Myles Garrett had the most sacks by a defensive lineman in a game in 2021, with 4.5 sacks versus the Bears on September 26, 2021.

Interpreted as:

most defensive sacks by a defensive lineman in a regular-season game in 2021

	NAME	SCK	DATE	TM		OPP	TKL	AST	COMB	SCKY	INT	INT YDS	INT TD	FF	FR	FR TD
1	Myles Garrett M. Garrett	4.5	9/26/2021	CLE	vs	CHI	6	1	7	24.5	0	0	0	0	0	0
2	Cameron Jordan C. Jordan	3.5	1/2/2022	NO	vs	CAR	6	2	8	21.5	0	0	0	0	0	0
3	Chris Jones C. Jones	3.5	11/21/2021	KC	vs	DAL	4	1	5	20	0	0	0	1	1	0
4	D.J. Wonnum	3.0	12/20/2021	MIN	@	CHI	7	1	8	30	0	0	0	1	0	0
5	Aaron Donald A. Donald	3.0	12/13/2021	LAR	@	ARI	3	2	5	35	0	0	0	0	0	0
6	Jeffery Simmons J. Simmons	3.0	11/7/2021	TEN	@	LAR	3	3	6	26	0	0	0	0	0	0
7	Maxx Crosby M. Crosby	3.0	10/17/2021	LV	@	DEN	2	4	6	15.5	0	0	0	0	0	0
8	Danielle Hunter D. Hunter	3.0	9/19/2021	MIN	@	ARI	5	2	7	29	0	0	0	0	0	0
9	Arik Armstead A. Armstead	2.5	1/9/2022	SF	@	LAR	4	3	7	17	0	0	0	0	0	0
10	William Gholston W. Gholston	2.5	12/26/2021	TB	@	CAR	2	1	3	15.5	0	0	0	0	0	0
11	Yetur Gross-Matos Y. Gross-Matos	2.5	12/19/2021	CAR	@	BUF	2	3	5	11.5	0	0	0	1	0	0
12	Chris Wormley C. Wormley	2.5	12/5/2021	PIT	vs	BAL	3	2	5	19	0	0	0	0	0	0
13	Emmanuel Ogbah E. Ogbah	2.5	11/7/2021	MIA	vs	HOU	2	2	4	21.5	0	0	0	0	0	0
14	Sam Hubbard S. Hubbard	2.5	10/24/2021	CIN	@	BAL	3	2	5	5.5	0	0	0	0	0	0
15	Kenny Willekes K. Willekes	2.0	1/9/2022	MIN	vs	CHI	2	1	3	15	0	0	0	0	0	0
16	D.J. Wonnum	2.0	1/9/2022	MIN	vs	CHI	5	2	7	20	0	0	0	0	0	0
17	Jadeveon Clowney J. Clowney	2.0	1/9/2022	CLE	vs	CIN	2	0	2	20	0	0	0	1	0	0
18	Josh Hines-Allen J. Hines-Allen	2.0	1/9/2022	JAX	vs	IND	3	1	4	18	0	0	0	0	0	0
19	Mario Addison M. Addison	2.0	1/9/2022	BUF	vs	NYJ	4	0	4	8	0	0	0	1	0	0
20	Maxx Crosby M. Crosby	2.0	1/9/2022	LV	vs	LAC	6	1	7	18	0	0	0	0	0	0
21	Jadeveon Clowney J. Clowney	2.0	1/3/2022	CLE	@	PIT	4	2	6	14	0	0	0	1	0	0
22	Chris Jones C. Jones	2.0	1/2/2022	KC	@	CIN	4	0	4	17	0	0	0	0	0	0
23	Cameron Jordan C. Jordan	2.0	12/27/2021	NO	vs	MIA	4	2	6	9	0	0	0	0	0	0
24	Emmanuel Ogbah E. Ogbah	2.0	12/27/2021	MIA	@	NO	3	2	5	15.5	0	0	0	0	0	0
25	Rasheem Green R. Green	2.0	12/26/2021	SEA	vs	CHI	2	0	2	12	0	0	0	0	0	0

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Interpreted as:

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