InterContinental Hotels Group PLC ADR (IHG) had the highest return between 2001 and 2006 by a large-cap US stock, returning 16,461,200%.

ASSET	YEARS	% RETURN
InterContinental Hotels Group PLC ADR (IHG)	2001-2006	16,461,200%
National Grid PLC ADR (NGG)	2001-2006	1,088,619.05%
Monster Beverage (MNST)	2001-2006	6,969.77%
Clean Harbors (CLH)	2001-2006	2,617.83%
Cheniere Energy (LNG)	2001-2006	2,326.06%
NetEase (NTES)	2001-2006	2,292.2%
Sterling Construction (STRL)	2001-2006	2,291.21%
Tractor Supply (TSCO)	2001-2006	2,003.67%
ArcelorMittal SA ADR (MT)	2001-2006	1,859.48%
Grupo Cibest (CIB)	2001-2006	1,799.66%
Hologic (HOLX)	2001-2006	1,701.14%
Tenaris SA ADR (TS)	2001-2006	1,615.55%
Cameco (CCJ)	2001-2006	1,368.54%
Telkom Indonesia (Persero) Tbk PT ADR Rep 100 B (TLK)	2001-2006	1,323.97%
CME (CME)	2001-2006	1,248.04%
Axon Enterprise (AXON)	2001-2006	1,204.65%
Royal Gold (RGLD)	2001-2006	1,186.42%
Cognizant Technology Solutions Corp Class A (CTSH)	2001-2006	1,169.42%
Southern Copper (SCCO)	2001-2006	1,122.39%
Tapestry (TPR)	2001-2006	1,100.62%
Deckers Outdoor (DECK)	2001-2006	1,098.92%
Apple (AAPL)	2001-2006	1,040.57%
Vale SA ADR (VALE)	2001-2006	999.98%
Alamos Gold (AGI)	2001-2006	968.01%
Chunghwa Telecom (CHT)	2001-2006	922.26%

Large-cap stocks are treated as having a market cap of $10B+.