Wilt Chamberlain has played the most career minutes per game by a center with 45.8 minutes per game.

Interpreted as:

most mpg with a minimum of 400 games played by a center in a career

	NAME	MPG	GP	PPG	RPG	APG	SPG	BPG	FGM	FGA	FG%	3PM	3PA	3P%	FTM	FTA	FT%	TS%	OREB	DREB	TPG	MIN	PTS	REB	AST	STL	BLK	TOV	PF	+/-
1	Wilt Chamberlain W. Chamberlain	45.8	1,045	30.1	22.9	4.4			12.1	22.5	54.0				5.8	11.4	51.1	54.7				47,859	31,419	23,924	4,643				2,075
2	Bill Russell B. Russell	42.3	963	15.1	22.5	4.3			5.9	13.4	44.0				3.3	5.8	56.1	47.1				40,726	14,522	21,620	4,100				2,592
3	Dave Cowens D. Cowens	38.6	766	17.6	13.6	3.8	1.1	0.9	7.5	16.3	46.0	0.0	0.1	7.1	2.6	3.4	78.3	49.6	3.0	9.8	2.2	29,565	13,516	10,444	2,910	599	488	543	2,920
4	Nate Thurmond N. Thurmond	38.2	888	15.7	15.4	2.8	0.5	2.1	6.0	14.1	42.2				3.7	5.5	67.1	47.2	2.8	6.8		33,915	13,904	13,674	2,489	125	553		2,440
5	Walt Bellamy W. Bellamy	37.3	1,043	20.1	13.7	2.4	0.7	0.6	7.6	14.7	51.6				4.9	7.8	63.2	55.4	3.4	6.2		38,940	20,941	14,241	2,544	52	48		3,536
6	Kareem Abdul-Jabbar K. Abdul-Jabbar	36.8	1,560	24.6	11.2	3.6	0.9	2.6	10.2	18.1	55.9	0.0	0.0	5.6	4.3	6.0	72.1	59.2	2.4	7.6	2.7	57,446	38,387	17,440	5,660	1,160	3,189	2,527	4,657
7	Brad Daugherty B. Daugherty	36.5	548	19.0	9.5	3.7	0.8	0.7	7.0	13.1	53.2	0.0	0.0	14.3	5.0	6.7	74.7	59.0	2.2	7.3	2.8	20,029	10,389	5,227	2,028	422	397	1,511	1,466
8	Wes Unseld W. Unseld	36.4	984	10.8	14.0	3.9	1.1	0.6	4.4	8.7	50.9	0.0	0.0	50.0	1.9	3.0	63.3	53.7	3.5	8.4	1.9	35,832	10,624	13,769	3,822	628	367	579	2,762
9	Willis Reed W. Reed	35.7	415	18.5	12.8	2.0	0.6	1.1	7.5	15.8	47.7				3.5	4.6	75.6	52.1	2.5	4.9		14,833	7,692	5,322	810	12	21		1,452
10	Hakeem Olajuwon H. Olajuwon	35.7	1,238	21.8	11.1	2.5	1.7	3.1	8.7	17.0	51.2	0.0	0.1	20.2	4.4	6.2	71.2	55.3	3.3	7.8	3.0	44,222	26,946	13,748	3,058	2,162	3,830	3,667	4,383	+564
11	Ed Macauley E. Macauley	35.7	506	17.3	7.3	3.2			5.8	13.3	43.6				5.7	7.5	76.7	52.3				18,071	8,769	3,709	1,627				1,241
12	Neil Johnston N. Johnston	35.5	516	19.4	11.3	2.5			6.4	14.4	44.4				6.6	8.6	76.8	53.4				18,298	10,023	5,856	1,269				1,681
13	Chris Bosh C. Bosh	34.8	442	18.8	8.4	1.8	0.9	1.1	6.8	13.6	50.3	0.3	0.9	32.3	4.8	5.9	80.4	57.8	2.3	6.1	1.9	15,374	8,294	3,693	816	378	497	856	1,091	+1033
14	Shaquille O'Neal S. O'Neal	34.7	1,207	23.7	10.9	2.5	0.6	2.3	9.4	16.1	58.2	0.0	0.0	4.5	4.9	9.3	52.7	58.6	3.5	7.4	2.7	41,918	28,596	13,099	3,026	739	2,732	3,310	4,146	+4887
15	David Robinson D. Robinson	34.7	987	21.1	10.6	2.5	1.4	3.0	7.5	14.4	51.8	0.0	0.1	25.0	6.1	8.3	73.6	58.3	3.1	7.5	2.4	34,271	20,790	10,497	2,441	1,388	2,954	2,417	2,835	+2454
16	Patrick Ewing P. Ewing	34.3	1,120	20.9	9.9	1.9	0.9	2.5	8.2	16.2	50.4	0.0	0.1	16.1	4.6	6.1	74.1	55.3	2.3	7.6	3.0	38,388	23,459	11,052	2,111	1,047	2,747	3,308	3,786	+412
17	Karl-Anthony Towns K. Towns	34.1	645	23.1	11.1	3.2	0.8	1.2	8.5	16.2	52.4	1.7	4.3	40.0	4.4	5.3	83.7	62.4	2.8	8.3	2.7	21,971	14,880	7,136	2,037	523	771	1,745	2,197	+1278
18	Moses Malone M. Malone	33.9	1,329	20.6	12.2	1.4	0.8	1.3	7.1	14.5	49.1	0.0	0.1	10.0	6.4	8.3	76.9	56.9	5.1	7.1	3.1	45,071	27,409	16,212	1,796	1,089	1,733	3,804	3,076
19	Jack Sikma J. Sikma	33.7	943	16.0	10.0	3.3	1.1	1.0	5.9	12.7	46.2	0.2	0.7	33.1	4.0	4.7	84.8	54.0	2.3	7.7	2.4	31,782	15,059	9,429	3,075	1,001	928	2,243	3,263
20	Bob McAdoo B. McAdoo	33.7	609	23.3	10.1	2.3	0.9	1.6	9.1	17.9	51.0	0.0	0.1	0.0	5.0	6.5	76.6	56.0	2.5	7.6	2.3	20,507	14,178	6,163	1,379	577	984	687	2,001
21	Bob Lanier B. Lanier	33.5	959	20.1	10.1	3.1	1.1	1.5	8.1	15.7	51.4	0.0	0.0	15.4	3.9	5.1	76.7	55.9	2.6	6.8	2.6	32,103	19,248	9,698	3,007	777	1,100	1,112	3,048
22	Jim Chones J. Chones	33.3	400	14.3	9.5	1.8	0.6	1.1	6.1	13.3	46.1				2.0	2.9	70.4	49.0	2.6	6.9	2.3	13,302	5,729	3,790	711	222	450	371	1,259
23	Joe Barry Carroll J. Barry Carroll	33.2	628	18.3	7.8	1.8	1.0	1.6	7.4	15.4	47.8	0.0	0.0	0.0	3.6	4.8	74.5	52.3	2.5	5.3	2.9	20,834	11,479	4,915	1,151	637	1,016	1,800	2,017
24	Artis Gilmore A. Gilmore	32.7	909	17.1	10.1	2.0	0.5	1.9	6.3	10.5	59.9	0.0	0.0	7.7	4.5	6.3	71.3	64.3	2.9	7.2	2.8	29,685	15,579	9,161	1,777	470	1,747	2,347	2,986
25	Yao Ming Y. Ming	32.5	486	19.0	9.2	1.6	0.4	1.9	7.0	13.3	52.4	0.0	0.0	20.0	5.1	6.1	83.3	59.6	2.5	6.7	2.7	15,818	9,247	4,494	769	189	920	1,311	1,596	+1491