	1,732	2,050	.458	3,807	.542	132,295	18,112	37,475	5,964	2,200	1,271	16,523	11,117	621	10,098	2,307	147,436	51,652	9,435	3,403	468	.283	.342	.390	.732
14	Cardinals	1,711	2,083	.451	3,826	.549	133,816	18,929	37,949	6,936	1,804	2,000	17,377	10,924	635	12,371	2,130	148,716	54,493	10,740	3,341	411	.284	.341	.407	.748
15	Giants	1,628	2,147	.431	3,797	.569	132,505	18,625	37,331	5,792	1,438	2,419	17,121	10,687	744	11,294	1,760	146,869	53,256	9,649	2,933	539	.282	.339	.402	.741
16	Yankees	1,448	2,335	.383	3,813	.617	132,078	21,705	37,605	6,361	1,829	3,236	20,071	15,094	710	13,540	1,889	151,073	57,332	11,426	3,191	428	.285	.361	.434	.795