InterContinental Hotels Group PLC ADR (IHG) had the highest return between 1999 and 2007 by a large-cap US stock, returning 11,160,200%.

ASSET	YEARS	% RETURN
InterContinental Hotels Group PLC ADR (IHG)	1999-2007	11,160,200%
Natwest (NWG)	1999-2007	9,034,940%
National Grid PLC ADR (NGG)	1999-2007	1,604,552.94%
Deckers Outdoor (DECK)	1999-2007	7,194.16%
Monster Beverage (MNST)	1999-2007	6,502.5%
Suzano Papel e Celulose SA ADR (SUZ)	1999-2007	6,414.16%
Southern Copper (SCCO)	1999-2007	3,549.21%
Clean Harbors (CLH)	1999-2007	3,081.54%
Cognizant Technology Solutions Corp Class A (CTSH)	1999-2007	2,559.87%
Axon Enterprise (AXON)	1999-2007	2,367%
Vale SA ADR (VALE)	1999-2007	2,348.21%
Logitech International (LOGI)	1999-2007	2,342.82%
Ambev SA ADR (ABEV)	1999-2007	2,183.16%
Laboratory Corporation of America (LH)	1999-2007	2,097.41%
NVIDIA (NVDA)	1999-2007	1,844.64%
Apple (AAPL)	1999-2007	1,780.58%
Cheniere Energy (LNG)	1999-2007	1,754.58%
CME (CME)	1999-2007	1,724.84%
Gilead Sciences (GILD)	1999-2007	1,695.57%
Intuitive Surgical (ISRG)	1999-2007	1,694.53%
BlackRock (BLK)	1999-2007	1,553.83%
Suncor Energy (SU)	1999-2007	1,499.52%
Sterling Construction (STRL)	1999-2007	1,486.91%
Tenaris SA ADR (TS)	1999-2007	1,465.73%
Petroleo Brasileiro Petrobras SA ADR (PBR)	1999-2007	1,452.53%

Large-cap stocks are treated as having a market cap of $10B+.