Since January 1, 2021, Shohei Ohtani has put up the most runs, with 541 runs.

Interpreted as:

MLB most runs by a player since 1/1/2021

	NAME	R	G	AB	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Shohei Ohtani S. Ohtani	541	723	2,714	776	136	36	220	498	417	21	800	133	34	3,167	1,644	392	0	15	81	35	.286	.383	.606	.989
2	Aaron Judge A. Judge	515	678	2,442	746	128	3	233	535	484	22	760	41	8	2,968	1,579	364	0	20	77	69	.305	.422	.647	1.068
3	Juan Soto J. Soto	511	739	2,584	710	124	9	160	442	630	14	535	52	19	3,248	1,332	293	2	18	53	78	.275	.417	.515	.933
4	Freddie Freeman F. Freeman	506	732	2,787	863	195	9	117	440	364	43	532	55	11	3,221	1,427	321	0	27	53	54	.310	.394	.512	.906
5	Marcus Semien M. Semien	495	763	3,072	775	152	14	136	415	302	19	570	73	16	3,420	1,363	302	0	27	3	37	.252	.320	.444	.764
6	Mookie Betts M. Betts	481	641	2,501	690	150	13	128	375	324	30	407	60	14	2,879	1,250	291	0	24	9	37	.276	.363	.500	.862
7	José Ramírez J. Ramírez	476	737	2,816	785	173	19	151	488	316	21	374	149	31	3,184	1,449	343	0	31	81	38	.279	.352	.515	.867
8	Kyle Schwarber K. Schwarber	475	696	2,571	599	98	5	205	470	460	30	879	26	9	3,076	1,322	308	0	15	18	26	.233	.354	.514	.868
9	Trea Turner T. Turner	474	700	2,870	844	158	16	108	367	197	25	578	134	18	3,106	1,358	282	0	14	6	58	.294	.343	.473	.816
10	Vladimir Guerrero Jr. V. Guerrero Jr.	469	753	2,903	852	166	2	155	469	352	32	494	24	11	3,303	1,487	323	0	16	37	96	.293	.374	.512	.886
11	Francisco Lindor F. Lindor	461	714	2,772	710	135	11	131	423	277	51	597	104	20	3,132	1,260	277	6	26	9	41	.256	.332	.455	.787
12	Matt Olson M. Olson	458	760	2,839	739	171	4	175	521	409	28	743	5	1	3,303	1,443	350	0	27	33	69	.260	.356	.508	.864
13	Jose Altuve J. Altuve	456	645	2,559	749	141	4	117	319	266	28	446	67	19	2,867	1,249	262	1	13	11	59	.293	.364	.488	.852
14	Paul Goldschmidt P. Goldschmidt	431	728	2,750	770	166	4	123	399	311	16	692	46	3	3,092	1,313	293	0	15	16	59	.280	.355	.477	.832
15	Rafael Devers R. Devers	430	708	2,696	743	174	7	149	465	327	33	667	17	8	3,076	1,378	330	0	20	50	67	.276	.359	.511	.870
16	Pete Alonso P. Alonso	419	746	2,774	694	135	6	183	524	312	70	693	16	4	3,184	1,390	324	0	28	36	86	.250	.338	.501	.839
17	Austin Riley A. Riley	415	690	2,682	743	150	9	143	407	232	46	754	7	3	2,986	1,340	302	0	26	8	57	.277	.342	.500	.842
18	Manny Machado M. Machado	413	712	2,736	768	148	3	139	476	265	9	557	46	10	3,038	1,339	290	0	28	29	80	.281	.343	.489	.832
19	Randy Arozarena R. Arozarena	407	716	2,651	668	149	10	106	358	305	85	786	116	45	3,060	1,155	265	0	19	9	50	.252	.346	.436	.781
20	Dansby Swanson D. Swanson	406	733	2,767	701	131	10	108	385	252	15	779	64	17	3,056	1,176	249	2	20	7	40	.253	.317	.425	.742
21	Willy Adames W. Adames	395	707	2,663	637	143	5	130	424	306	11	790	43	16	3,000	1,180	278	0	20	9	52	.239	.318	.443	.761
22	Adolis García A. García	387	722	2,755	656	140	7	138	446	206	27	851	71	21	3,017	1,224	285	0	29	4	55	.238	.295	.444	.739
23	Brandon Nimmo B. Nimmo	386	660	2,494	650	123	19	90	313	316	51	604	38	10	2,881	1,081	232	7	13	2	30	.261	.354	.433	.787
24	Christian Yelich C. Yelich	385	599	2,218	592	103	10	75	301	322	18	602	92	15	2,568	940	188	2	8	23	37	.267	.363	.424	.787
25	Bryce Harper B. Harper	384	601	2,204	636	168	3	121	357	352	20	562	52	15	2,598	1,173	292	3	19	46	58	.289	.388	.532	.921