Regeneron Pharmaceuticals (REGN) had the highest return between 2010 and 2012 by a US stock in the S&P 500 (GSPC), returning 605.7%.

ASSET	YEARS	% RETURN
Regeneron Pharmaceuticals (REGN)	2010-2012	605.73%
Expedia (EXPE)	2010-2012	506.19%
Domino's Pizza Inc Common Stock (DPZ)	2010-2012	451.67%
Ulta Beauty (ULTA)	2010-2012	416.69%
Lululemon Athletica (LULU)	2010-2012	393.88%
United Rentals (URI)	2010-2012	358.87%
Generac (GNRC)	2010-2012	251.61%
Tractor Supply (TSCO)	2010-2012	240%
Chipotle Mexican Grill (CMG)	2010-2012	231.99%
LyondellBasell Industries (LYB)	2010-2012	231.79%
Las Vegas Sands (LVS)	2010-2012	221.6%
Transdigm (TDG)	2010-2012	210.18%
Lennar (LEN)	2010-2012	209.36%
Booking (BKNG)	2010-2012	179.05%
Monster Beverage (MNST)	2010-2012	173.36%
Biogen (BIIB)	2010-2012	171.21%
Ross Stores (ROST)	2010-2012	161.35%
Sherwin-Williams (SHW)	2010-2012	160.4%
Estee Lauder Companies (EL)	2010-2012	153.83%
Gartner (IT)	2010-2012	152.58%
Apple (AAPL)	2010-2012	151.56%
Old Dominion Freight Line (ODFL)	2010-2012	151.24%
Dollar Tree (DLTR)	2010-2012	150.68%
PPG Industries (PPG)	2010-2012	147.25%
TJX Companies (TJX)	2010-2012	144.84%