Damian Lillard has scored his most career points per game against the Lakers, with 28.5 per game.

damian lillard highest career ppg by opponent

OPP	PPG	GP	MPG	RPG	APG	SPG	BPG	TPG	FGM	FGA	FG%	3PM	3PA	3P%	FTM	FTA	FT%	MIN	PTS	REB	AST	STL	BLK	TOV	PF	+/-
Lakers	28.5	37	36.5	4.5	7.0	1.0	0.4	2.6	9.3	20.2	46.1	3.6	9.3	38.5	6.4	7.2	88.4	1,349	1,056	165	260	36	13	95	69	+233
Warriors	28.4	36	36.9	3.5	6.2	1.1	0.3	2.2	9.2	20.9	44.0	3.8	9.3	40.8	6.3	6.9	91.1	1,328	1,023	126	223	40	11	79	75	-81
Trail Blazers	28.0	2	38.6	5.5	5.5	1.5	0.0	3.5	8.0	22.0	36.4	3.5	12.5	28.0	8.5	9.0	94.4	77	56	11	11	3	0	7	4	+21
Spurs	27.8	32	37.3	4.3	7.1	1.1	0.2	2.4	9.6	20.4	47.2	2.9	7.7	37.6	5.7	6.1	93.8	1,194	891	138	226	35	7	78	68	+170
Wizards	27.5	22	37.4	4.9	7.1	0.5	0.2	2.7	8.6	20.4	42.2	3.2	9.1	35.3	7.1	7.7	91.8	824	605	108	157	11	5	60	36	+95
Mavericks	27.3	39	36.4	4.0	6.8	0.8	0.3	3.1	8.3	18.4	45.1	3.3	8.5	39.3	7.3	7.9	92.5	1,421	1,063	155	266	33	13	122	90	+69
Jazz	27.2	39	36.4	4.5	6.3	0.8	0.4	2.4	9.3	20.0	46.6	3.3	8.5	39.0	5.3	6.1	87.3	1,421	1,061	177	245	31	17	94	69	-1
Pelicans	26.7	32	36.3	4.3	6.3	1.1	0.2	2.7	8.8	19.3	45.4	2.9	8.2	35.7	6.2	6.8	90.8	1,162	853	137	201	34	5	86	53	+106
Cavaliers	26.4	22	35.7	3.6	6.7	0.8	0.3	2.4	8.5	19.1	44.8	3.4	8.5	40.3	5.9	6.5	90.3	786	581	80	147	18	6	53	42	+61
Nets	25.9	22	36.3	4.3	7.5	0.9	0.3	2.4	8.5	18.7	45.7	3.6	9.0	39.9	5.2	5.7	91.3	798	570	95	165	19	6	52	38	+61
Suns	25.8	37	36.1	3.9	6.2	0.8	0.3	3.2	8.4	18.6	45.3	2.8	7.6	36.7	6.2	7.1	87.0	1,335	956	143	228	31	12	117	70	+145
Knicks	25.8	24	35.5	4.5	6.2	1.3	0.2	2.8	8.0	17.7	45.4	3.5	8.6	41.3	6.2	6.9	89.2	851	619	108	148	30	4	68	33	+174
Raptors	25.8	23	37.3	4.1	7.3	0.8	0.6	3.5	8.4	18.2	46.3	2.7	7.5	36.4	6.2	7.0	88.8	858	593	94	167	18	13	81	40	-42
Pistons	25.3	22	36.1	5.3	7.5	1.0	0.5	2.8	7.9	18.8	42.1	3.2	8.5	38.0	6.2	6.8	91.3	794	556	116	165	23	10	61	39	+142
Magic	25.2	21	35.9	5.0	5.7	0.9	0.2	3.0	7.8	18.4	42.1	3.0	8.8	34.2	6.7	7.4	90.4	754	530	106	119	18	5	64	27	+113
Timberwolves	25.1	37	35.5	5.0	6.8	1.0	0.3	2.6	8.2	18.4	44.4	3.1	8.6	36.5	5.6	6.6	84.5	1,315	929	184	250	37	10	95	81	+108
Rockets	25.0	36	36.8	4.6	7.1	1.1	0.1	3.3	7.8	18.2	43.1	3.1	8.1	38.4	6.3	7.1	88.2	1,325	901	164	256	38	3	120	72	+75
76ers	24.8	23	35.9	4.3	6.1	0.7	0.5	3.6	7.8	18.2	43.0	3.1	8.5	36.4	6.0	6.3	95.2	826	570	99	140	17	12	83	37	+129
Kings	24.5	34	36.5	3.8	7.8	1.1	0.4	2.8	7.5	17.7	42.6	3.2	8.6	36.7	6.2	6.9	91.0	1,240	832	130	264	37	14	96	52	+138
Nuggets	24.1	39	35.5	4.2	7.3	1.1	0.2	2.5	7.9	17.3	45.7	3.2	8.1	39.1	5.1	5.7	90.0	1,386	941	163	285	43	9	96	79	+101
Pacers	24.1	24	36.9	4.3	7.0	0.9	0.5	2.4	7.8	18.0	43.1	2.5	7.3	35.1	6.0	6.7	90.6	885	578	102	167	22	11	58	55	+171
Heat	23.9	23	36.1	2.8	6.3	0.7	0.3	3.0	7.2	16.3	43.9	3.3	8.6	37.9	6.3	7.1	87.8	829	549	64	144	16	6	68	34	+5
Thunder	23.5	38	36.3	3.9	7.2	1.2	0.3	2.6	7.4	18.0	41.0	2.9	8.5	34.6	5.8	6.5	89.4	1,378	892	147	275	47	11	98	88	+85
Hornets	23.2	24	34.9	4.4	6.9	1.3	0.3	2.9	8.1	18.0	44.9	3.4	8.8	38.4	3.7	4.5	82.2	837	557	106	165	31	7	70	42	+212
Hawks	23.2	18	36.2	4.7	6.2	1.1	0.3	2.9	7.8	18.1	43.1	3.1	8.1	38.4	4.5	4.8	94.2	651	417	85	112	20	6	53	46	+28