8 quarterbacks are tied for the most passing touchdowns in a game, with 7 touchdowns. The first three are Drew Brees on November 1, 2015, Nick Foles on November 3, 2013 and Peyton Manning on September 5, 2013.

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most passing tds from a player in a game
Interpreted as:
most passing tds from a player in a regular-season game
11/1/2015Brees11/3/2013Foles9/5/2013Manning9/28/1969Kapp10/28/1962Tittle11/19/1961Blanda10/17/1954Burk11/14/1943Luckman11/19/2018Mahomes9/30/2018Trubisky9/16/2018Mahomes11/1/2015Manning11/30/2014Fitzpatrick11/9/2014Rodgers11/2/2014Roethlisberger10/26/2014Roethlisberger10/14/2012Rodgers1/1/2012Flynn10/18/2009Brady9/13/2009Brees9/28/2008Favre10/21/2007Brady9/16/2007Palmer77777777666666666666666
NAMEDATETMOPPTDCMPATTPCTYDSAVGTD%INTINT%SCKSCKYRATE
Drew BreesDrew Brees11/1/2015NONOvsNYGNYG7395078.050510.114.024.000131.7
Nick FolesNick Foles11/3/2013PHIPHI@OAKOAK7222878.640614.525.000.011158.3
Peyton ManningPeyton Manning9/5/2013DENDENvsBALBAL7274264.346211.016.700.0317141.1
Joe KappJoe Kapp9/28/1969MINMINvsBALBAL7284365.144910.416.312.3129.7
Y.A. TittleY.A. Tittle10/28/1962NYGNYGvsWASWAS7273969.250512.917.900.0151.4
George BlandaGeorge Blanda11/19/1961HOUHOUvsNYTNYT7203262.541813.121.913.1132.8
Adrian BurkAdrian Burk10/17/1954PHIPHI@WASWAS7192770.42328.625.913.7120.7
Sid LuckmanSid Luckman11/14/1943CHBCHB@NYGNYG7213265.643313.521.913.1135.4
Patrick MahomesPatrick Mahomes11/19/2018KCKC@LARLAR6334671.747810.413.036.5330117.6
Mitchell TrubiskyMitchell Trubisky9/30/2018CHICHIvsTBTB6192673.135413.623.100.0110154.6
Patrick MahomesPatrick Mahomes9/16/2018KCKC@PITPIT6232882.132611.621.400.014154.8
Eli ManningEli Manning11/1/2015NYGNYG@NONO6304173.23508.514.600.0321138.2
Ryan FitzpatrickRyan Fitzpatrick11/30/2014HOUHOUvsTENTEN6243372.735810.818.200.000147.5
Aaron RodgersAaron Rodgers11/9/2014GBGBvsCHICHI6182766.731511.722.200.000145.8
Ben RoethlisbergerBen Roethlisberger11/2/2014PITPITvsBALBAL6253767.63409.216.200.0319136.3
Ben RoethlisbergerBen Roethlisberger10/26/2014PITPITvsINDIND6404981.652210.712.200.000150.6
Aaron RodgersAaron Rodgers10/14/2012GBGB@HOUHOU6243764.93389.116.200.0210133.8
Matt FlynnMatt Flynn1/1/2012GBGBvsDETDET6314470.548010.913.612.3311136.4
Tom BradyTom Brady10/18/2009NENEvsTENTEN6293485.338011.217.600.026152.8
Drew BreesDrew Brees9/13/2009NONOvsDETDET6263476.535810.517.612.900137.0
Brett FavreBrett Favre9/28/2008NYJNYJvsARIARI6243470.62898.517.612.925123.7
Tom BradyTom Brady10/21/2007NENE@MIAMIA6212584.035414.224.000.0110158.3
Carson PalmerCarson Palmer9/16/2007CINCIN@CLECLE6335066.04018.012.024.017113.4
Peyton ManningPeyton Manning11/25/2004INDIND@DETDET6232882.12368.421.400.000141.4
Peyton ManningPeyton Manning9/28/2003INDIND@NONO6202580.031412.624.000.019158.3
Results may be incomplete. StatMuse has complete game-level data for passing touchdowns going back to the 1950 season.