Enphase Energy (ENPH) had the highest return between 2018 and 2022 by a US stock in the S&P 500 (GSPC), returning 10,986.2%.

ASSET	YEARS	% RETURN
Enphase Energy (ENPH)	2018-2022	10,986.19%
Trade Desk (TTD)	2018-2022	881.18%
Moderna (MRNA)	2018-2022	716.45%
DexCom (DXCM)	2018-2022	686.12%
Axon Enterprise (AXON)	2018-2022	525.68%
Advanced Micro Devices (AMD)	2018-2022	521.59%
Tesla (TSLA)	2018-2022	492.21%
Texas Pacific Land Trust (TPL)	2018-2022	471.09%
Fortinet (FTNT)	2018-2022	458.62%
Deckers Outdoor (DECK)	2018-2022	404.44%
Chipotle Mexican Grill (CMG)	2018-2022	376.96%
Eli Lilly and (LLY)	2018-2022	376.51%
Molina Healthcare (MOH)	2018-2022	330.65%
Insulet (PODD)	2018-2022	325.79%
Lululemon Athletica (LULU)	2018-2022	314.41%
Amun Bitwise Select 10 Large Cap Crypto ETP (KEYS)	2018-2022	308.28%
Super Micro Computer (SMCI)	2018-2022	292.82%
KLA-Tencor (KLAC)	2018-2022	291.59%
Fair Isaac (FICO)	2018-2022	290.18%
Paycom Soft (PAYC)	2018-2022	285.62%
MSCI (MSCI)	2018-2022	283.07%
Cadence Design Systems (CDNS)	2018-2022	282.48%
Synopsys (SNPS)	2018-2022	271.7%
Quanta Services (PWR)	2018-2022	268.2%
Carrier Global (CARR)	2018-2022	256.43%