Bill Steele has the highest K/9 in a game, with 162.00 per nine innings versus the Boston Braves on July 11, 1912.

Interpreted as:

most k/9 by a player in a regular-season game

	NAME	K/9	DATE	TM		OPP	DEC	GS	ERA	SO	CG	SHO	SV	IP	H	ER	R	HR	BB	HBP	GF	IBB	TBF	WP
1	Bill Steele B. Steele	162.00	7/11/1912	SLN	vs	BSN		1	27.00	6	0	0	0	0.1	2	1	2	0	2	0	0		6	0
2	Herm Holshouser H. Holshouser	81.00	7/27/1930	SLA	vs	BSA		0	81.00	3	0	0	0	0.1	1	3	3	0	2	0	0		4	0
3	Aroldis Chapman A. Chapman	54.00	4/15/2024	PIT	@	NYM	L	0	81.00	2	0	0	0	0.1	1	3	3	0	1	0	0	0	4	1
4	Brandon Hughes B. Hughes	54.00	8/21/2022	CHC	vs	MIL		0	27.00	2	0	0	0	0.1	1	1	1	1	0	0	0	0	3	1
5	Ryan Hendrix R. Hendrix	54.00	7/16/2021	CIN	vs	MIL		0	27.00	2	0	0	0	0.1	1	1	1	0	0	0	0	0	3	2
6	Derek Law D. Law	54.00	9/27/2019	TOR	vs	TBR		0	27.00	2	0	0	0	0.1	3	1	2	0	0	0	0	0	5	0
7	Justin Anderson J. Anderson	54.00	7/13/2019	LAA	vs	SEA		0	27.00	2	0	0	0	0.1	0	1	1	0	0	0	0	0	2	1
8	Matt Barnes M. Barnes	54.00	4/12/2019	BOS	vs	BAL		0	0.00	2	0	0	0	0.1	0	0	0	0	0	0	0	0	2	1
9	Yusmeiro Petit Y. Petit	54.00	9/3/2018	OAK	vs	NYY		0	0.00	2	0	0	0	0.1	0	0	0	0	1	0	0	0	3	0
10	Roberto Osuna R. Osuna	54.00	8/20/2017	TOR	@	CHC	L	0	81.00	2	0	0	0	0.1	2	3	3	0	0	1	1	0	6	3
11	Miguel Castro M. Castro	54.00	7/30/2017	BAL	@	TEX		0	54.00	2	0	0	0	0.1	1	2	2	1	0	0	0	0	3	1
12	Dellin Betances D. Betances	54.00	6/8/2017	NYY	vs	BOS		0	0.00	2	0	0	0	0.1	0	0	0	0	2	0	1	0	4	1
13	Aroldis Chapman A. Chapman	54.00	5/27/2016	NYY	@	TBR		0	0.00	2	0	0	0	0.1	0	0	0	0	0	0	1	0	2	0
14	Jerry Blevins J. Blevins	54.00	4/17/2016	NYM	@	CLE		0	0.00	2	0	0	0	0.1	0	0	0	0	0	0	0	0	2	1
15	Josh Zeid J. Zeid	54.00	7/5/2014	HOU	@	LAA		0	27.00	2	0	0	0	0.1	1	1	1	1	2	0	0	0	5	1
16	Michael Gonzalez M. Gonzalez	54.00	6/20/2013	MIL	@	HOU	L	0	81.00	2	0	0	0	0.1	2	3	3	1	0	0	1	0	4	1
17	Carter Capps C. Capps	54.00	4/7/2013	SEA	@	CWS		0	0.00	2	0	0	0	0.1	0	0	0	0	0	0	0	0	2	1
18	Jason Frasor J. Frasor	54.00	4/7/2011	TOR	vs	OAK	L	0	27.00	2	0	0	0	0.1	1	1	1	0	0	1	0	0	4	1
19	Carlos Villanueva C. Villanueva	54.00	5/16/2010	MIL	vs	PHI		0	0.00	2	0	0	0	0.1	0	0	0	0	0	0	0	0	2	1
20	Brent Leach B. Leach	54.00	6/1/2009	LAD	vs	ARI		0	27.00	2	0	0	0	0.1	1	1	1	0	0	0	0	0	3	2
21	Wesley Wright W. Wright	54.00	9/25/2008	HOU	vs	CIN		0	0.00	2	0	0	0	0.1	0	0	0	0	0	1	0	0	3	1
22	Jose Valverde J. Valverde	54.00	4/15/2008	HOU	@	PHI	L	0	81.00	2	0	0	0	0.1	3	3	4	2	0	1	1	0	6	0
23	Derrick Turnbow D. Turnbow	54.00	8/16/2007	MIL	vs	STL		0	108.00	2	0	0	0	0.1	1	4	5	0	3	0	0	0	6	1
24	Todd Van Poppel T. Van Poppel	54.00	9/19/2002	TEX	@	SEA		0	81.00	2	0	0	0	0.1	2	3	3	1	1	1	0	0	6	2
25	Vicente Padilla V. Padilla	54.00	9/18/2000	PHI	vs	PIT	L	0	108.00	2	0	0	0	0.1	3	4	4	0	1	0	0	1	6	1