Since 2021, Patrick Corbin has lost the most games, with 68 games.

Interpreted as:

pitcher with most regular-season losses since 2021

	NAME	L	W	L%	G	W%	GS	ERA	SO	CG	SHO	SV	IP	H	ER	R	HR	BB	HBP	GF	IBB	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	ERA-	FIP	FIP-	H/9	PRAA
1	Patrick Corbin P. Corbin	68	34	.667	137	.333	137	5.53	577	2	0	0	740.1	874	455	484	132	238	18	0	4	3,267	14	7.01	2.89	2.42	1.60	17.7	7.3	1.50	.322	5.88	133	4.96	118	10.62	-60.9
2	Mitch Keller M. Keller	53	35	.602	131	.398	129	4.42	671	2	1	0	714.1	747	351	374	78	234	50	0	2	3,105	12	8.45	2.95	2.87	0.98	21.6	7.5	1.37	.323	4.71	104	3.90	94	9.41	19.6
3	Kyle Freeland K. Freeland	49	27	.645	118	.355	118	4.81	472	0	0	0	638.0	744	341	378	98	174	24	0	2	2,776	9	6.66	2.45	2.71	1.38	17.0	6.3	1.44	.322	5.33	101	4.61	106	10.50	-16.2
4	Luis Castillo L. Castillo	47	44	.516	134	.484	134	3.49	813	0	0	0	783.2	689	304	333	92	246	26	0	6	3,251	5	9.34	2.83	3.30	1.06	25.0	7.6	1.19	.288	3.82	87	3.66	89	7.91	39
5	Aaron Nola A. Nola	46	47	.495	138	.505	138	4.09	909	4	3	0	828.1	759	376	394	118	179	25	0	2	3,389	7	9.88	1.94	5.08	1.28	26.8	5.3	1.13	.297	4.28	98	3.56	84	8.25	61.4
6	Sandy Alcantara S. Alcantara	43	33	.566	106	.434	106	3.51	609	10	2	0	682.0	584	266	294	67	179	26	0	3	2,768	17	8.04	2.36	3.40	0.88	22.0	6.5	1.12	.274	3.88	83	3.55	86	7.71	43
7	Miles Mikolas M. Mikolas	43	37	.538	122	.463	121	4.42	481	1	0	0	686.1	703	337	355	88	131	23	0	0	2,855	6	6.31	1.72	3.67	1.15	16.8	4.6	1.22	.288	4.66	108	4.10	101	9.22	-4.5
8	Nick Pivetta N. Pivetta	43	41	.512	142	.488	118	4.25	784	1	0	2	695.1	609	328	340	110	245	18	4	4	2,910	28	10.15	3.17	3.20	1.42	26.9	8.4	1.23	.285	4.40	99	4.09	99	7.88	4.9
9	Brady Singer B. Singer	43	38	.531	128	.469	125	4.33	640	1	0	0	689.2	707	332	356	83	220	41	2	1	2,963	11	8.35	2.87	2.91	1.08	21.6	7.4	1.34	.315	4.65	100	4.00	97	9.23	9.8
10	José Berríos J. Berríos	41	53	.436	142	.564	142	3.91	761	2	0	0	828.2	770	360	378	118	228	51	0	5	3,443	12	8.27	2.48	3.34	1.28	22.1	6.6	1.20	.285	4.11	96	4.19	101	8.36	-3
11	Jordan Lyles J. Lyles	41	28	.594	100	.406	93	5.23	413	4	0	0	541.2	568	315	328	103	155	21	4	0	2,310	24	6.86	2.58	2.66	1.71	17.9	6.7	1.33	.287	5.45	123	5.09	122	9.44	-54.6
12	Charlie Morton C. Morton	41	47	.466	139	.534	133	4.07	828	0	0	0	742.1	653	336	360	91	300	69	1	4	3,166	16	10.04	3.64	2.76	1.10	26.2	9.5	1.28	.299	4.36	98	4.02	99	7.92	6
13	Tyler Anderson T. Anderson	40	40	.500	132	.500	128	4.00	590	0	0	0	736.0	684	327	352	96	236	27	0	8	3,111	20	7.21	2.89	2.50	1.17	19.0	7.6	1.25	.272	4.30	96	4.32	103	8.36	-9
14	Dylan Cease D. Cease	40	50	.444	144	.556	144	3.59	987	3	3	0	791.2	643	316	348	81	319	24	0	6	3,322	47	11.22	3.63	3.09	0.92	29.7	9.6	1.22	.294	3.96	87	3.30	78	7.31	78.9
15	Kevin Gausman K. Gausman	40	57	.412	139	.588	139	3.34	904	2	1	0	809.1	728	300	330	83	206	11	0	2	3,321	15	10.05	2.29	4.39	0.92	27.2	6.2	1.15	.305	3.67	83	3.06	75	8.10	94.1
16	Kyle Hendricks K. Hendricks	39	32	.549	114	.451	109	4.84	421	1	0	0	604.0	643	325	344	92	159	27	4	6	2,589	2	6.27	2.37	2.65	1.37	16.3	6.1	1.33	.292	5.13	118	4.67	113	9.58	-36.6
17	Marcus Stroman M. Stroman	39	36	.520	118	.480	115	3.78	516	1	1	1	618.1	583	260	292	63	199	22	2	2	2,596	14	7.51	2.90	2.59	0.92	19.9	7.7	1.26	.290	4.25	93	3.90	94	8.49	19.1
18	Chris Bassitt C. Bassitt	38	60	.388	135	.612	135	3.60	758	2	2	0	790.1	728	316	339	90	236	56	0	5	3,312	18	8.63	2.69	3.21	1.02	22.9	7.1	1.22	.294	3.86	89	3.83	93	8.29	24.9
19	Chris Flexen C. Flexen	38	30	.559	136	.441	99	4.45	427	0	0	3	597.0	640	295	312	85	197	12	28	4	2,568	20	6.44	2.97	2.17	1.28	16.6	7.7	1.40	.300	4.70	108	4.63	112	9.65	-33.8
20	Cole Irvin C. Irvin	38	26	.594	115	.406	90	4.35	399	0	0	1	547.2	579	265	294	77	128	29	10	4	2,337	10	6.56	2.10	3.12	1.27	17.1	5.5	1.29	.295	4.83	111	4.39	109	9.51	-23.6
21	Logan Webb L. Webb	38	54	.413	139	.587	138	3.12	788	3	2	0	848.2	789	294	324	56	183	23	0	3	3,429	14	8.36	1.94	4.31	0.59	23.0	5.3	1.15	.308	3.44	77	2.89	73	8.37	105.4
22	Kyle Gibson K. Gibson	37	42	.468	129	.532	128	4.64	617	0	0	0	723.2	722	373	391	94	242	27	0	3	3,074	20	7.67	3.01	2.55	1.17	20.1	7.9	1.33	.300	4.86	112	4.27	103	8.98	-9.7
23	Austin Gomber A. Gomber	37	28	.569	113	.431	97	5.08	411	0	0	0	544.0	581	307	321	96	156	9	2	4	2,316	13	6.80	2.58	2.63	1.59	17.7	6.7	1.35	.295	5.31	107	4.86	111	9.61	-27.4
24	Andrew Heaney A. Heaney	37	30	.552	125	.448	109	4.31	622	0	0	0	582.0	551	279	303	98	185	40	4	1	2,499	11	9.62	2.86	3.36	1.52	24.9	7.4	1.26	.292	4.69	103	4.38	104	8.52	-9.9
25	Yusei Kikuchi Y. Kikuchi	37	35	.514	139	.486	127	4.13	742	0	0	1	678.0	642	311	340	110	253	21	4	3	2,890	23	9.85	3.36	2.93	1.46	25.7	8.8	1.32	.302	4.51	102	4.30	104	8.52	-11.2