Since 2000, the New York Yankees have the most wins by a team, with 2,321 wins.

Interpreted as:

most MLB regular-season wins by team from 2000 to 202q

	TEAM	W	L	W%	G	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Yankees	2,321	1,678	.580	4,001	136,671	20,369	35,766	6,758	498	5,449	19,513	14,822	1,598	29,347	2,449	772	154,808	59,867	12,705	593	1,124	777	3,229	.262	.338	.438	.776
2	Dodgers	2,273	1,731	.568	4,004	135,996	18,579	35,037	6,878	692	4,484	17,723	13,769	1,503	29,161	2,349	859	153,607	56,751	12,054	1,269	1,070	1,072	2,987	.258	.330	.417	.748
3	Cardinals	2,211	1,790	.553	4,001	136,000	18,792	35,667	7,010	597	4,394	17,888	13,280	1,625	28,407	1,926	824	153,422	57,053	12,001	1,393	1,124	1,107	3,121	.262	.333	.420	.752
4	Braves	2,177	1,820	.545	3,998	136,429	18,575	35,398	7,075	607	4,528	17,741	13,347	1,309	30,111	1,990	786	153,444	57,271	12,210	1,353	1,006	1,055	3,086	.259	.329	.420	.749
5	Red Sox	2,172	1,833	.542	4,005	139,143	20,403	37,417	8,319	645	4,716	19,434	14,102	1,464	29,581	2,102	701	156,397	61,174	13,680	491	1,197	964	3,181	.269	.340	.440	.779
6	Giants	2,083	1,918	.521	4,002	136,136	17,525	34,749	6,994	849	3,890	16,683	12,881	1,291	28,690	1,793	760	152,748	55,111	11,733	1,313	1,127	1,238	3,125	.255	.323	.405	.728
7	Guardians	2,076	1,924	.519	4,000	136,379	18,730	35,245	7,328	632	4,343	17,845	13,364	1,569	29,023	2,422	873	153,301	56,866	12,303	824	1,165	767	3,027	.258	.329	.417	.746
8	Angels	2,059	1,944	.514	4,003	136,568	18,412	35,467	6,779	655	4,327	17,529	12,147	1,434	27,872	2,680	1,056	152,084	56,537	11,761	818	1,117	875	3,077	.260	.324	.414	.738
9	Astros	2,059	1,942	.515	4,002	136,089	18,438	35,123	7,026	626	4,602	17,592	12,913	1,525	29,085	2,287	915	152,746	57,207	12,254	1,144	1,075	819	3,185	.258	.327	.420	.747
10	Phillies	2,054	1,947	.513	4,001	136,713	18,382	34,800	6,992	795	4,457	17,530	13,570	1,498	30,644	2,582	690	153,970	56,753	12,244	1,198	991	1,130	2,772	.255	.326	.415	.742
11	Athletics	2,053	1,949	.513	4,002	136,137	18,190	33,975	7,005	580	4,395	17,333	13,853	1,430	29,331	1,901	618	153,031	55,325	11,980	529	1,082	611	3,160	.250	.323	.406	.729
12	Twins	2,014	1,990	.503	4,004	137,266	18,491	35,695	7,229	768	4,125	17,542	12,780	1,390	29,123	2,090	864	153,236	56,835	12,122	691	1,109	753	3,123	.260	.327	.414	.741
13	Mets	2,010	1,992	.502	4,002	135,624	17,545	34,226	6,775	657	4,207	16,741	13,102	1,612	29,417	2,389	812	152,632	54,936	11,639	1,286	1,008	1,051	2,977	.252	.323	.405	.728
14	Mariners	2,005	1,997	.501	4,002	136,417	17,578	34,486	6,514	578	4,176	16,731	12,634	1,486	30,060	2,547	926	152,349	54,684	11,268	772	1,040	763	2,875	.253	.321	.401	.722
15	Cubs	2,004	1,998	.501	4,003	136,117	18,067	34,545	6,974	718	4,507	17,205	13,117	1,569	31,269	2,033	837	153,105	56,476	12,199	1,325	977	951	2,955	.254	.324	.415	.739
16	Blue Jays	2,004	1,998	.501	4,002	136,973	18,879	35,332	7,415	575	4,879	18,032	12,857	1,436	28,813	1,938	719	152,901	58,534	12,869	560	1,075	591	3,201	.258	.326	.427	.753
17	Brewers	1,989	2,016	.497	4,006	135,331	17,826	33,931	6,839	672	4,607	17,029	13,207	1,661	32,467	2,699	908	152,390	55,935	12,118	1,233	958	924	3,013	.251	.323	.413	.736
18	Rays	1,987	2,014	.497	4,001	135,892	17,820	34,327	6,895	778	4,249	16,971	12,966	1,575	31,316	3,032	1,106	152,159	55,525	11,922	655	1,071	637	2,746	.253	.323	.409	.731
19	Rangers	1,964	2,042	.490	4,006	137,523	19,452	35,864	7,093	660	4,948	18,530	12,445	1,457	29,868	2,438	874	153,265	59,121	12,701	727	1,113	682	2,877	.261	.326	.430	.756
20	Diamondbacks	1,949	2,055	.487	4,004	136,526	18,211	34,709	7,203	976	4,247	17,366	13,304	1,316	30,394	2,303	825	153,486	56,605	12,426	1,219	1,121	1,007	2,867	.254	.324	.415	.739
21	White Sox	1,929	2,075	.482	4,004	136,259	18,047	35,009	6,621	560	4,638	17,296	11,627	1,519	29,366	2,233	983	151,294	56,664	11,819	873	1,016	547	3,102	.257	.320	.416	.736
22	Padres	1,919	2,084	.479	4,003	135,092	16,885	33,429	6,479	724	3,847	16,050	13,250	1,240	30,917	2,485	883	151,811	52,897	11,050	1,187	1,042	857	2,892	.247	.318	.392	.710
23	Nationals	1,903	2,098	.476	4,001	135,185	17,394	34,463	7,011	661	3,997	16,540	12,816	1,443	29,472	2,475	960	151,931	54,787	11,669	1,465	1,022	1,029	3,057	.255	.324	.405	.729
24	Reds	1,889	2,116	.472	4,007	135,808	17,858	34,166	6,778	603	4,585	17,050	13,182	1,700	31,645	2,540	961	153,054	55,905	11,966	1,391	973	932	2,838	.252	.323	.412	.735
25	Tigers	1,878	2,122	.470	4,000	137,127	17,873	35,709	6,850	946	4,116	17,100	11,765	1,232	30,006	1,815	823	151,949	56,799	11,912	738	1,087	674	3,097	.260	.322	.414	.736