Between the 2000 and 2021 seasons, the New York Yankees had the most wins by a team, with 2,011 wins.

Interpreted as:

most MLB regular-season wins by team from 2000 to 2021

	TEAM	W	L	W%	G	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Yankees	2,011	1,447	.582	3,460	118,608	17,769	31,415	5,966	450	4,651	17,024	12,748	1,406	24,717	2,120	671	134,283	52,234	11,067	555	966	681	2,817	.265	.341	.440	.781
2	Cardinals	1,932	1,527	.559	3,459	117,581	16,360	31,042	6,093	539	3,771	15,558	11,512	1,393	24,101	1,603	730	132,816	49,526	10,403	1,352	978	1,060	2,753	.264	.334	.421	.755
3	Dodgers	1,930	1,532	.557	3,462	117,515	15,670	30,270	5,865	606	3,703	14,918	11,700	1,278	24,628	1,972	782	132,619	48,456	10,174	1,248	878	977	2,662	.258	.329	.412	.742
4	Red Sox	1,908	1,553	.551	3,461	120,449	17,870	32,640	7,211	576	4,114	17,009	12,448	1,233	24,744	1,740	598	135,647	53,345	11,901	456	1,061	884	2,795	.271	.343	.443	.786
5	Braves	1,858	1,600	.537	3,459	118,045	15,919	30,686	6,137	552	3,709	15,191	11,676	1,102	25,413	1,669	699	133,035	49,054	10,398	1,335	877	1,007	2,702	.260	.330	.416	.746
6	Athletics	1,851	1,609	.535	3,460	118,155	16,159	29,884	6,200	518	3,822	15,388	12,253	1,223	24,504	1,549	531	133,053	48,586	10,540	457	965	576	2,767	.253	.327	.411	.738
7	Angels	1,825	1,637	.527	3,462	118,479	16,191	31,220	6,007	577	3,662	15,408	10,562	1,192	22,851	2,374	940	131,998	49,367	10,246	768	997	810	2,718	.264	.327	.417	.744
8	Giants	1,812	1,647	.524	3,460	118,027	15,200	30,487	6,133	780	3,301	14,457	11,079	1,047	23,811	1,578	694	132,400	48,083	10,214	1,271	976	1,186	2,749	.258	.325	.407	.732
9	Indians	1,786	1,674	.516	3,460	118,203	16,439	30,774	6,437	549	3,850	15,680	11,804	1,325	25,120	1,965	750	133,100	49,859	10,836	764	1,004	654	2,663	.260	.332	.422	.754
10	Phillies	1,747	1,714	.505	3,461	118,292	15,793	30,087	6,076	705	3,776	15,042	11,834	1,297	26,003	2,136	596	133,435	48,901	10,557	1,162	850	1,066	2,404	.254	.327	.413	.740
11	Astros	1,745	1,716	.504	3,462	117,754	15,904	30,426	6,121	569	3,922	15,158	11,220	1,299	25,072	1,979	824	132,306	49,451	10,612	1,101	932	750	2,767	.258	.327	.420	.747
12	Twins	1,737	1,726	.502	3,463	118,988	16,059	31,220	6,301	696	3,480	15,221	11,045	1,101	24,361	1,872	795	132,764	49,353	10,477	658	972	710	2,720	.262	.328	.415	.743
13	Cubs	1,729	1,731	.500	3,461	117,791	15,525	30,023	6,082	615	3,903	14,781	11,282	1,324	26,627	1,567	724	132,494	49,044	10,600	1,268	829	898	2,616	.255	.325	.416	.741
14	White Sox	1,728	1,734	.499	3,462	117,938	16,017	30,675	5,776	527	4,139	15,350	10,286	1,339	24,800	1,954	909	131,291	49,922	10,442	817	911	510	2,707	.260	.324	.423	.747
15	Blue Jays	1,722	1,739	.498	3,461	118,608	16,478	30,691	6,446	516	4,288	15,731	11,111	1,214	24,637	1,667	625	132,402	51,033	11,250	521	948	536	2,769	.259	.326	.430	.756
16	Mariners	1,712	1,750	.495	3,462	118,383	15,207	30,287	5,707	531	3,511	14,460	10,709	1,141	24,954	2,157	825	131,883	47,589	9,749	737	913	716	2,523	.256	.321	.402	.723
17	Mets	1,711	1,749	.495	3,460	117,408	15,045	29,716	5,907	582	3,556	14,345	11,346	1,265	25,055	2,061	745	132,121	47,455	10,045	1,234	868	992	2,598	.253	.323	.404	.728
18	Rangers	1,701	1,762	.491	3,463	119,143	16,996	31,382	6,256	602	4,284	16,183	10,755	1,283	25,263	2,084	776	132,864	51,694	11,142	699	984	630	2,569	.263	.329	.434	.762
19	Rays	1,694	1,766	.490	3,460	117,748	15,464	29,912	5,992	711	3,680	14,729	11,295	1,332	26,564	2,523	960	131,960	48,366	10,383	631	954	602	2,419	.254	.324	.411	.735
20	Brewers	1,689	1,773	.488	3,463	117,166	15,350	29,573	6,006	601	3,998	14,664	11,243	1,453	27,668	2,183	791	131,883	48,775	10,605	1,186	835	857	2,628	.252	.323	.416	.740
21	Nationals	1,681	1,779	.486	3,460	117,034	15,196	29,966	6,124	589	3,518	14,452	11,337	1,206	25,453	1,997	810	131,861	47,822	10,231	1,389	895	999	2,656	.256	.326	.409	.734
22	Diamondbacks	1,675	1,787	.484	3,462	118,313	15,598	30,182	6,286	860	3,620	14,885	11,462	1,087	26,118	1,866	729	132,904	49,048	10,766	1,110	932	958	2,500	.255	.324	.415	.739
23	Reds	1,640	1,822	.474	3,464	117,680	15,464	29,823	5,918	512	3,999	14,770	11,479	1,409	26,748	2,031	816	132,763	48,762	10,429	1,339	856	906	2,492	.253	.325	.414	.739
24	Padres	1,624	1,839	.469	3,463	116,893	14,435	28,882	5,593	667	3,247	13,710	11,396	1,049	26,823	2,138	790	131,351	45,550	9,507	1,108	905	793	2,496	.247	.317	.390	.707
25	Rockies	1,621	1,842	.468	3,463	118,921	17,078	32,068	6,403	912	3,862	16,248	11,181	1,044	26,134	1,990	858	133,524	51,881	11,177	1,450	928	911	2,574	.270	.335	.436	.772