Kyrie Irving had the most points by a guard in a game in 2021-22, with 60 points versus the Magic on March 15, 2022.

Interpreted as:

highest scoring regular-season game by a guard in 2022

	NAME	PTS	DATE	TM		OPP	MIN	REB	AST	STL	BLK	FGM	FGA	FG%	3PM	3PA	3P%	FTM	FTA	FT%	TS%	OREB	DREB	TOV	PF	+/-
1	Kyrie Irving K. Irving	60	3/15/2022	BKN	@	ORL	35	6	4	4	1	20	31	64.5	8	12	66.7	12	13	92.3	81.7	2	4	1	3	+36
2	Trae Young T. Young	56	1/3/2022	ATL	@	POR	37	4	14	0	0	17	26	65.4	7	12	58.3	15	15	100.0	85.9	1	3	4	1	+10
3	Ja Morant J. Morant	52	2/28/2022	MEM	vs	SAS	34	7	2	0	0	22	30	73.3	4	4	100.0	4	7	57.1	78.6	1	6	4	1	+23
4	Luka Dončić L. Dončić	51	2/10/2022	DAL	vs	LAC	40	9	6	1	1	17	26	65.4	7	14	50.0	10	14	71.4	79.3	0	9	7	4	+9
5	DeMar DeRozan D. DeRozan	50	3/31/2022	CHI	vs	LAC	43	5	6	1	0	17	26	65.4	2	2	100.0	14	15	93.3	76.7	0	5	2	4	+19
6	Kyrie Irving K. Irving	50	3/8/2022	BKN	@	CHA	37	3	6	1	1	15	19	78.9	9	12	75.0	11	13	84.6	101.1	0	3	3	4	+14
7	Stephen Curry S. Curry	50	11/8/2021	GSW	vs	ATL	35	7	10	4	1	14	28	50.0	9	19	47.4	13	13	100.0	74.1	2	5	2	0	+31
8	Anthony Edwards A. Edwards	49	4/7/2022	MIN	vs	SAS	39	6	8	1	0	16	28	57.1	6	14	42.9	11	14	78.6	71.7	2	4	2	2	+18
9	Devin Booker D. Booker	49	3/24/2022	PHX	@	DEN	39	4	10	3	1	16	25	64.0	2	5	40.0	15	17	88.2	75.4	0	4	2	3	+16
10	Luka Dončić L. Dončić	49	2/17/2022	DAL	@	NOP	38	15	8	0	1	17	35	48.6	7	14	50.0	8	12	66.7	60.8	1	14	5	3	+21
11	Devin Booker D. Booker	48	1/17/2022	PHX	@	SAS	35	5	6	3	0	18	33	54.5	5	13	38.5	7	8	87.5	65.7	0	5	0	2	+3
12	Anthony Edwards A. Edwards	48	11/10/2021	MIN	@	GSW	42	6	5	2	0	16	27	59.3	7	13	53.8	9	12	75.0	74.3	2	4	6	1	-3
13	Stephen Curry S. Curry	47	3/14/2022	GSW	vs	WAS	35	6	6	1	0	16	25	64.0	7	14	50.0	8	8	100.0	82.4	0	6	2	1	+17
14	Trae Young T. Young	47	3/13/2022	ATL	vs	IND	35	3	5	2	0	13	20	65.0	7	10	70.0	14	14	100.0	89.8	0	3	4	3	+2
15	Trae Young T. Young	46	3/14/2022	ATL	vs	POR	39	6	12	1	0	15	31	48.4	5	14	35.7	11	11	100.0	64.2	2	4	3	1	+10
16	Ja Morant J. Morant	46	2/26/2022	MEM	@	CHI	36	4	3	1	0	15	28	53.6	3	4	75.0	13	15	86.7	66.5	1	3	5	2	+11
17	RJ Barrett	46	2/25/2022	NYK	vs	MIA	38	9	2	0	0	13	22	59.1	6	11	54.5	14	22	63.6	72.6	0	9	3	5	-3
18	Stephen Curry S. Curry	46	12/23/2021	GSW	vs	MEM	37	4	4	2	0	13	22	59.1	8	14	57.1	12	12	100.0	84.3	0	4	3	1	+15
19	Trae Young T. Young	45	3/22/2022	ATL	@	NYK	40	1	8	1	0	13	25	52.0	7	15	46.7	12	14	85.7	72.2	0	1	4	0	+11
20	Jordan Clarkson J. Clarkson	45	3/12/2022	UTA	vs	SAC	35	0	2	1	1	15	21	71.4	7	13	53.8	8	8	100.0	91.8	0	0	2	3	+17
21	Luka Dončić L. Dončić	45	2/12/2022	DAL	vs	LAC	39	15	8	0	0	15	33	45.5	6	13	46.2	9	13	69.2	58.1	0	15	7	2	+8
22	DeMar DeRozan D. DeRozan	45	2/6/2022	CHI	vs	PHI	41	9	7	1	0	18	30	60.0	0	2	0.0	9	11	81.8	64.6	1	8	3	3	-3
23	Stephen Curry S. Curry	45	10/21/2021	GSW	vs	LAC	38	10	1	1	1	16	25	64.0	8	13	61.5	5	5	100.0	82.7	0	10	6	2	-2
24	Josh Hart J. Hart	44	3/12/2022	POR	vs	WAS	36	8	6	4	0	15	21	71.4	6	9	66.7	8	8	100.0	89.7	0	8	3	4	+22
25	De'Aaron Fox D. Fox	44	3/5/2022	SAC	@	DAL	40	2	6	1	0	18	31	58.1	3	4	75.0	5	6	83.3	65.4	0	2	1	4	+6