LeBron James put up his most points in a game against the Pistons on November 24, 2004, with 43 points.

Interpreted as:

lebron career high points in a regular-season game vs pistons

	NAME	PTS	DATE	TM		OPP	MIN	REB	AST	STL	BLK	FGM	FGA	FG%	3PM	3PA	3P%	FTM	FTA	FT%	TS%	OREB	DREB	TOV	PF	+/-
1	LeBron James L. James	43	11/24/2004	CLE	vs	DET	38	6	5	3	1	15	22	68.2	2	3	66.7	11	12	91.7	78.8	3	3	3	3	+12
2	LeBron James L. James	41	3/7/2007	CLE	@	DET	51	7	8	3	1	17	31	54.8	1	3	33.3	6	8	75.0	59.4	2	5	4	4	+8
3	LeBron James L. James	40	3/5/2010	CLE	vs	DET	42	13	6	3	2	16	27	59.3	3	7	42.9	5	6	83.3	67.5	2	11	4	1	+12
4	LeBron James L. James	39	1/28/2011	MIA	vs	DET	44	8	9	1	2	15	25	60.0	2	4	50.0	7	10	70.0	66.3	0	8	3	1	+4
5	LeBron James L. James	37	4/17/2005	CLE	@	DET	45	11	6	0	1	12	35	34.3	2	7	28.6	11	14	78.6	44.9	3	8	1	0	-6
6	LeBron James L. James	35	12/11/2022	LAL	@	DET	37	5	5	1	0	14	24	58.3	2	6	33.3	5	5	100.0	66.8	1	4	1	1	+18
7	LeBron James L. James	35	12/28/2012	MIA	@	DET	44	6	5	6	1	15	22	68.2	2	4	50.0	3	4	75.0	73.7	1	5	3	1	-2
8	LeBron James L. James	34	11/25/2009	CLE	@	DET	39	8	7	1	0	12	24	50.0	1	4	25.0	9	11	81.8	58.9	1	7	5	2	+12
9	LeBron James L. James	33	11/28/2021	LAL	vs	DET	37	5	9	2	1	12	20	60.0	4	9	44.4	5	8	62.5	70.2	0	5	2	1	+14
10	LeBron James L. James	33	2/6/2021	LAL	vs	DET	46	5	11	4	0	13	26	50.0	3	7	42.9	4	6	66.7	57.6	0	5	7	3	+8
11	LeBron James L. James	33	2/1/2009	CLE	@	DET	39	4	8	1	1	12	25	48.0	3	8	37.5	6	11	54.5	55.3	4	0	5	3	-8
12	LeBron James L. James	32	1/27/2015	CLE	@	DET	36	6	7	1	0	11	24	45.8	0	4	0.0	10	11	90.9	55.5	0	6	4	3	0
13	LeBron James L. James	32	1/25/2012	MIA	@	DET	42	6	7	2	0	9	20	45.0	1	3	33.3	13	14	92.9	61.2	1	5	4	3	+6
14	LeBron James L. James	31	3/5/2018	CLE	vs	DET	29	7	7	1	0	11	17	64.7	5	7	71.4	4	6	66.7	78.9	2	5	3	2	+14
15	LeBron James L. James	30	11/17/2015	CLE	@	DET	40	6	3	0	0	11	21	52.4	4	7	57.1	4	5	80.0	64.7	0	6	4	3	-6
16	LeBron James L. James	30	3/19/2008	CLE	vs	DET	41	7	6	1	1	11	19	57.9	2	5	40.0	6	7	85.7	67.9	3	4	0	0	+15
17	LeBron James L. James	30	12/31/2005	CLE	vs	DET	45	7	7	4	1	11	22	50.0	2	5	40.0	6	7	85.7	59.8	1	6	5	2	+5
18	LeBron James L. James	29	3/9/2017	CLE	@	DET	39	14	10	1	0	12	22	54.5	0	6	0.0	5	8	62.5	56.8	4	10	3	1	+18
19	LeBron James L. James	29	3/22/2013	MIA	vs	DET	40	8	8	2	1	12	15	80.0	1	1	100.0	4	6	66.7	82.2	1	7	3	1	+14
20	LeBron James L. James	29	3/16/2010	CLE	@	DET	43	12	12	1	1	10	22	45.5	1	3	33.3	8	11	72.7	54.0	2	10	4	0	+13
21	LeBron James L. James	29	3/22/2005	CLE	vs	DET	43	6	6	1	0	11	24	45.8	2	7	28.6	5	8	62.5	52.7	1	5	0	1	+21
22	LeBron James L. James	28	12/23/2024	LAL	vs	DET	35	11	11	0	0	10	16	62.5	2	4	50.0	6	7	85.7	73.4	2	9	2	1	-1
23	LeBron James L. James	26	4/8/2012	MIA	vs	DET	32	4	2	0	1	12	22	54.5	1	3	33.3	1	5	20.0	53.7	3	1	1	1	+10
24	LeBron James L. James	26	12/21/2006	CLE	vs	DET	43	10	5	2	0	9	20	45.0	0	1	0.0	8	8	100.0	55.3	2	8	1	1	-20
25	LeBron James L. James	26	2/27/2006	CLE	vs	DET	47	4	6	0	1	9	22	40.9	0	3	0.0	8	10	80.0	49.2	1	3	5	0	-10