Sergio Agüero scored his most goals in a match in the Premier League against Newcastle on October 3, 2015, with 5 goals.
| NAME | G | DATE | CLUB | OPP | MIN | A | XG | XA | PK | FK | SH | SOT | WOOD | TCH | TCH-BOX | OFF | FOUL | YC | RC | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | S. Agüero | 5 | 10/3/2015 |  Man City | vs |  Newcastle | 66 | 0 | 0 | 0 | 8 | 5 | 1 | 36 | 0 | 1 | 0 | 0 | 0 | ||
| 2 | | S. Agüero | 4 | 2/10/2018 |  Man City | vs |  Leicester | 90 | 0 | 0 | 0 | 7 | 4 | 0 | 49 | 9 | 0 | 0 | 0 | 0 | ||
| 3 | | S. Agüero | 4 | 10/18/2014 | Man City | vs |  Tottenham | 90 | 0 | 2 | 0 | 11 | 8 | 0 | 51 | 0 | 1 | 0 | 0 | 0 | ||
| 4 | | S. Agüero | 3 | 1/12/2020 | Man City | @ |  Aston Villa | 90 | 1 | 0 | 0 | 7 | 5 | 0 | 51 | 8 | 0 | 1 | 0 | 0 | ||
| 5 | | S. Agüero | 3 | 2/10/2019 | Man City | vs |  Chelsea | 65 | 0 | 1 | 0 | 6 | 3 | 1 | 36 | 8 | 1 | 2 | 0 | 0 | ||
| 6 | | S. Agüero | 3 | 2/3/2019 | Man City | vs |  Arsenal | 81 | 0 | 0 | 0 | 4 | 4 | 0 | 42 | 8 | 3 | 1 | 0 | 0 | ||
| 7 | | S. Agüero | 3 | 8/19/2018 | Man City | vs |  Huddersfield | 76 | 0 | 0 | 0 | 9 | 4 | 1 | 48 | 11 | 1 | 0 | 0 | 0 | ||
| 8 | | S. Agüero | 3 | 1/20/2018 | Man City | vs | Newcastle | 90 | 0 | 1 | 0 | 7 | 4 | 0 | 61 | 11 | 0 | 0 | 0 | 0 | ||
| 9 | | S. Agüero | 3 | 9/16/2017 | Man City | @ |  Watford | 90 | 1 | 0 | 0 | 8 | 4 | 0 | 47 | 9 | 0 | 0 | 0 | 0 | ||
| 10 | | S. Agüero | 3 | 4/16/2016 | Man City | @ | Chelsea | 85 | 0 | 1 | 0 | 4 | 4 | 0 | 57 | 0 | 0 | 1 | 0 | 0 | ||
| 11 | | S. Agüero | 3 | 5/10/2015 | Man City | vs |  QPR | 90 | 1 | 1 | 0 | 5 | 4 | 0 | 51 | 0 | 1 | 1 | 0 | 0 | ||
| 12 | | S. Agüero | 3 | 9/10/2011 | Man City | vs |  Wigan Athletic | 72 | 0 | 0 | 0 | 0 | ||||||||||
| 13 |  | S. Agüero | 3 | 5/21/2011 |  Atlético Madrid | @ |  Mallorca | 84 | 0 | 0 | 0 | |||||||||||
| 14 | | S. Agüero | 2 | 5/23/2021 | Man City | vs |  Everton | 25 | 0 | 0 | 0 | 4 | 4 | 0 | 23 | 6 | 0 | 0 | 0 | 0 | ||
| 15 | | S. Agüero | 2 | 1/18/2020 | Man City | vs |  Crystal Palace | 90 | 0 | 0 | 0 | 6 | 3 | 0 | 37 | 17 | 0 | 1 | 0 | 0 | ||
| 16 | | S. Agüero | 2 | 8/31/2019 | Man City | vs |  Brighton | 90 | 1 | 0 | 0 | 5 | 2 | 0 | 35 | 8 | 0 | 0 | 0 | 0 | ||
| 17 | | S. Agüero | 2 | 8/25/2019 | Man City | @ |  Bournemouth | 90 | 0 | 0 | 0 | 4 | 2 | 0 | 36 | 7 | 0 | 0 | 0 | 0 | ||
| 18 | | S. Agüero | 2 | 12/23/2017 | Man City | vs | Bournemouth | 90 | 1 | 0 | 0 | 3 | 2 | 0 | 48 | 6 | 2 | 0 | 0 | 0 | ||
| 19 | | S. Agüero | 2 | 5/21/2017 | Man City | @ | Watford | 71 | 1 | 0 | 0 | 8 | 5 | 0 | 48 | 15 | 0 | 2 | 0 | 0 | ||
| 20 | | S. Agüero | 2 | 11/26/2016 | Man City | @ |  Burnley | 89 | 0 | 0 | 0 | 7 | 4 | 0 | 46 | 9 | 3 | 2 | 1 | 0 | ||
| 21 | | S. Agüero | 2 | 10/29/2016 | Man City | @ |  West Brom | 90 | 0 | 0 | 0 | 5 | 2 | 0 | 63 | 8 | 1 | 0 | 0 | 0 | ||
| 22 | | S. Agüero | 2 | 9/24/2016 | Man City | @ |  Swansea | 90 | 0 | 1 | 0 | 4 | 2 | 0 | 50 | 12 | 0 | 0 | 0 | 0 | ||
| 23 | | S. Agüero | 2 | 8/20/2016 | Man City | @ |  Stoke City | 83 | 0 | 1 | 0 | 4 | 3 | 0 | 35 | 7 | 0 | 0 | 0 | 0 | ||
| 24 | | S. Agüero | 2 | 3/5/2016 | Man City | vs |  Aston Villa | 90 | 0 | 0 | 0 | 8 | 4 | 1 | 75 | 0 | 1 | 0 | 0 | 0 | ||
| 25 | | S. Agüero | 2 | 1/23/2016 | Man City | @ |  West Ham | 90 | 0 | 1 | 0 | 7 | 3 | 1 | 56 | 0 | 1 | 1 | 0 | 0 | ||
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