Wilt Chamberlain has the most games with 50+ points in a season, with 45 games in 1961-62.

Interpreted as:

most 50 or more point NBA games by a player in a season

	NAME	GP	PTS	SEASON	TM	MPG	PPG	RPG	APG	SPG	BPG	FGM	FGA	FG%	3PM	3PA	3P%	FTM	FTA	FT%	TS%	OREB	DREB	TPG	MIN	REB	AST	STL	BLK	TOV	PF	+/-
1	Wilt Chamberlain W. Chamberlain	45	2,633	1961-62	PHI	48.9	58.5	26.6	2.2			23.3	43.8	53.3				11.8	18.6	63.7	56.3				2,200	1,198	97				76
2	Wilt Chamberlain W. Chamberlain	30	1,723	1962-63	SFW	48.7	57.4	24.4				23.8	42.8	55.6				9.9	16.0	61.9	57.7				1,462	731					53
3	Kobe Bryant K. Bryant	10	541	2006-07	LAL	46.7	54.1	6.3	3.2	1.2	0.3	18.8	35.1	53.6	3.5	7.4	47.3	13.0	14.5	89.7	65.2	0.8	5.5	2.5	467	63	32	12	3	25	29	+76
4	James Harden J. Harden	9	506	2018-19	HOU	40.7	56.2	9.3	7.2	2.4	0.6	16.3	33.2	49.2	6.7	16.9	39.5	16.9	18.3	92.1	68.1	2.0	7.3	4.9	366	84	65	22	5	44	28	+113
5	Wilt Chamberlain W. Chamberlain	9	498	1964-65	TOT	50.8	55.3	26.3	2.6			23.4	44.4	52.8				8.4	18.0	46.9	52.8				457	237	23				16
6	Wilt Chamberlain W. Chamberlain	9	493	1963-64	SFW	48.1	54.8	22.3	5.3			22.4	40.4	55.5				9.9	17.8	55.6	56.7				433	201	48				21
7	Michael Jordan M. Jordan	8	442	1986-87	CHI	41.5	55.3	6.9	3.8	4.1	2.0	19.0	32.1	59.1	0.0	0.6	0.0	17.3	19.9	86.8	67.6	2.3	4.6	3.9	332	55	30	33	16	31	21
8	Wilt Chamberlain W. Chamberlain	8	456	1960-61	PHI	48.6	57.0	29.5				23.3	38.3	60.8				10.5	17.4	60.4	62.1				389	236					11
9	Damian Lillard D. Lillard	6	334	2019-20	POR	40.3	55.7	5.0	8.7	1.0	0.0	16.7	30.3	54.9	8.0	15.3	52.2	14.3	14.8	96.6	75.5	0.3	4.7	2.7	242	30	52	6	0	16	7	+67
10	Kobe Bryant K. Bryant	6	345	2005-06	LAL	41.7	57.5	7.0	3.0	2.3	0.2	19.3	35.7	54.2	5.3	11.8	45.1	13.5	15.3	88.0	67.8	1.5	5.5	2.8	250	42	18	14	1	17	15	+69
11	Rick Barry R. Barry	6	309	1966-67	SFW	45.7	51.5	9.8	4.7			18.8	39.0	48.3				13.8	15.5	89.2	56.2				274	59	28				17
12	James Harden J. Harden	5	278	2019-20	HOU	38.8	55.6	4.6	7.6	2.4	1.2	16.8	31.6	53.2	7.6	16.2	46.9	14.4	15.2	94.7	72.6	1.2	3.4	4.6	194	23	38	12	6	23	18	+84
13	Michael Jordan M. Jordan	5	259	1988-89	CHI	42.0	51.8	9.0	4.6	3.8	1.0	19.4	28.6	67.8	1.2	2.4	50.0	11.8	13.4	88.1	75.1	1.6	7.4	4.0	210	45	23	19	5	20	17
14	Kareem Abdul-Jabbar K. Abdul-Jabbar	5	262	1971-72	MIL		52.4	13.8	5.8			21.4	34.0	62.9				9.6	12.8	75.0	66.1					69	29
15	Wilt Chamberlain W. Chamberlain	5	283	1965-66	PHI	47.0	56.6	28.2	3.2			23.6	37.2	63.4				9.4	15.6	60.3	64.2				235	141	16				9
16	Elgin Baylor E. Baylor	5	269	1961-62	LAL		53.8	21.4				19.4	40.4	48.0				15.0	19.4	77.3	55.0					107					16
17	Elgin Baylor E. Baylor	5	287	1960-61	LAL		57.4	22.0				21.2						15.0	18.8	79.8						110					22
18	Wilt Chamberlain W. Chamberlain	5	276	1959-60	PHI	47.4	55.2	28.8	2.0			23.6	42.6	55.4				8.0	13.4	59.7	56.9				237	144	10				12
19	Shai Gilgeous-Alexander S. Gilgeous-Alexander	4	207	2024-25	OKC	36.6	51.8	6.0	5.3	1.8	1.0	17.3	30.8	56.1	3.3	8.0	40.6	14.0	15.3	91.8	69.1	1.8	4.3	2.3	146	24	21	7	4	9	11	+58
20	Luka Dončić L. Dončić	4	214	2022-23	DAL	40.7	53.5	10.8	8.5	2.8	0.5	18.3	28.5	64.0	4.8	9.8	48.7	12.3	16.8	73.1	74.6	1.5	9.3	3.8	163	43	34	11	2	15	13	+22
21	James Harden J. Harden	4	218	2017-18	HOU	41.6	54.5	4.8	10.3	2.5	0.5	17.0	27.5	61.8	5.5	10.5	52.4	15.0	16.8	89.6	78.1	0.5	4.3	6.5	166	19	41	10	2	26	16	+27
22	Russell Westbrook R. Westbrook	4	216	2016-17	OKC	40.0	54.0	11.3	10.0	2.3	0.3	19.0	38.8	49.0	4.0	11.5	34.8	12.0	14.5	82.8	59.8	2.3	9.0	4.5	160	45	40	9	1	18	11	+32
23	Michael Jordan M. Jordan	4	227	1992-93	CHI	44.8	56.8	7.5	5.8	2.8	1.3	22.8	40.0	56.9	2.5	4.8	52.6	8.8	10.5	83.3	63.6	3.0	4.5	2.0	179	30	23	11	5	8	15
24	Michael Jordan M. Jordan	4	213	1987-88	CHI	42.0	53.3	5.0	6.0	3.3	1.8	20.3	31.0	65.3	0.3	1.3	20.0	12.5	13.5	92.6	72.1	1.5	3.5	2.5	168	20	24	13	7	10	15
25	Pete Maravich P. Maravich	4	220	1976-77	NOJ	46.5	55.0	5.5	4.5			22.0	38.5	57.1				11.0	13.0	84.6	62.2				186	22	18				13