The Baltimore Orioles had the highest run differential by a team in 1969, with a differential of 262 runs.

	TEAM	DIFF	SEASON	G	W%	W	L	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Orioles	262	1969	162	.673	109	53	5,518	779	1,465	234	29	175	722	634	43	806	82	45	6,328	2,282	438	74	59	62	138	.265	.343	.414	.756
2	Twins	172	1969	162	.599	97	65	5,677	790	1,520	246	32	163	733	599	43	906	115	70	6,424	2,319	441	65	40	78	114	.268	.340	.408	.748
3	Cubs	109	1969	163	.568	92	70	5,530	720	1,400	215	40	142	671	559	36	928	30	32	6,243	2,121	397	72	46	58	111	.253	.323	.384	.707
4	Tigers	100	1969	162	.556	90	72	5,441	701	1,316	188	29	182	649	578	30	922	35	28	6,155	2,108	399	63	43	43	113	.242	.316	.387	.703
5	Mets	91	1969	162	.617	100	62	5,427	632	1,311	184	41	109	598	527	33	1,089	66	43	6,102	1,904	334	82	33	58	105	.242	.311	.351	.662
6	Dodgers	84	1969	162	.525	85	77	5,532	645	1,405	185	52	97	584	484	21	823	80	51	6,166	1,985	334	96	33	63	110	.254	.315	.359	.673
7	Giants	77	1969	162	.556	90	72	5,474	713	1,325	187	28	136	657	711	66	1,054	71	32	6,375	1,976	351	82	42	82	121	.242	.334	.361	.695
8	Pirates	73	1969	162	.543	88	74	5,626	725	1,557	220	52	119	651	454	46	944	74	34	6,235	2,238	391	73	36	86	128	.277	.334	.398	.732
9	Athletics	62	1969	162	.543	88	74	5,614	740	1,400	210	28	148	680	617	63	953	100	39	6,403	2,110	386	74	35	66	124	.249	.329	.376	.704
10	Braves	60	1969	162	.574	93	69	5,460	691	1,411	195	22	141	640	485	32	665	59	48	6,098	2,073	358	87	34	67	130	.258	.321	.380	.700
11	Cardinals	55	1969	162	.537	87	75	5,536	595	1,403	228	44	90	561	503	23	876	87	49	6,152	1,989	362	57	33	70	112	.253	.316	.359	.676
12	Senators	50	1969	162	.531	86	76	5,447	694	1,365	171	40	148	640	630	32	900	52	40	6,196	2,060	359	51	36	65	158	.251	.330	.378	.708
13	Reds	30	1969	163	.549	89	73	5,634	798	1,558	224	42	171	750	474	46	1,042	79	56	6,301	2,379	437	100	47	63	117	.277	.335	.422	.757
14	Astros	8	1969	162	.500	81	81	5,348	676	1,284	208	40	104	618	699	41	972	101	58	6,196	1,884	352	68	40	70	109	.240	.330	.352	.683
15	Red Sox	7	1969	162	.537	87	75	5,494	743	1,381	234	37	197	701	658	32	923	41	47	6,294	2,280	468	67	43	61	125	.251	.333	.415	.748
16	Yankees	-25	1969	162	.497	80	81	5,308	562	1,247	210	44	94	521	565	14	840	119	74	5,990	1,827	348	63	40	51	105	.235	.308	.344	.652
17	White Sox	-98	1969	162	.420	68	94	5,450	625	1,346	210	27	112	585	552	49	844	54	22	6,158	1,946	349	70	37	45	119	.247	.320	.357	.677
18	Phillies	-100	1969	162	.389	63	99	5,408	645	1,304	227	35	137	593	549	26	1,130	73	49	6,080	2,012	399	61	36	60	119	.241	.312	.372	.684
19	Royals	-102	1969	163	.426	69	93	5,462	586	1,311	179	32	98	538	522	43	901	129	70	6,122	1,848	309	57	38	40	125	.240	.309	.338	.648
20	Angels	-124	1969	163	.438	71	91	5,316	528	1,221	151	29	88	480	516	32	929	54	39	5,980	1,694	268	75	41	65	105	.230	.300	.319	.618
21	Indians	-144	1969	161	.385	62	99	5,365	573	1,272	173	24	119	534	535	24	906	85	37	6,014	1,850	316	47	43	49	147	.237	.307	.345	.652
22	Pilots	-160	1969	163	.395	64	98	5,444	639	1,276	179	27	125	583	626	34	1,015	167	59	6,205	1,884	331	72	29	43	111	.234	.316	.346	.662
23	Expos	-209	1969	162	.321	52	110	5,419	582	1,300	202	33	125	542	529	38	962	52	52	6,073	1,943	360	57	30	51	132	.240	.310	.359	.669
24	Padres	-278	1969	162	.321	52	110	5,357	468	1,203	180	42	99	431	423	35	1,143	45	44	5,891	1,764	321	56	20	40	122	.225	.285	.329	.614