Since 2000, the New York Yankees have the most wins by a team, with 2,350 wins.

Interpreted as:

most regular-season wins by an MLB team since 2000-

	TEAM	W	L	W%	G	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Yankees	2,350	1,715	.578	4,067	138,896	20,676	36,301	6,851	506	5,552	19,807	15,057	1,615	29,912	2,498	785	157,304	60,820	12,909	598	1,138	798	3,273	.261	.338	.438	.776
2	Dodgers	2,307	1,762	.567	4,069	138,204	18,891	35,583	6,980	699	4,577	18,027	14,003	1,526	29,724	2,383	868	156,095	57,692	12,256	1,273	1,089	1,086	3,025	.257	.330	.417	.748
3	Cardinals	2,240	1,827	.551	4,067	138,193	19,049	36,189	7,112	597	4,457	18,135	13,468	1,656	28,916	1,962	830	155,858	57,866	12,166	1,403	1,138	1,111	3,165	.262	.332	.419	.751
4	Red Sox	2,211	1,858	.543	4,069	141,319	20,742	37,973	8,463	657	4,794	19,759	14,302	1,498	30,146	2,151	717	158,830	62,132	13,914	495	1,216	972	3,223	.269	.340	.440	.779
5	Braves	2,204	1,860	.542	4,065	138,704	18,874	35,941	7,178	615	4,607	18,032	13,605	1,330	30,705	2,016	791	156,018	58,170	12,400	1,359	1,020	1,063	3,126	.259	.329	.419	.748
6	Giants	2,111	1,955	.519	4,067	138,297	17,774	35,253	7,089	864	3,948	16,922	13,096	1,324	29,244	1,819	765	155,193	55,914	11,901	1,326	1,150	1,243	3,168	.255	.323	.404	.727
7	Guardians	2,108	1,956	.519	4,064	138,493	18,981	35,717	7,429	639	4,414	18,090	13,567	1,593	29,553	2,474	887	155,673	57,666	12,482	836	1,184	782	3,060	.258	.329	.416	.745
8	Astros	2,097	1,970	.516	4,068	138,361	18,733	35,713	7,138	631	4,683	17,875	13,098	1,553	29,610	2,322	925	155,254	58,162	12,452	1,149	1,093	822	3,238	.258	.327	.420	.747
9	Angels	2,093	1,976	.514	4,069	138,793	18,723	36,001	6,869	662	4,421	17,830	12,379	1,479	28,504	2,715	1,073	154,605	57,457	11,952	822	1,132	888	3,117	.259	.324	.414	.738
10	Phillies	2,088	1,979	.513	4,067	138,933	18,676	35,349	7,105	803	4,542	17,815	13,762	1,523	31,189	2,628	701	156,428	57,686	12,450	1,207	1,003	1,138	2,810	.254	.326	.415	.741
11	Athletics	2,084	1,985	.512	4,069	138,413	18,499	34,546	7,130	589	4,492	17,634	14,059	1,452	29,943	1,939	631	155,560	56,330	12,211	537	1,099	615	3,204	.250	.323	.407	.730
12	Blue Jays	2,047	2,021	.503	4,068	139,277	19,259	35,997	7,546	582	4,971	18,397	13,073	1,465	29,225	1,961	728	155,479	59,620	13,099	575	1,089	602	3,254	.258	.326	.428	.754
13	Mariners	2,042	2,027	.502	4,069	138,704	17,882	35,050	6,602	582	4,274	17,021	12,834	1,521	30,655	2,626	939	154,900	55,638	11,458	785	1,056	779	2,920	.253	.321	.401	.722
14	Twins	2,041	2,028	.502	4,069	139,457	18,776	36,224	7,330	775	4,214	17,815	12,982	1,427	29,666	2,120	875	155,681	57,746	12,319	693	1,122	756	3,169	.260	.327	.414	.741
15	Mets	2,040	2,026	.502	4,066	137,771	17,834	34,737	6,869	661	4,303	17,024	13,312	1,642	29,947	2,440	814	155,044	55,837	11,833	1,294	1,025	1,064	3,025	.252	.323	.405	.728
16	Cubs	2,037	2,028	.501	4,066	138,246	18,341	35,063	7,065	727	4,597	17,471	13,306	1,588	31,752	2,089	848	155,462	57,373	12,389	1,327	995	954	2,979	.254	.324	.415	.739
17	Brewers	2,036	2,032	.500	4,069	137,503	18,200	34,545	6,951	680	4,686	17,383	13,419	1,692	32,949	2,758	934	154,839	56,914	12,317	1,241	984	928	3,048	.251	.323	.414	.737
18	Rays	2,018	2,050	.496	4,068	138,176	18,140	34,913	7,000	788	4,332	17,269	13,159	1,597	31,904	3,111	1,131	154,687	56,485	12,120	666	1,089	646	2,786	.253	.322	.409	.731
19	Rangers	1,998	2,073	.491	4,071	139,765	19,762	36,406	7,209	667	5,017	18,823	12,663	1,484	30,420	2,494	888	155,776	60,000	12,893	733	1,131	697	2,916	.260	.326	.429	.755
20	Diamondbacks	1,981	2,088	.487	4,069	138,711	18,527	35,250	7,305	992	4,341	17,676	13,520	1,351	30,928	2,335	843	155,963	57,562	12,638	1,235	1,146	1,013	2,915	.254	.324	.415	.739
21	Padres	1,957	2,113	.481	4,070	137,341	17,161	33,994	6,590	733	3,898	16,314	13,480	1,265	31,378	2,525	894	154,356	53,744	11,221	1,210	1,060	866	2,935	.248	.318	.391	.710
22	White Sox	1,955	2,114	.480	4,069	138,424	18,313	35,516	6,722	567	4,710	17,551	11,831	1,539	29,911	2,262	993	153,711	57,502	11,999	885	1,032	554	3,149	.257	.320	.415	.735
23	Nationals	1,926	2,140	.474	4,066	137,401	17,674	35,011	7,119	672	4,055	16,814	13,005	1,464	29,982	2,522	981	154,379	55,639	11,846	1,471	1,038	1,038	3,096	.255	.324	.405	.729
24	Reds	1,925	2,145	.473	4,072	137,979	18,148	34,700	6,874	610	4,649	17,319	13,381	1,725	32,186	2,573	968	155,474	56,741	12,133	1,396	993	939	2,884	.251	.323	.411	.734
25	Tigers	1,911	2,154	.470	4,065	139,304	18,169	36,249	6,947	963	4,208	17,389	11,945	1,257	30,575	1,846	831	154,354	57,746	12,118	739	1,109	677	3,131	.260	.322	.415	.736