LeBron James has his most career points per game versus the Cavaliers, with 29.4 per game.

lebron james highest career ppg by opponent
CLEBOSMILPORCHIUTAOKCMIASASCHAGSWBKNLALPHIINDATLPHXTORWASNOPDALNYK29.428.828.728.628.528.228.128.128.028.027.727.727.627.527.427.327.227.227.227.026.926.6
OPPGPPPGMPGRPGAPGSPGBPGTPGFGMFGAFG%3PM3PA3P%FTMFTAFT%MINPTSREBASTSTLBLKTOVPF+/-
CavaliersCavaliers
1929.437.37.17.31.40.83.110.919.755.31.64.734.46.08.372.670955913513827155927+158
CelticsCeltics
5628.838.67.27.01.61.03.310.320.550.51.54.831.76.68.973.72,1611,6114013939055186129+279
BucksBucks
6028.738.97.47.11.50.73.610.420.251.42.15.240.15.98.173.52,3331,7234444268740216129+318
Trail BlazersTrail Blazers
3828.638.59.17.52.01.13.210.720.252.71.74.538.65.67.672.81,4631,087347284754312270+108
BullsBulls
6028.539.07.76.61.70.83.610.521.150.01.24.030.36.28.573.82,3401,70945939410350217114+267
JazzJazz
3728.238.18.17.11.70.93.310.320.051.41.44.532.16.28.573.51,4101,043300264643312366+283
ThunderThunder
3428.138.37.07.41.80.93.410.520.950.41.85.235.25.26.975.71,302956238252602911759+183
HeatHeat
4228.139.26.87.01.20.53.59.820.148.81.64.734.76.99.472.91,6481,179285296502114785+160
SpursSpurs
3828.037.67.37.61.30.53.310.721.250.41.64.635.85.07.368.21,4281,065279288482012581+26
HornetsHornets
5228.037.37.87.61.51.03.410.219.153.71.54.137.96.07.876.71,9401,4564053937950175100+551
WarriorsWarriors
3727.737.48.67.01.30.94.010.120.250.02.05.337.95.57.969.21,3851,024318260483514863+65
NetsNets
5927.737.77.37.71.60.63.810.019.052.81.23.831.56.48.674.62,2231,6324294539533227112+417
LakersLakers
3027.639.37.87.31.70.73.310.121.147.71.54.633.16.08.867.81,18082923321850219961+117
76ers76ers
5227.538.37.38.01.70.83.710.219.751.51.54.334.15.77.774.41,9941,428379415864319290+298
PacersPacers
6227.438.97.66.71.60.94.09.919.949.61.34.330.06.48.872.32,4111,69647241410155249114+333
HawksHawks
6027.338.58.07.31.80.82.89.819.051.51.74.537.56.08.074.52,3121,63548043610746169114+444
SunsSuns
3927.236.97.27.21.60.73.710.119.451.91.84.937.25.37.174.11,4381,061282281642814466+224
RaptorsRaptors
5827.238.57.27.61.20.63.09.618.851.11.34.032.36.78.876.02,2331,577418443683217691+322
WizardsWizards
5427.238.27.67.41.40.83.810.019.750.61.64.635.45.67.872.62,0611,4684113987644204108+210
PelicansPelicans
4427.038.76.78.11.80.63.710.119.851.31.84.836.55.06.676.51,7031,190295355772616476+190
MavericksMavericks
3726.937.67.87.11.50.53.69.719.250.31.74.438.35.97.677.61,390996287261552013276+168
KnicksKnicks
5626.638.07.27.21.80.83.79.619.349.81.64.734.75.87.873.32,1291,4894024051024520597+481
NuggetsNuggets
3926.337.87.48.31.10.73.710.020.249.31.34.528.85.17.369.41,4751,026289322432814676-6
KingsKings
3526.238.27.58.41.70.93.49.719.350.21.75.033.15.26.875.71,338917264294613111957+178
TimberwolvesTimberwolves
3926.137.68.17.61.51.13.29.918.752.91.84.640.04.46.172.01,4641,018317298604112576+299
MagicMagic
5925.638.47.27.41.60.73.69.118.748.91.34.231.06.08.273.32,2681,509426439934221097+285
GrizzliesGrizzlies
4225.537.37.57.91.80.73.89.518.451.71.95.037.74.56.075.21,5671,071314332763015959+232
RocketsRockets
3825.237.67.16.81.30.83.59.620.247.31.75.232.14.46.667.31,429958268257513013265-30
ClippersClippers
4024.138.17.86.81.60.83.88.518.944.81.75.232.15.57.870.11,523963312273623015089+85
PistonsPistons
6023.937.36.87.21.50.53.18.918.847.21.23.931.15.06.576.32,2411,436409432893218589+303