The Oklahoma City Thunder have the lowest point differential by a team in a home game, with a -57 point differential against the Pacers on May 1, 2021.

Interpreted as:

biggest loss by a team in a home regular-season game

	TEAM	DIFF	DATE	TM		OPP	RESULT	MIN	PTS	REB	AST	STL	BLK	FGM	FGA	FG%	3PM	3PA	3P%	FTM	FTA	FT%	TS%	OREB	DREB	TOV	PF
1	Thunder	-57	5/1/2021	OKC	vs	IND	L 95-152	240	95	48	23	8	4	38	111	34.2	8	38	21.1	11	23	47.8	39.2	21	27	14	15
2	Trail Blazers	-56	4/9/2023	POR	vs	GSW	L 101-157	240	101	30	25	5	3	38	95	40.0	9	35	25.7	16	24	66.7	47.8	6	24	14	9
3	Bulls	-56	12/8/2018	CHI	vs	BOS	L 77-133	240	77	37	16	3	2	31	81	38.3	6	24	25.0	9	14	64.3	44.2	8	29	15	17
4	Rockets	-56	12/6/1986	HOU	vs	SEA	L 80-136	240	80	37	17	9	2	31	93	33.3	0	5	0.0	18	25	72.0	38.5	20	17	19	25
5	Wizards	-53	3/27/2025	WAS	vs	IND	L 109-162	240	109	31	19	9	2	38	85	44.7	11	30	36.7	22	26	84.6	56.5	12	19	15	15
6	Hornets	-53	12/16/2023	CHA	vs	PHI	L 82-135	240	82	36	15	3	4	33	91	36.3	7	35	20.0	9	11	81.8	42.8	8	28	11	14
7	Celtics	-52	1/31/2003	BOS	vs	DET	L 66-118	240	66	40	11	6	1	23	77	29.9	8	22	36.4	12	19	63.2	38.7	11	29	14	22
8	Clippers	-51	12/27/2020	LAC	vs	DAL	L 73-124	240	73	36	13	2	2	26	76	34.2	4	33	12.1	17	20	85.0	43.0	5	31	12	19
9	76ers	-51	12/7/2015	PHI	vs	SAS	L 68-119	240	68	31	14	3	1	26	75	34.7	4	24	16.7	12	21	57.1	40.4	6	25	13	25
10	Knicks	-50	1/24/2010	NYK	vs	DAL	L 78-128	240	78	46	14	4	2	29	86	33.7	4	25	16.0	16	21	76.2	40.9	22	24	16	15
11	76ers	-50	3/18/2007	PHI	vs	HOU	L 74-124	240	74	36	10	4	3	27	80	33.8	4	10	40.0	16	18	88.9	42.1	8	28	12	14
12	Pelicans	-49	4/11/2025	NOP	vs	MIA	L 104-153	240	104	42	27	6	2	38	95	40.0	14	37	37.8	14	20	70.0	50.1	12	30	13	16
13	Kings	-49	4/28/2021	SAC	vs	UTA	L 105-154	240	105	24	24	8	6	42	87	48.3	7	21	33.3	14	17	82.4	55.6	3	21	12	19
14	Rockets	-49	2/28/2021	HOU	vs	MEM	L 84-133	240	84	38	10	7	6	23	83	27.7	4	45	8.9	34	41	82.9	41.6	12	26	23	24
15	Nets	-49	11/17/1978	NJN	vs	WAS	L 94-143	240	94	36	22			39	94	41.5				16	18	88.9	46.1				19
16	76ers	-48	2/15/2022	PHI	vs	BOS	L 87-135	240	87	40	17	7	2	23	80	28.8	8	32	25.0	33	39	84.6	44.8	12	28	9	17
17	Suns	-48	2/7/2018	PHX	vs	SAS	L 81-129	240	81	44	15	8	4	33	97	34.0	3	32	9.4	12	18	66.7	38.6	11	33	11	23
18	Suns	-48	10/18/2017	PHX	vs	POR	L 76-124	240	76	33	10	9	8	28	89	31.5	7	27	25.9	13	18	72.2	39.2	10	23	16	22
19	Lakers	-48	3/6/2014	LAL	vs	LAC	L 94-142	240	94	33	26	9	2	34	86	39.5	8	30	26.7	18	26	69.2	48.2	4	29	22	16
20	Bucks	-48	2/20/1995	MIL	vs	ORL	L 104-152	240	104	46	25	7	2	41	102	40.2	6	15	40.0	16	26	61.5	45.8	21	25	17	19
21	76ers	-48	11/29/1972	PHI	vs	NYK	L 91-139	240	91	48	17			43	104	41.3				5	8	62.5	42.3				21
22	Warriors	-48	1/5/1969	SFW	vs	BOS	L 86-134	240	86	69	15			32	102	31.4				22	35	62.9	36.6				23
23	Pistons	-48	12/20/1968	DET	vs	NYK	L 87-135	240	87	52	13			33	89	37.1				21	31	67.7	42.4				23
24	Heat	-47	12/29/2020	MIA	vs	MIL	L 97-144	240	97	30	23	9	6	37	79	46.8	11	37	29.7	12	18	66.7	55.8	3	27	21	18
25	Bulls	-47	4/2/1999	CHI	vs	ORL	L 68-115	240	68	27	20	10	1	29	77	37.7	1	9	11.1	9	21	42.9	39.4	10	17	16	22