The Los Angeles Angels allowed their most runs in a game on September 20, 2018 and on September 30, 2000, with 21 runs.

Interpreted as:

most runs allowed in a regular-season game by angels

	TEAM	R	DATE	TM		OPP	RESULT	ERA	SO	SHO	SV	IP	H	ER	HR	BB	HBP	IBB	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	H/9
1	Angels	21	9/20/2018	LAA	@	OAK	L 3-21	15.75	7	0	0	8.0	22	14	3	7	0	0	51	0	7.88	7.88	1.00	3.38	13.7	13.7	3.63	.559	23.63	24.75
2	Angels	21	9/30/2000	ANA	vs	SEA	L 9-21	21.00	9	0	0	9.0	22	21	5	11	0	0	59	2	9.00	11.00	0.82	5.00	15.3	18.6	3.67	.500	21.00	22.00
3	Angels	20	8/27/2025	LAA	@	TEX	L 3-20	21.38	6	0	0	8.0	22	19	4	4	2	0	53	0	6.75	4.50	1.50	4.50	11.3	7.5	3.25	.486	22.50	24.75
4	Angels	20	7/8/1990	CAL	@	MIL	L 7-20	22.50	6	0	0	8.0	19	20	2	8	0	0	51	0	6.75	9.00	0.75	2.25	11.8	15.7	3.38	.486	22.50	21.38
5	Angels	18	8/19/2023	LAA	vs	TBR	L 4-18	11.00	9	0	0	9.0	19	11	3	7	1	1	55	0	9.00	7.00	1.29	3.00	16.4	12.7	2.89	.457	18.00	19.00
6	Angels	18	6/30/2005	LAA	@	TEX	L 5-18	20.25	9	0	0	8.0	15	18	8	8	0	0	47	1	10.13	9.00	1.13	9.00	19.1	17.0	2.88	.318	20.25	16.88
7	Angels	18	6/30/1999	ANA	vs	TEX	L 4-18	15.00	3	0	0	9.0	20	15	1	8	1	0	57	0	3.00	8.00	0.38	1.00	5.3	14.0	3.11	.432	18.00	20.00
8	Angels	18	8/10/1996	CAL	vs	KCR	L 3-18	18.00	1	0	0	9.0	15	18	3	8	3	0	53	0	1.00	8.00	0.13	3.00	1.9	15.1	2.56	.316	18.00	15.00
9	Angels	18	6/27/1996	CAL	vs	OAK	L 2-18	17.00	8	0	0	9.0	17	17	8	12	0	0	57	0	8.00	12.00	0.67	8.00	14.0	21.1	3.22	.310	18.00	17.00
10	Angels	18	6/17/1993	CAL	vs	TEX	L 2-18	15.00	5	0	0	9.0	18	15	3	6	1	0	52	0	5.00	6.00	0.83	3.00	9.6	11.5	2.67	.405	18.00	18.00
11	Angels	17	9/6/2025	LAA	vs	ATH	L 4-17	16.00	8	0	0	9.0	21	16	4	6	1	0	56	0	8.00	6.00	1.33	4.00	14.3	10.7	3.00	.459	17.00	21.00
12	Angels	17	5/3/2010	LAA	@	BOS	L 8-17	19.13	6	0	0	8.0	20	17	4	6	1	1	50	1	6.75	6.75	1.00	4.50	12.0	12.0	3.25	.485	19.13	22.50
13	Angels	17	5/25/2009	LAA	vs	CWS	L 3-17	17.00	8	0	0	9.0	24	17	3	4	1	0	56	0	8.00	4.00	2.00	3.00	14.3	7.1	3.11	.525	17.00	24.00
14	Angels	17	8/20/1996	CAL	@	NYY	L 6-17	12.38	7	0	0	8.0	16	11	3	7	1	0	50	2	7.88	7.88	1.00	3.38	14.0	14.0	2.88	.406	19.13	18.00
15	Angels	17	5/15/1996	CAL	@	BOS	L 6-17	14.63	3	0	0	8.0	17	13	4	4	1	0	48	2	3.38	4.50	0.75	4.50	6.3	8.3	2.63	.361	19.13	19.13
16	Angels	17	8/26/1985	CAL	vs	BAL	L 3-17	17.00	9	0	0	9.0	17	17	7	6	1	0	51	3	9.00	6.00	1.50	7.00	17.6	11.8	2.56	.357	17.00	17.00
17	Angels	17	5/31/1978	CAL	@	CWS	L 2-17	7.88	1	0	0	8.0	22	7	3	4	0	1	48	0	1.13	4.50	0.25	3.38	2.1	8.3	3.25	.475	19.13	24.75
18	Angels	17	8/31/1961	LAA	vs	KCA	L 3-17	17.00	8	0	0	9.0	19	17	4	5	0	0	50	0	8.00	5.00	1.60	4.00	16.0	10.0	2.67	.455	17.00	19.00
19	Angels	16	4/27/2024	LAA	vs	MIN	L 5-16	16.00	5	0	0	9.0	17	16	3	7	2	0	51	1	5.00	7.00	0.71	3.00	9.8	13.7	2.67	.412	16.00	17.00
20	Angels	16	5/7/2023	LAA	vs	TEX	L 8-16	13.00	9	0	0	9.0	17	13	3	5	0	0	51	0	9.00	5.00	1.80	3.00	17.6	9.8	2.44	.412	16.00	17.00
21	Angels	16	4/24/2021	LAA	@	HOU	L 2-16	16.88	7	0	0	8.0	18	15	3	5	1	1	48	4	7.88	5.63	1.40	3.38	14.6	10.4	2.88	.469	18.00	20.25
22	Angels	16	8/9/2019	LAA	@	BOS	L 4-16	13.50	6	0	0	8.0	14	12	5	4	1	0	44	1	6.75	4.50	1.50	5.63	13.6	9.1	2.25	.321	18.00	15.75
23	Angels	16	5/23/2019	LAA	vs	MIN	L 7-16	16.00	7	0	0	9.0	17	16	8	6	0	0	50	2	7.00	6.00	1.17	8.00	14.0	12.0	2.56	.310	16.00	17.00
24	Angels	16	8/14/2009	LAA	@	BAL	L 6-16	18.00	6	0	0	8.0	19	16	1	5	1	1	48	1	6.75	5.63	1.20	1.13	12.5	10.4	3.00	.514	18.00	21.38
25	Angels	16	9/26/2007	LAA	@	TEX	L 2-16	18.00	11	0	0	8.0	17	16	5	6	0	0	46	0	12.38	6.75	1.83	5.63	23.9	13.0	2.88	.500	18.00	19.13