18 teams are tied for the most games in a Week-1 game with 5+ touchdowns, with 1 game. The first three are the Buffalo Bills on September 7, the Baltimore Ravens 5 times and the New Orleans Saints on September 8, 2024, on September 12, 2021 and on September 9, 2018.
| TEAM | GP | TD | DATE | TM | OPP | RESULT | PASS TD | RUSH TD | RET TD | FGM | XPM | XP2 | SFTY | PTS | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | Bills | 1 | 5 | 9/7/2025 |  BUF | vs |  BAL | W 41-40 | 2 | 3 | 0 | 3 | 2 | 0 | 0 | 41 |
| 2 |  | Ravens | 1 | 5 | 9/7/2025 | BAL | @ | BUF | L 40-41 | 2 | 3 | 0 | 2 | 4 | 0 | 0 | 40 |
| 3 |  | Saints | 1 | 5 | 9/8/2024 |  NO | vs |  CAR | W 47-10 | 3 | 2 | 0 | 4 | 5 | 0 | 0 | 47 |
| 4 |  | Packers | 1 | 5 | 9/10/2023 |  GB | @ |  CHI | W 38-20 | 3 | 1 | 1 | 1 | 5 | 0 | 0 | 38 |
| 5 |  | Cowboys | 1 | 5 | 9/10/2023 |  DAL | @ |  NYG | W 40-0 | 0 | 3 | 2 | 2 | 4 | 0 | 0 | 40 |
| 6 |  | Lions | 1 | 5 | 9/11/2022 |  DET | vs |  PHI | L 35-38 | 2 | 3 | 0 | 0 | 5 | 0 | 0 | 35 |
| 7 |  | Eagles | 1 | 5 | 9/11/2022 | PHI | @ | DET | W 38-35 | 0 | 4 | 1 | 1 | 5 | 0 | 0 | 38 |
| 8 |  | Chiefs | 1 | 6 | 9/11/2022 |  KC | @ |  ARI | W 44-21 | 5 | 1 | 0 | 1 | 5 | 0 | 0 | 44 |
| 9 |  | Cardinals | 1 | 5 | 9/12/2021 | ARI | @ |  TEN | W 38-13 | 4 | 1 | 0 | 1 | 5 | 0 | 0 | 38 |
| 10 |  | 49ers | 1 | 5 | 9/12/2021 |  SF | @ | DET | W 41-33 | 2 | 2 | 1 | 2 | 5 | 0 | 0 | 41 |
| 11 | | Saints | 1 | 5 | 9/12/2021 | NO | vs | GB | W 38-3 | 5 | 0 | 0 | 1 | 5 | 0 | 0 | 38 |
| 12 | | Ravens | 1 | 5 | 9/13/2020 | BAL | vs |  CLE | W 38-6 | 3 | 2 | 0 | 1 | 5 | 0 | 0 | 38 |
| 13 |  | Seahawks | 1 | 5 | 9/13/2020 |  SEA | @ |  ATL | W 38-25 | 4 | 1 | 0 | 1 | 5 | 0 | 0 | 38 |
| 14 | | Packers | 1 | 5 | 9/13/2020 | GB | @ |  MIN | W 43-34 | 4 | 1 | 0 | 2 | 5 | 0 | 1 | 43 |
| 15 | | Ravens | 1 | 8 | 9/8/2019 | BAL | @ |  MIA | W 59-10 | 6 | 2 | 0 | 1 | 8 | 0 | 0 | 59 |
| 16 |  | Titans | 1 | 5 | 9/8/2019 | TEN | @ | CLE | W 43-13 | 3 | 1 | 1 | 2 | 5 | 0 | 1 | 43 |
| 17 | | Cowboys | 1 | 5 | 9/8/2019 | DAL | vs | NYG | W 35-17 | 4 | 1 | 0 | 0 | 5 | 0 | 0 | 35 |
| 18 |  | Jets | 1 | 6 | 9/10/2018 |  NYJ | @ | DET | W 48-17 | 2 | 2 | 2 | 2 | 6 | 0 | 0 | 48 |
| 19 | | Saints | 1 | 5 | 9/9/2018 | NO | vs |  TB | L 40-48 | 3 | 2 | 0 | 1 | 3 | 2 | 0 | 40 |
| 20 |  | Buccaneers | 1 | 6 | 9/9/2018 | TB | @ | NO | W 48-40 | 4 | 1 | 1 | 2 | 6 | 0 | 0 | 48 |
| 21 | | Ravens | 1 | 6 | 9/9/2018 | BAL | vs | BUF | W 47-3 | 3 | 3 | 0 | 2 | 5 | 0 | 0 | 47 |
| 22 | | Chiefs | 1 | 5 | 9/9/2018 | KC | @ |  LAC | W 38-28 | 4 | 0 | 1 | 1 | 5 | 0 | 0 | 38 |
| 23 | | Lions | 1 | 5 | 9/10/2017 | DET | vs | ARI | W 35-23 | 4 | 0 | 1 | 1 | 2 | 0 | 0 | 35 |
| 24 |  | Rams | 1 | 5 | 9/10/2017 |  LAR | vs |  IND | W 46-9 | 1 | 2 | 2 | 3 | 5 | 0 | 1 | 46 |
| 25 | | Chiefs | 1 | 6 | 9/7/2017 | KC | @ |  NE | W 42-27 | 4 | 2 | 0 | 0 | 6 | 0 | 0 | 42 |
Results may be incomplete. StatMuse has complete team, game-level data for touchdowns going back to the 1944 season.
More Bills Stats
Team Rankings
PPG
34.0
4th
OPP PPG
23.7
20th
RUSH YDS/G
163.0
1st
PASS YDS/G
262.3
6th
Jets 
NFL 2025 Leaders
NFL 2025 Rankings
NFL Fantasy 2025
NFL 2025 Betting
NFL 2025 Division Standings
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
| Eagles | 3 | 0 | 0 | 1.000 |
 Commanders | 2 | 1 | 0 | .667 |
| NFC North | W | L | T | PCT |
| Packers | 2 | 1 | 0 | .667 |
| Vikings | 2 | 1 | 0 | .667 |
| NFC South | W | L | T | PCT |
| Buccaneers | 3 | 0 | 0 | 1.000 |
| Panthers | 1 | 2 | 0 | .333 |
| NFC West | W | L | T | PCT |
| 49ers | 3 | 0 | 0 | 1.000 |
| Seahawks | 3 | 1 | 0 | .750 |
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