I didn't find anything for this season, but the Houston Rockets had their highest point differential in a game in 2024-25 versus the Suns on March 30, with a 39 point differential.

Interpreted as:

rockets biggest win in a regular-season game this season

	TEAM	DIFF	DATE	TM		OPP	RESULT	MIN	PTS	REB	AST	STL	BLK	FGM	FGA	FG%	3PM	3PA	3P%	FTM	FTA	FT%	TS%	OREB	DREB	TOV	PF
1	Rockets	39	3/30/2025	HOU	@	PHX	W 148-109	240	148	45	37	14	4	56	98	57.1	18	31	58.1	18	25	72.0	67.9	13	32	9	15
2	Rockets	38	4/2/2025	HOU	vs	UTA	W 143-105	240	143	63	30	4	6	56	104	53.8	19	45	42.2	12	19	63.2	63.6	18	45	10	18
3	Rockets	37	3/14/2025	HOU	vs	DAL	W 133-96	240	133	67	27	5	6	54	105	51.4	15	31	48.4	10	12	83.3	60.3	17	50	10	13
4	Rockets	36	11/17/2024	HOU	@	CHI	W 143-107	240	143	66	34	8	9	55	105	52.4	10	34	29.4	23	32	71.9	60.0	14	52	10	18
5	Rockets	29	3/8/2025	HOU	vs	NOP	W 146-117	240	146	48	32	9	7	55	99	55.6	17	40	42.5	19	21	90.5	67.4	15	33	10	13
6	Rockets	28	11/22/2024	HOU	vs	POR	W 116-88	240	116	51	27	14	5	42	93	45.2	15	39	38.5	17	25	68.0	55.8	13	38	17	20
7	Rockets	27	11/6/2024	HOU	vs	SAS	W 127-100	240	127	45	28	10	5	54	96	56.3	10	27	37.0	9	15	60.0	61.9	11	34	11	13
8	Rockets	23	1/7/2025	HOU	@	WAS	W 135-112	240	135	49	31	15	2	50	97	51.5	15	38	39.5	20	23	87.0	63.0	19	30	10	17
9	Rockets	22	1/18/2025	HOU	@	POR	W 125-103	240	125	61	25	13	4	48	108	44.4	14	31	45.2	15	22	68.2	53.1	23	38	12	18
10	Rockets	21	11/15/2024	HOU	vs	LAC	W 125-104	240	125	48	31	11	3	46	95	48.4	19	44	43.2	14	18	77.8	60.7	9	39	12	25
11	Rockets	20	1/15/2025	HOU	@	DEN	W 128-108	240	128	40	28	14	6	49	94	52.1	17	38	44.7	13	17	76.5	63.1	14	26	8	19
12	Rockets	20	12/19/2024	HOU	vs	NOP	W 133-113	240	133	42	34	7	6	50	87	57.5	17	39	43.6	16	19	84.2	69.7	6	36	11	20
13	Rockets	20	10/25/2024	HOU	vs	MEM	W 128-108	240	128	64	20	10	4	43	98	43.9	17	43	39.5	25	36	69.4	56.2	23	41	17	32
14	Rockets	17	12/26/2024	HOU	@	NOP	W 128-111	240	128	54	19	7	9	46	97	47.4	18	47	38.3	18	23	78.3	59.7	18	36	15	14
15	Rockets	17	11/20/2024	HOU	vs	IND	W 130-113	240	130	47	25	16	2	47	102	46.1	12	36	33.3	24	33	72.7	55.8	13	34	13	21
16	Rockets	15	11/11/2024	HOU	vs	WAS	W 107-92	240	107	58	13	12	10	40	87	46.0	5	23	21.7	22	25	88.0	54.6	17	41	19	17
17	Rockets	14	4/4/2025	HOU	vs	OKC	W 125-111	240	125	48	24	10	5	45	92	48.9	13	29	44.8	22	26	84.6	60.4	14	34	13	16
18	Rockets	13	3/10/2025	HOU	vs	ORL	W 97-84	240	97	63	20	4	4	35	89	39.3	16	43	37.2	11	18	61.1	50.0	20	43	19	18
19	Rockets	13	12/23/2024	HOU	@	CHA	W 114-101	240	114	60	23	4	8	43	99	43.4	13	42	31.0	15	19	78.9	53.1	21	39	11	16
20	Rockets	12	3/6/2025	HOU	@	NOP	W 109-97	240	109	41	33	10	6	46	81	56.8	9	29	31.0	8	18	44.4	61.3	9	32	19	24
21	Rockets	12	2/26/2025	HOU	vs	SAS	W 118-106	240	118	60	22	4	5	48	102	47.1	11	38	28.9	11	14	78.6	54.5	20	40	14	14
22	Rockets	12	11/4/2024	HOU	vs	NYK	W 109-97	240	109	50	21	4	6	43	88	48.9	8	33	24.2	15	18	83.3	56.8	11	39	10	20
23	Rockets	11	3/27/2025	HOU	@	UTA	W 121-110	240	121	51	26	7	5	47	102	46.1	12	37	32.4	15	19	78.9	54.8	18	33	9	14
24	Rockets	11	1/1/2025	HOU	vs	DAL	W 110-99	240	110	35	16	17	1	42	89	47.2	8	25	32.0	18	23	78.3	55.5	4	31	12	18
25	Rockets	11	12/8/2024	HOU	@	LAC	W 117-106	240	117	50	23	4	4	40	82	48.8	15	41	36.6	22	26	84.6	62.6	12	38	15	16