David Thompson has the most points in a game versus the Pistons, with 73 points on April 9, 1978.

Interpreted as:

most points by a player scored in a regular-season game vs detroit

	NAME	PTS	DATE	TM		OPP	MIN	REB	AST	STL	BLK	FGM	FGA	FG%	3PM	3PA	3P%	FTM	FTA	FT%	TS%	OREB	DREB	TOV	PF	+/-
1	David Thompson D. Thompson	73	4/9/1978	DEN	@	DET	43	7	2	0	1	28	38	73.7				17	20	85.0	78.0	3	4	4	2
2	Michael Jordan M. Jordan	61	3/4/1987	CHI	@	DET	43	7	3	3	3	22	39	56.4	0	0		17	18	94.4	65.0	3	4	5	0
3	Giannis Antetokounmpo G. Antetokounmpo	59	11/13/2024	MIL	vs	DET	44	14	7	2	3	21	34	61.8	1	2	50.0	16	17	94.1	71.1	3	11	3	1	+7
4	Anthony Davis A. Davis	59	2/21/2016	NOP	@	DET	43	20	4	0	1	24	34	70.6	2	2	100.0	9	10	90.0	76.8	6	14	2	1	+17
5	Michael Jordan M. Jordan	59	4/3/1988	CHI	@	DET	42	4	6	2	2	21	27	77.8	0	1	0.0	17	19	89.5	83.4	2	2	1	4
6	Wilt Chamberlain W. Chamberlain	59	2/11/1964	SFW	@	DET	53	18	4			25	50	50.0				9	21	42.9	49.8				4
7	Wilt Chamberlain W. Chamberlain	58	1/24/1963	SFW		DET	43	23	4			25	36	69.4				8	11	72.7	71.0				2
8	Wilt Chamberlain W. Chamberlain	58	11/8/1961	PHI	@	DET	48	23	1			23	46	50.0				12	19	63.2	53.3				3
9	Wilt Chamberlain W. Chamberlain	58	11/4/1961	PHI	vs	DET	48	33	0			24	48	50.0				10	16	62.5	52.7				1
10	Wilt Chamberlain W. Chamberlain	58	1/25/1960	PHI		DET	47	42	4			24	41	58.5				10	13	76.9	62.1				3
11	Bob Pettit B. Pettit	57	2/18/1961	STL	@	DET	48	28				25	42	59.5				7	9	77.8	62.0				3
12	Elgin Baylor E. Baylor	57	2/16/1961	LAL	@	DET		26				23	45	51.1				11	14	78.6	55.7				5
13	Kevin McHale K. McHale	56	3/3/1985	BOS	vs	DET	41	16	4	1	3	22	28	78.6	0	0		12	13	92.3	83.0	10	6	4	3
14	Wilt Chamberlain W. Chamberlain	56	10/23/1962	SFW	vs	DET	48	29	4			23	35	65.7				10	17	58.8	65.9				0
15	Wilt Chamberlain W. Chamberlain	55	12/20/1961	PHI	@	DET	48	19	0			24	47	51.1				7	11	63.6	53.0				0
16	Elvin Hayes E. Hayes	54	11/13/1968	SDR	vs	DET	48	22				20	45	44.4				14	17	82.4	51.4				2
17	Wilt Chamberlain W. Chamberlain	54	12/12/1961	PHI		DET	48	25	5			22	42	52.4				10	14	71.4	56.1				2
18	Anthony Edwards A. Edwards	53	1/4/2025	MIN	@	DET	44	6	2	0	0	16	31	51.6	10	15	66.7	11	12	91.7	73.0	1	5	6	4	-3
19	Luka Dončić L. Dončić	53	1/30/2023	DAL	vs	DET	36	8	5	2	0	17	24	70.8	5	11	45.5	14	18	77.8	83.0	0	8	4	2	+8
20	Michael Jordan M. Jordan	53	3/7/1996	CHI	vs	DET	38	11	2	6	0	21	28	75.0	2	4	50.0	9	10	90.0	81.8	2	9	4	3
21	Wilt Chamberlain W. Chamberlain	53	10/23/1965	PHI	vs	DET	45	21	2			21	25	84.0				11	15	73.3	83.9				1
22	Wilt Chamberlain W. Chamberlain	53	11/12/1964	SFW	@	DET	48	23	2			22	46	47.8				9	22	40.9	47.6				3
23	Wilt Chamberlain W. Chamberlain	53	1/19/1962	PHI		DET	48	21	2			23	42	54.8				7	10	70.0	57.1				1
24	Ray Williams R. Williams	52	4/17/1982	NJN	@	DET	43	4	7			21	34	61.8	1	1	100.0	9	11	81.8	66.9				5
25	Wilt Chamberlain W. Chamberlain	52	2/18/1964	SFW		DET	48	32	2			20	37	54.1				12	16	75.0	59.0				3