Myles Garrett had his most sacks in a game against the Patriots on October 26, with 5 sacks.

Interpreted as:

Myles Garrett most defensive sacks regular-season game

	NAME	SCK	DATE	TM		OPP	TKL	AST	COMB	SCKY	INT	INT YDS	INT TD	FF	FR	FR TD
1	Myles Garrett M. Garrett	5.0	10/26/2025	CLE	@	NE	6	0	6	33	0	0	0	1	0	0
2	Myles Garrett M. Garrett	4.5	9/26/2021	CLE	vs	CHI	6	1	7	24.5	0	0	0	0	0	0
3	Myles Garrett M. Garrett	4.0	11/16/2025	CLE	vs	BAL	5	0	5	17	0	0	0	0	0	0
4	Myles Garrett M. Garrett	3.5	9/24/2023	CLE	vs	TEN	4	1	5	22	0	0	0	1	0	0
5	Myles Garrett M. Garrett	3.0	11/23/2025	CLE	@	LV	4	1	5	26	0	0	0	2	0	0
6	Myles Garrett M. Garrett	3.0	11/21/2024	CLE	vs	PIT	3	2	5	20	0	0	0	1	0	0
7	Myles Garrett M. Garrett	3.0	11/3/2024	CLE	vs	LAC	4	1	5	16	0	0	0	0	0	0
8	Myles Garrett M. Garrett	3.0	9/16/2019	CLE	@	NYJ	3	2	5	22	0	0	0	0	0	0
9	Myles Garrett M. Garrett	2.0	9/7/2025	CLE	vs	CIN	5	0	5	11	0	0	0	0	0	0
10	Myles Garrett M. Garrett	2.0	12/29/2024	CLE	vs	MIA	4	0	4	7	0	0	0	0	0	0
11	Myles Garrett M. Garrett	2.0	9/29/2024	CLE	@	LV	3	0	3	14	0	0	0	0	0	0
12	Myles Garrett M. Garrett	2.0	11/19/2023	CLE	vs	PIT	2	0	2	18	0	0	0	0	0	0
13	Myles Garrett M. Garrett	2.0	10/22/2023	CLE	@	IND	7	2	9	12	0	0	0	2	0	0
14	Myles Garrett M. Garrett	2.0	12/11/2022	CLE	@	CIN	4	2	6	12	0	0	0	0	0	0
15	Myles Garrett M. Garrett	2.0	10/16/2022	CLE	vs	NE	3	3	6	8	0	0	0	1	0	0
16	Myles Garrett M. Garrett	2.0	9/11/2022	CLE	@	CAR	4	0	4	11	0	0	0	1	0	0
17	Myles Garrett M. Garrett	2.0	10/25/2020	CLE	@	CIN	3	0	3	27	0	0	0	1	0	0
18	Myles Garrett M. Garrett	2.0	10/4/2020	CLE	@	DAL	2	1	3	15	0	0	0	1	0	0
19	Myles Garrett M. Garrett	2.0	9/27/2020	CLE	vs	WAS	4	0	4	10	0	0	0	1	1	0
20	Myles Garrett M. Garrett	2.0	10/13/2019	CLE	vs	SEA	3	2	5	9	0	0	0	1	0	0
21	Myles Garrett M. Garrett	2.0	9/8/2019	CLE	vs	TEN	4	1	5	13	0	0	0	0	0	0
22	Myles Garrett M. Garrett	2.0	10/21/2018	CLE	@	TB	2	0	2	12	0	0	0	1	0	0
23	Myles Garrett M. Garrett	2.0	9/20/2018	CLE	vs	NYJ	3	0	3	8	0	0	0	0	0	0
24	Myles Garrett M. Garrett	2.0	9/9/2018	CLE	vs	PIT	5	1	6	12	0	0	0	2	0	0
25	Myles Garrett M. Garrett	2.0	10/8/2017	CLE	vs	NYJ	2	0	2	12	0	0	0	0	0	0

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Myles Garrett had his most sacks in a game against the Patriots on October 26, with 5 sacks.

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