49ers ats record vs afc since 2017

The San Francisco 49ers have a record of 21-22 against the spread against the AFC since 2017.

		TEAM	DATE	ATS	TM			OPP		RESULT	SPREAD	ATS DIFF	O/U	O/U DIFF	TD	1DWN	OFF	OPP OFF	3DWN%	4DWN%
1		49ers	10/8/2017	0-1	SF	+105	@	IND	-125	L 23-26	+1.5	-1.5 (N)	44	+5 (O)	2	23	402	447	28.6	100.0
2		49ers	12/10/2017	1-0	SF	+108	@	HOU	-118	W 26-16	-1.5	+8.5 (Y)	45.5	-3.5 (U)	2	20	416	311	18.2
3		49ers	12/17/2017	0-1	SF	-135	vs	TEN	+125	W 25-23	-2.5	-0.5 (N)	44.5	+3.5 (O)	1	23	414	328	50.0
4		49ers	12/24/2017	1-0	SF	+190	vs	JAX	-210	W 44-33	+4	+15 (Y)	43	+34 (O)	6	26	369	472	66.7
5		49ers	9/23/2018	0-1	SF	+225	@	KC	-245	L 27-38	+5.5	-5.5 (N)	53.5	+11.5 (O)	3	26	406	384	22.2	100.0
6		49ers	9/30/2018	1-0	SF	+370	@	LAC	-415	L 27-29	+9.5	+7.5 (Y)	46.5	+9.5 (O)	3	22	364	368	41.7
7		49ers	11/1/2018	1-0	SF	+115	vs	OAK	-125	W 34-3	+2	+33 (Y)	44	-7 (U)	4	18	405	242	41.7
8		49ers	12/9/2018	1-0	SF	+142	vs	DEN	-152	W 20-14	+3	+9 (Y)	45.5	-11.5 (U)	2	24	389	274	30.8	0.0
9		49ers	9/15/2019	1-0	SF	-110	@	CIN	-110	W 41-17	+1	+25 (Y)	46.5	+11.5 (O)	5	27	571	316	55.6
10		49ers	9/22/2019	0-1	SF	-301	vs	PIT	+242	W 24-20	-6.5	-2.5 (N)	44	0 (P)	3	26	436	239	54.5
11		49ers	10/7/2019	1-0	SF	-227	vs	CLE	+187	W 31-3	-4.5	+23.5 (Y)	48	-14 (U)	4	22	446	180	37.5	100.0
12		49ers	12/1/2019	1-0	SF	+204	@	BAL	-250	L 17-20	+5.5	+2.5 (Y)	45	-8 (U)	2	15	331	283	33.3	50.0
13		49ers	2/2/2020	0-1	SF	+104	@	KC	-125	L 20-31	+1.5	-9.5 (N)	53	-2 (U)	2	21	351	397	37.5	0.0
14		49ers	9/20/2020	1-0	SF	-325	@	NYJ	+265	W 31-13	-7	+11 (Y)	41.5	+2.5 (O)	4	17	359	277	53.8
15		49ers	10/11/2020	0-1	SF	-390	vs	MIA	+314	L 17-43	-8.5	-34.5 (N)	50.5	+9.5 (O)	2	19	259	436	20.0	0.0
16		49ers	10/25/2020	1-0	SF	+131	@	NE	-155	W 33-6	+3	+30 (Y)	44.5	-5.5 (U)	4	26	467	241	55.6
17		49ers	12/7/2020	0-1	SF	-124	vs	BUF	+105	L 24-34	-1.5	-11.5 (N)	48	+10 (O)	3	24	402	449	54.5	0.0
18		49ers	10/24/2021	0-1	SF	-176	vs	IND	+147	L 18-30	-3.5	-15.5 (N)	41.5	+6.5 (O)	2	13	280	295	9.1
19		49ers	11/21/2021	1-0	SF	-290	@	JAX	+233	W 30-10	-6.5	+13.5 (Y)	45.5	-5.5 (U)	3	25	333	200	50.0	100.0
20		49ers	12/12/2021	1-0	SF	-128	@	CIN	+106	W 26-23	-1.5	+1.5 (Y)	49	0 (P)	3	21	355	397	33.3
21		49ers	12/23/2021	0-1	SF	-175	@	TEN	+147	L 17-20	-3.5	-6.5 (N)	45.5	-8.5 (U)	2	22	389	278	37.5	50.0
22		49ers	1/2/2022	1-0	SF	-740	vs	HOU	+507	W 23-7	-13.5	+2.5 (Y)	44.5	-14.5 (U)	2	19	416	222	38.5	0.0
23		49ers	9/25/2022	0-1	SF	-123	@	DEN	+102	L 10-11	-1.5	-2.5 (N)	45	-24 (U)	1	13	267	261	10.0
24		49ers	10/23/2022	0-1	SF	-103	vs	KC	-118	L 23-44	+1	-20 (N)	49	+18 (O)	2	25	444	529	57.1
25		49ers	11/13/2022	0-1	SF	-361	vs	LAC	+284	W 22-16	-8	-2 (N)	45.5	-7.5 (U)	2	22	387	238	52.9	100.0
		Average		1.1											2.7	21.4	378.3	327.9	42.3	2.2
		Total		21-22											118	921	16,266	14,099	42.3	52.9

StatMuse has team, game-level data for spread records going back to the 1979 season.

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RUSH

1,179

McCaffrey

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REC

890

McCaffrey

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OPP PPG

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RUSH YDS/G

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PASS YDS/G

261.9

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2025 Division Standings

TEAM	W	L	T	PCT
Seahawks	13	3	0	.813
49ers	12	4	0	.750
Rams	11	4	0	.733
Cardinals	3	13	0	.188

DATE	MATCHUP			TIME (ET)
Sat 1/3	SEA	@	SF	8:00 PM

11 - 5

38

Final

42

12 - 4

Sun 28 Dec 2025

NFL 2025 Leaders

Pass Yards Leaders

4,482

Prescott

Dak Prescott

4,233

Goff

Jared Goff

4,203

Maye

Drake Maye

Rush Yards Leaders

1,606

Cook

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1,559

Taylor

Jonathan Taylor

1,469

Henry

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Rec Yards Leaders

1,709

Smith-Njigba

Jaxon Smith-Njigba

1,592

Nacua

Puka Nacua

1,420

Pickens

George Pickens

Pass TD Leaders

40

Stafford

Matthew Stafford

33

Goff

Jared Goff

30

Maye

Drake Maye

Rush TD Leaders

18

Taylor

Jonathan Taylor

16

Henry

Derrick Henry

14

Allen

Josh Allen

14

Adams

Davante Adams

11

McBride

Trey McBride

11

St. Brown

Amon-Ra St. Brown

QB Rating Leaders

112.9

Maye

Drake Maye

112.1

Stafford

Matthew Stafford

107.0

Goff

Jared Goff

22.0

Garrett

Myles Garrett

16.5

Burns

Brian Burns

14.0

Hunter

Danielle Hunter

NFL 2025 Rankings

30.5

29.4

28.9

28.4

28.3

27.9

Opp PPG Rankings

16.6

18.1

18.8

19.3

19.4

19.6

Total Yards Rankings

398.6

396.7

375.8

374.5

370.4

369.4

Rush Yards Rankings

157.8

156.4

149.4

134.2

127.1

126.7

Pass Yards Rankings

287.0

278.6

265.3

264.8

261.9

255.2

64.0

51.0

50.0

48.0

46.0

45.0

NFL Fantasy 2025

Fantasy RB Rankings

312.4

Taylor

Jonathan Taylor

308.9

McCaffrey

Christian McCaffrey

272.6

Gibbs

Jahmyr Gibbs

Fantasy WR Rankings

232.5

Smith-Njigba

Jaxon Smith-Njigba

219.3

Nacua

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198

Pickens

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Fantasy TE Rankings

183.4

McBride

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125.1

Goedert

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116

Kelce

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Fantasy K Rankings

194

Myers

Jason Myers

182.6

Aubrey

Brandon Aubrey

168

Fairbairn

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NFL 2025 Betting

Best Record ATS

11-4

11-5

11-5

11-5

11-5

10-5-1

Worst Record ATS

5-11

5-10-1

6-10

6-10

6-10

6-10

NFL 2025 Standings

AFC East	W	L	T	PCT
Patriots - y	13	3	0	.813
Bills - w	11	5	0	.688
Dolphins - e	7	9	0	.438
Jets - e	3	13	0	.188
AFC North	W	L	T	PCT
Steelers	9	7	0	.563
Ravens	8	8	0	.500
Bengals - e	6	10	0	.375
Browns - e	4	12	0	.250
AFC South	W	L	T	PCT
Jaguars - x	12	4	0	.750
Texans - x	11	5	0	.688
Colts - e	8	8	0	.500
Titans - e	3	13	0	.188
AFC West	W	L	T	PCT
Broncos - y	13	3	0	.813
Chargers - w	11	5	0	.688
Chiefs - e	6	10	0	.375
Raiders - e	2	14	0	.125

NFC East	W	L	T	PCT
Eagles - y	11	5	0	.688
Cowboys - e	7	8	1	.469
Commanders - e	4	12	0	.250
Giants - e	3	13	0	.188
NFC North	W	L	T	PCT
Bears - y	11	5	0	.688
Packers - w	9	6	1	.594
Vikings - e	8	8	0	.500
Lions - e	8	8	0	.500
NFC South	W	L	T	PCT
Panthers	8	8	0	.500
Buccaneers	7	9	0	.438
Falcons - e	6	9	0	.400
Saints - e	6	10	0	.375
NFC West	W	L	T	PCT
Seahawks - x	13	3	0	.813
49ers - x	12	4	0	.750
Rams - x	11	4	0	.733
Cardinals - e	3	13	0	.188

NFL 2025 Scores & Schedule

Scores

DATE	MATCHUP			SCORE
Sat 9/27	CAR	@	NE	13-42
Sat 9/27	LAC	@	NYG	18-21
Sat 9/27	JAX	@	SF	26-21
Sat 9/27	IND	@	LAR	20-27
Sat 9/27	CHI	@	LV	25-24

Schedule

DATE	MATCHUP			TIME (ET)
Mon 12/29	LAR	@	ATL	8:15 PM
Sat 1/3	CAR	@	TB	4:30 PM
Sat 1/3	SEA	@	SF	8:00 PM
Sun 1/4	TEN	@	JAX	1:00 PM
Sun 1/4	IND	@	HOU	1:00 PM